Angiotensin Converting Enzyme and Substance P Changes in Blister Fluid Following Afferent Nerve Stimulation in the Rat

Jackson, Bruce; White, David A.; Cubela, Rose; Helme, R. D.

doi:10.1111/j.1440-1681.1985.tb02322.x

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…Treatment with ACE inhibitors has been reported to restore these blunted responses. 31 -" The mechanism of this effect has not been established but may involve bradykinin. Bradykinin can stimulate the release of both vasodilating prostaglandins as well as endothelium-derived relaxing factor or nitric oxide from endothelial cells.…”

Section: Role Of Tissue Angiotensin Converting Enzyme In Cardiovasculmentioning

confidence: 99%

“…30 Inflammatory blister fluid also has a higher content of bradykinin and substance P in animals given ACE inhibitors. 31 There is a strong feeling but little direct evidence that some of the adverse effects of ACE inhibitors such as cough and angioneurotic edema may involve bradykinin. Whether bradykinin, a potent vasodilator, contributes to the acute or chronic hypotensive effect of ACE inhibitors is still controversial.…”

Section: Introductionmentioning

confidence: 99%

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Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling.

Johnston

1994

Hypertension

160

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A 52-year-old white man presented with a small full wall thickness anterior myocardial infarct. He L was given intravenous streptokinase, aspirin, and nitrates, and his course was uncomplicated.He had suffered mild essential hypertension for 10 years and had been treated over this period with moduretic (one tablet per day). His primary physician had excluded causes of secondary hypertension, and he had been told that his blood pressure control on the diuretic was satisfactory (documented at levels between 146 and 138 mm Hg systolic and 90 and 96 mm Hg diastolic). His serum cholesterol levels had been measured on several occasions, and the last reading was 6.8 mmol/dL (205 mg%).A chest radiograph performed in the hospital showed cardiomegaly, and his electrocardiogram showed high voltage over his anterior chest leads. An echocardiogram confirmed increased posterior and septal thicknesses, with normal fractional shortening. A radionuclide ventriculogram showed a left ventricular ejection fraction of 40%. Serum creatinine concentration was within normal limits, as were serum potassium and blood glucose levels.His blood pressure on presentation to the hospital with the myocardial infarction was 160/100 mm Hg and remained at this level for the first 24 hours. On the second day, 6.25 mg captopril was given and then 12.5 mg twice daily. His blood pressure fell to 150/95 mm Hg, and his captopril dose was increased to 25 mg twice daily.On discharge from the hospital, his blood pressure was 140/82 mm Hg. Six months later, on medical review, his blood pressure was 142/84 mm Hg, his cholesterol was 5.5 mg/dL, and his left ventricular hypertrophy had regressed.This man presents with a very common clinical and management problem: a middle-aged man with longstanding treated hypertension and left ventricular hypertrophy complicated by an acute myocardial infarct.Dr Johnston was an invited speaker at

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Section: Role Of Tissue Angiotensin Converting Enzyme In Cardiovasculmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling.

Johnston

1994

Hypertension

160

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“…The regulation of soluble ACE during inflammation is, thus, not different in these rats. A decrease in soluble ACE also occurs in the blister fluid in the rat blister model (59) or in the plasma of arthritis patients (34).…”

Section: Discussionmentioning

confidence: 99%

Exclusion of Angiotensin I-Converting Enzyme as a Candidate Gene Involved In Exudative Inflammatory Resistance in F344/N Rats

Jafarian-Tehrani

Listwak

Barrientos

et al. 2000

Mol Med

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“…Patients were included regardless of the indication for angiotensin converting enzyme inhibitor therapy. Eleven cases who had an adverse reaction to captopril and were ___ Repnnr requesfs 10 also treated with enalapril were documented. These are grouped according to their adverse effects.…”

Section: Patientsmentioning

confidence: 99%

Lack of Cross Sensitivity Between Captopril and Enalapril

Jackson

Maher²,

Matthews³

et al. 1988

Australian and New Zealand Journal of Medicine

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Oral inhibitors of angiotensin converting enzyme (ACE) now have an established place in the treatment of hypertension and heart failure. Captopril, the first of these agents, was initially used in high doses and was associated with adverse effects including proteinuria, skin rash and taste disturbance. We report 11 patients who developed side effects during captopril therapy (proteinuria two, rash four, taste disturbance four and taste disturbance with rash one) who were subsequently treated with enalapril, a second generation angiotensin converting enzyme inhibitor. Proteinuria did not recur in either patient, skin rash resolved in all five cases and taste disturbance resolved in four of five during enalapril therapy. We conclude that the side effects of proteinuria, skin rash and taste disturbance are consequences of captopril idiosyncrasy rather than inhibition of the angiotensin converting enzyme. The reported incidence of these side effects with the current recommended dosage of captopril is low.

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Angiotensin Converting Enzyme and Substance P Changes in Blister Fluid Following Afferent Nerve Stimulation in the Rat

Cited by 4 publications

References 9 publications

Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling.

Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling.

Exclusion of Angiotensin I-Converting Enzyme as a Candidate Gene Involved In Exudative Inflammatory Resistance in F344/N Rats

Lack of Cross Sensitivity Between Captopril and Enalapril

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