Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey

Nk, Turhan; Su, I Ya-Min; Ac, Hamamcioglu; Üstündağ, Yücel; Dursun, Ahmet; Köktürk, Fürüzan

doi:10.4238/2015.december.16.8

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…Several studies, reported that, the angiotensin receptor blockers or ACE inhibitors have been shown to ameliorate the liver fibrosis progression, Jonsson et al [24] and Zhu et al [6] suggesting that ACE gene expression may be an important marker for liver fibrosis severity. Turhan et al [25] , reported that, the frequency of I/D genotypes were higher than the D/D and I/I genotypes both mild to moderate and advanced fibrosis, these findings were partially agreed with our findings. Additionally, Güçlü et al [8] , reported that, no significant relation between D/D, D/I and I/I genotype frequency and liver fibrosis.…”

Section: Discussionsupporting

confidence: 93%

The Relationship of Angiotensin I-Converting Enzyme Genotype to Liver Fibrogenesis in Non-Alcoholic Steatohepatitis

Diab¹,

Attia²,

ELSHORMILISY³

et al. 2019

The Medical Journal of Cairo University

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Background: Multiple genetic and environmental factors may lead to fibrogenesis in patients with Non-alcoholic fatty liver (NAFL). Many studies investigated the relation of angiotensin I-converting enzyme (ACE) genotyping to liver fibrosis in chronic liver disease; and the results are contradictory. Aim of Study:In the current study, ACE genotype was assessed in NAFLD patients to show its possible association with development liver fibrosis. Subjects and Methods:The study included 162 patients of NAFLD disease, 49 (30.25%) patients with mild fibrosis, 65 (40.12%) with moderate fibrosis and 48 (29.63%) with severe fibrosis in addition to 138 volunteers was enrolled as a healthy controls. All patients and controls were investigated to serum glucose and fasting insulin level and HOMA-IR was calculated. Liver function tests, both serum ACE and transforming growth factor-beta (TGF-b) were done. ACE genotyping [insertion/deletion (I/D)] was done by PCR.Results: Fasting glucose and insulin, HOMA-IR, AST, ALT and GGT were significantly higher in NAFLD patients than healthy controls. The homozygous frequency I/I and D/D or D/I of ACE were not significantly different between NAFLD patients and controls. The D/D genotype was associated significantly with the severity of liver fibrosis, D/I polymorphism with moderate fibrosis and I/I genotype with mild fibrosis. The higher D allele frequency was associated with severe fibrosis, while I allele was frequent in mild fibrosis. The HOMA-IR, ALT, serum ACE and TGF-b were increased significantly in the patients carrying D/D homozygous gene more than those carrying homozygous I/I or D/I polymorphism. The serum ACE and TGF-b were significantly higher in NAFLD patients compared to control and the most higher levels was reported in cases with severe liver fibrosis than moderate and mild liver fibrosis.

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Section: Discussionsupporting

confidence: 93%

The Relationship of Angiotensin I-Converting Enzyme Genotype to Liver Fibrogenesis in Non-Alcoholic Steatohepatitis

Diab¹,

Attia²,

ELSHORMILISY³

et al. 2019

The Medical Journal of Cairo University

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“…When these two studies are considered together, the most critical problem is that the number of researched patients and control group is very small (Purnak et al 17 included 50 chronic hepatitis B patients vs. 20 healthy controls, and Efe et al 18 had 73 patients with autoimmune hepatitis vs. 32 healthy controls); some patients in the study group had signs of cirrhosis. Also, these results are not confirmed in a relatively wide range of studies performed by Turhan et al 23 as well as our study. A similar discrepancy that has been noticed in some of the drug studies refers to blockage of RAS.…”

Section: Figurecontrasting

confidence: 98%

“…22 Measuring serum ACE levels is one of them, showing promising results in early studies, although some paradoxical outcomes have also been reported recently. [16][17][18]23 The issue of non--invasive methods has increasingly attracted many researchers, and frequently new studies on the topic are added to the literature.…”

Section: Resultsmentioning

confidence: 99%

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Is serum angiotensin converting enzyme level a useful non-invasive marker for liver fibrosis in patients with chronic hepatitis C?

Akar

2018

Rev. Assoc. Med. Bras.

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“…The patients were classified into two groups according to the stage of liver fibrosis identified by liver biopsy and FibroScan according to Ishak's scoring system [22]:…”

Section: Groupsmentioning

confidence: 99%

Body mass index (BMI) and alpha-fetoprotein (AFP) level correlate with the severity of HCV-induced fibrosis in a cohort of Egyptian patients with chronic HCV

Mohamed¹,

Hemeda²,

Aziz³

et al. 2020

Futur J Pharm Sci

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Background Viral hepatitis is the seventh leading cause of mortality globally, and half of this mortality is attributed to hepatitis C virus (HCV). Egypt has the highest HCV prevalence worldwide, with an estimated 14.7% of the population being HCV-positive. HCV infection is the primary cause of liver fibrosis, cirrhosis, and hepatocellular carcinoma. Liver fibrosis varies in severity during chronic HCV infection, and 10–20% of chronic hepatitis C (CHC) patients with severe fibrosis develop cirrhosis. The goal of this work was to assess the clinico-demographic predictors of severity of HCV-induced fibrosis in a cohort of Egyptian patients. Results A cohort of Egyptian patients with chronic HCV genotype 4a infection showed significant association between severe fibrosis stages and obesity, represented by a higher body mass index (BMI), low albumin level, high alpha-fetoprotein (AFP) level, low thyroid-stimulating hormone (TSH) level, and high alkaline phosphatase (ALP) level. Multivariate analysis delineated BMI, TSH, and ALP as independent significant variables that could predict the risk of fibrosis severity in HCV infections. Conclusion This study argues in favor of using the biomarker profile of CHC patients infected with HCV genotype 4a to identify patients at higher risk of developing severe fibrosis, which is a necessary first step towards precision medicine via patient stratification.

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Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey

Cited by 4 publications

References 35 publications

The Relationship of Angiotensin I-Converting Enzyme Genotype to Liver Fibrogenesis in Non-Alcoholic Steatohepatitis

The Relationship of Angiotensin I-Converting Enzyme Genotype to Liver Fibrogenesis in Non-Alcoholic Steatohepatitis

Is serum angiotensin converting enzyme level a useful non-invasive marker for liver fibrosis in patients with chronic hepatitis C?

Body mass index (BMI) and alpha-fetoprotein (AFP) level correlate with the severity of HCV-induced fibrosis in a cohort of Egyptian patients with chronic HCV

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