Angiotensin-converting enzyme I/D polymorphism is associated with pneumonia risk: A meta-analysis

Nie, Wei; Zang, Yuan‐Sheng; Chen, Jiquan; Liu, Tao; Lin, Xiao; Xiu, Qingyu

doi:10.1177/1470320313507622

Cited by 17 publications

(14 citation statements)

References 28 publications

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“…A recently published meta-analysis concerning the same topic suggested a significant association with pneumonia risk. 34 In this work, the authors combined 1431 cases and 3600 controls, of which 977 samples should be excluded (the reason was described in study inclusion and characteristics). In addition, the data included were not all in accord with those provided in original articles.…”

Section: Discussionmentioning

confidence: 99%

Genetic Association Between CD143 rs4340 Polymorphism and Pneumonia risk

et al. 2015

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Abstractrs4340 polymorphism at intron 16 of the angiotensin-converting enzyme (CD143) gene was reported to repress cough reflex by reducing bradykinin and substance P levels, thus increasing the likelihood to develop pneumonia. There have been different reports regarding the correlation of CD143 rs4340 genotypes with pneumonia risk, which prompted us to perform a meta-analysis to determine the elusive association.We combined multiple keywords to identify the studies addressing the association between CD143 rs4340 genotypes and pneumonia risk covered in the EMBASE, Google Scholar, PubMed, and CNKI databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the risk of pneumonia. The fixed-effects model (FEM) was used.A total of 10 studies were analyzed in this quantitative analysis. We found a strong association between rs4340 single nucleotide polymorphism (SNP) and pneumonia risk using the recessive model (FEM: OR 1.33, 95% CI 1.13–1.57). A significantly increased risk was also indicated under the recessive model in Asian populations (FEM: OR 1.57, 95% CI 1.19–2.07), community-acquired pneumonia (CAP) (FEM: OR 1.31, 95% CI 1.08–1.60), and nosocomial pneumonia (NP) (FEM: OR 1.52, 95% CI 1.06–2.19).Our meta-analysis demonstrates that CD143 rs4340 polymorphism may represent a risk factor for pneumonia.

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Section: Discussionmentioning

confidence: 99%

Genetic Association Between CD143 rs4340 Polymorphism and Pneumonia risk

et al. 2015

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“…An upregulation of Ang II/AT1R-mediated signaling has been identified in various pathologic conditions, including pulmonary diseases [18,28]. Indeed, the activation of the ACE/Ang II/AT1R cascade is associated with increased pneumonia risk and worse prognosis [29]. In experimental lipopolysaccharide (LPS)-induced lung fibrosis, Ang II levels were slightly elevated in the plasma and even more increased in the bronchoalveolar lavage fluid.…”

Section: Ras and Pulmonary Diseasesmentioning

confidence: 99%

Renin–Angiotensin System: An Important Player in the Pathogenesis of Acute Respiratory Distress Syndrome

Hrenak

Šimko

2020

IJMS

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Acute respiratory distress syndrome (ARDS) is characterized by massive inflammation, increased vascular permeability and pulmonary edema. Mortality due to ARDS remains very high and even in the case of survival, acute lung injury can lead to pulmonary fibrosis. The renin–angiotensin system (RAS) plays a significant role in these processes. The activities of RAS molecules are subject to dynamic changes in response to an injury. Initially, increased levels of angiotensin (Ang) II and des-Arg9-bradykinin (DABK), are necessary for an effective defense. Later, augmented angiotensin converting enzyme (ACE) 2 activity supposedly helps to attenuate inflammation. Appropriate ACE2 activity might be decisive in preventing immune-induced damage and ensuring tissue repair. ACE2 has been identified as a common target for different pathogens. Some Coronaviruses, including SARS-CoV-2, also use ACE2 to infiltrate the cells. A number of questions remain unresolved. The importance of ACE2 shedding, associated with the release of soluble ACE2 and ADAM17-mediated activation of tumor necrosis factor-α (TNF-α)-signaling is unclear. The roles of other non-classical RAS-associated molecules, e.g., alamandine, Ang A or Ang 1–9, also deserve attention. In addition, the impact of established RAS-inhibiting drugs on the pulmonary RAS is to be elucidated. The unfavorable prognosis of ARDS and the lack of effective treatment urge the search for novel therapeutic strategies. In the context of the ongoing SARS-CoV-2 pandemic and considering the involvement of humoral disbalance in the pathogenesis of ARDS, targeting the renin–angiotensin system and reducing the pathogen’s cell entry could be a promising therapeutic strategy in the struggle against COVID-19.

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“…Систематический обзор и метаанализ, составленный Wei Nie и соавт. [20], посвящен сравнительной оценке двух режимов АБТ: β-лактамные антибиотики в качестве монотерапии в сопоставлении с двухкомпонентной терапией макролидами и β-лактамными антибиотиками. В базе данных находится 2946 публикаций на эту тему, однако критериям включения в обзор соответствовало только 16 статьей.…”

Section: терапевтический архив 3 2016unclassified

Pneumonia: The urgent problem of 21st century medicine

Chuchalin

2016

Ter. arkh.

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The paper analyzes the systematic reviews and meta-analyses on the strategic issues of pneumonia, which have been published in the past 3 years. It discusses the prevalence and mortality rates of acquired pneumonia, hospital-acquired (nosocomial) pneumonia, healthcare-associated pneumonia, ventilator-associated pneumonia, and Mycoplasma pneumonia, and the specific features of their etiology, diagnosis, and treatment. A large number of investigations emphasize the relevance of this problem in current clinical practice.

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Angiotensin-converting enzyme I/D polymorphism is associated with pneumonia risk: A meta-analysis

Abstract: Our meta-analysis confirmed that ACE I/D polymorphism was associated with pneumonia risk. However, ACE I/D polymorphism was not associated with pneumonia mortality.

Cited by 17 publications

References 28 publications

Genetic Association Between CD143 rs4340 Polymorphism and Pneumonia risk

Genetic Association Between CD143 rs4340 Polymorphism and Pneumonia risk

Renin–Angiotensin System: An Important Player in the Pathogenesis of Acute Respiratory Distress Syndrome

Pneumonia: The urgent problem of 21st century medicine

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