Angiotensin-Converting Enzyme DD Polymorphism is Associated with Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease

Ceyhan, Köksal; Kadı, Hasan; Çelik, Ataç; Burucu, Turgay; Koç, Fatih; Söğüt, Erkan; Sahin, Şevki; Özer, Orhan

doi:10.2310/jim.0b013e31823908e2

Cited by 9 publications

(8 citation statements)

References 67 publications

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“…3 Table 6 summarizes previous studies that are related to ACE genotype associations. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] In the present study, we investigated the possible association of ACE I/D polymorphisms with the development of GDM among selected individuals from the Asian Indian population. The study was carried out between two groups (GDM cases and non-GDM subjects) and showed significant differences with respect to age, weight and PPBG.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus

Khan

Jahan

Hasan

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Introduction: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first recognized during pregnancy. Insertion/deletion (I/D) polymorphism of a 287 bp Alu repetitive sequence in intron 16 of the angiotensin-converting enzyme (ACE) gene has been widely investigated in Asian Indian populations with different ethnic origins. The present study examined possible association between I/D polymorphism of the ACE gene and GDM in Asian Indian pregnant women. Methods: A total of 200 pregnant women (100 GDM and 100 non-GDM) were recruited in this study and I/D polymorphism of a 287 bp Alu1 element inside intron 16 of the ACE gene was examined by polymerase chain reaction (PCR)-based gel electrophoresis. Result: The distribution of the variants like II, ID, and DD genotypes of ACE gene showed differences between normal GDM versus non-GDM subjects, and the frequency of the ID+ DD Vs II genotype was significant (p=0.0002) in the GDM group. Conclusion: ACE gene polymorphism was associated with GDM in Asian Indian pregnant women.

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Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus

Khan

Jahan

Hasan

et al. 2013

J Renin Angiotensin Aldosterone Syst

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“…Recently, it has been shown that angiotensin-converting enzyme DD polymorphism is associated with poor CCC. 13 About one third to one fourth of patients with coronary artery disease, especially the ones involving multiple arteries, may not be candidates for revascularization procedures. In these patients, an alternative way of supplying blood to the distal part of the occluded artery is CCC.…”

mentioning

confidence: 99%

The Relationship between High-Density Lipoprotein Cholesterol and Coronary Collateral Circulation in Patients with Coronary Artery Disease

Kadı

Özyurt

Ceyhan

et al. 2012

Journal of Investigative Medicine

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“…; Ceyhan et al. ). In this regard, while the WKY is typically used as the normotensive control for the SHR, genetic differences exist between these two inbred strains.…”

Section: Discussionmentioning

confidence: 98%

“…It is important to note that flow-mediated remodeling is mediated by multiple, complex mechanisms and the specific mechanisms responsible for impairment of flowmediated remodeling may differ depending upon specific risk factors present (Kinnaird et al 2008) and genetic background (Hochberg et al 2002;Sheridan et al 2007;Ceyhan et al 2012). In this regard, while the WKY is typically used as the normotensive control for the SHR, genetic differences exist between these two inbred strains.…”

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confidence: 99%

Molecular basis for impaired collateral artery growth in the spontaneously hypertensive rat: insight from microarray analysis

et al. 2013

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Analysis of global gene expression in mesenteric control and collateral arteries was used to investigate potential molecules, pathways, and mechanisms responsible for impaired collateral growth in the Spontaneously Hypertensive Rat (SHR). A fundamental difference was observed in overall gene expression pattern in SHR versus Wistar Kyoto (WKY) collaterals; only 6% of genes altered in collaterals were similar between rat strains. Ingenuity® Pathway Analysis (IPA) identified major differences between WKY and SHR in networks and biological functions related to cell growth and proliferation and gene expression. In SHR control arteries, several mechano-sensitive and redox-dependent transcription regulators were downregulated including JUN (−5.2×, P = 0.02), EGR1 (−4.1×, P = 0.01), and NFĸB1 (−1.95×, P = 0.04). Predicted binding sites for NFĸB and AP-1 were present in genes altered in WKY but not SHR collaterals. Immunostaining showed increased NFĸB nuclear translocation in collateral arteries of WKY and apocynin-treated SHR, but not in untreated SHR. siRNA for the p65 subunit suppressed collateral growth in WKY, confirming a functional role of NFkB. Canonical pathways identified by IPA in WKY but not SHR included nitric oxide and renin–angiotensin system signaling. The angiotensin type 1 receptor (AGTR1) exhibited upregulation in WKY collaterals, but downregulation in SHR; pharmacological blockade of AGTR1 with losartan prevented collateral luminal expansion in WKY. Together, these results suggest that collateral growth impairment results from an abnormality in a fundamental regulatory mechanism that occurs at a level between signal transduction and gene transcription and implicate redox-dependent modulation of mechano-sensitive transcription factors such as NFĸB as a potential mechanism.

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Angiotensin-Converting Enzyme DD Polymorphism is Associated with Poor Coronary Collateral Circulation in Patients with Coronary Artery Disease

Abstract: This study showed that ACE DD polymorphism is associated with poor CCC. Poor collateral circulation in patients carrying the D allele may be associated with endothelial dysfunction and elevated blood ACE levels in these patients.

Cited by 9 publications

References 67 publications

Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus

Angiotensin-converting enzyme gene insertion/deletion polymorphism studies in Asian Indian pregnant women biochemically identifies gestational diabetes mellitus

The Relationship between High-Density Lipoprotein Cholesterol and Coronary Collateral Circulation in Patients with Coronary Artery Disease

Molecular basis for impaired collateral artery growth in the spontaneously hypertensive rat: insight from microarray analysis

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