Angiosarcoma of skull in a pregnant woman: case report and review of the literature

Abstract

Angiosarcoma is a rare tumor of bone that uncommonly involves the skull. Primary neoplasms of the skull represent 2.6% of primary neoplasms of bone. We wish to report a case of angiosarcoma of he skull in an 18-year-old pregnant woman who presented with a rapidly growing left frontotemporal mass. Neuroimaging revealed a left frontotemporal mass with destruction of diploic space and both tables and with extension to the subgaleal and epidural spaces. The patient underwent surgery and the tumor was removed totally. Histological features of angiosarcoma were seen in the pathology study. She received adjuvant chemotherapy and radiation therapy. She has remained well during 6 years of follow-up with no evidence of recurrence. Angiosarcoma is a rare malignant bone tumor of vascular origin. Our case is the only female patient with skull angiosarcoma that has been reported so far.KeywOrds: Angiosarcoma, Skull, Neoplasm, Tumor ÖZAnjiosarkoma nadir görülen ve kafatasını da az sıklıkta tutan bir tümördür. Kafatası kaynaklı tümörler birincil kemik tümörleri içinde yaklaşık olarak % 2,6'lık bir yer tutar. Olgumuzda 18 yaşında hamile kadında sol frototemporal bölgeye yerleşmiş ve hızlı büyüme gösteren angiosarkoma sunulmaktadır. Görüntüleme çalışmalarında tümörün sol frontotemporal bölgede diplöe mesafesinde harabiyet yaptığı, her iki tabulayı da tuttuğu ve subgaleal ve epidural mesafelere doğru ilerlediği görüldü. Hasta ameliyat edildi ve tümör dokusunun tamamı çıkarıldı. Tümörün patolojik incelemesinde belirgin angisarkom özellikleri görüldü. Doku tanısı sonrası hastaya radyoterapi ve adjuvan kemoterapi uygulandı. Hastanın 6 yıllık izleminde rekürrensi olmadı. Anjiosarkoma nadir görülen, vasküler kökenli malin bir kemik tümörüdür. Vakamız, literatürde şu ana kadar sunulan bir kadında kafatası yerleşimli ilk anjiosarkom olgusudur.

Bone and soft tissue sarcomas during pregnancy: A narrative review of the literature

“…Two were located to the breast and one to the skull. No data are available for the other two patients [9] , [81] , [82] , [83] .…”

Subdural Hematoma Caused by Epithelioid Angiosarcoma Originating from the Skull

“…They are rare tumors accounting for less than 1 % of all sarcomas [9,10]. Primary skull angiosarcomas are particularly rare with less than 20 cases reported in the literature [12][13][14][15], which primarily explains why SDH caused by angiosarcomas is so rare. There seems to be a difference between SDH caused by angiosarcomas and that caused by other common cancers in the clinical presentation.…”