Angiotensin‐converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case‐control study

Abouzeid, Heba; Alkholy, Usama M.; Abdou, M.; Morsy, Saeed; Abdelrahman, Hind M.; Sherif, Ashraf M.; Abdalmonem, Nermin; Kotb, M.; Allah, Mayy A.N.; Morshedy, Salah Al; Elashkar, Shaimaa S. A.; Noah, Maha A.; Hegab, Mohamed S.; Akeel, Nagwa E.; Hashem, Mustafa; Gawish, Heba H; Fattah, Lobna Abdel

doi:10.1002/ppul.23886

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…In an interesting case-control study, it was reported that the angiotensin converting enzyme polymorphism rs4340 was associated with increased risk for CAP in Egyptian children. 48…”

Section: Respiratory Infectionsmentioning

confidence: 99%

“…Genetic factors may affect susceptibility to CAP. In an interesting case‐control study, it was reported that the angiotensin converting enzyme polymorphism rs4340 was associated with increased risk for CAP in Egyptian children . Erlichman et al in Israel reported a retrospective analysis of 144 hospitalized patients over a 10‐year period, with CAP complicated by necrotizing pneumonia, empyema, or parapneumonic effusion .…”

Section: Introductionmentioning

confidence: 99%

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Pediatric Pulmonology year in review 2017: Part 3

Ren

Muston

Yılmaz

et al. 2018

Pediatric Pulmonology

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Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection.Word count: 71 3

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“…In an interesting case-control study, it was reported that the angiotensin converting enzyme polymorphism rs4340 was associated with increased risk for CAP in Egyptian children. 48…”

Section: Respiratory Infectionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pediatric Pulmonology year in review 2017: Part 3

Ren

Muston

Yılmaz

et al. 2018

Pediatric Pulmonology

View full text Add to dashboard Cite

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Association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents

Boraey,

Bebars,

Wahba

et al. 2024

Pediatr Res

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Background Given the sparse data on the renin-angiotensin system (RAS) and its biological effector molecules ACE1 and ACE2 in pediatric COVID-19 cases, we investigated whether the ACE1 insertion/deletion (I/D) polymorphism could be a genetic marker for susceptibility to COVID-19 in Egyptian children and adolescents. Methods This was a case-control study included four hundred sixty patients diagnosed with COVID-19, and 460 well-matched healthy control children and adolescents. The I/D polymorphism (rs1799752) in the ACE1 gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA. Results The ACE1 D/D genotype and Deletion allele were significantly more represented in patients with COVID-19 compared to the control group (55% vs. 28%; OR = 2.4; [95% CI: 1.46–3.95]; for the DD genotype; P = 0.002) and (68% vs. 52.5%; OR: 1.93; [95% CI: 1.49–2.5] for the D allele; P = 0.032). The presence of ACE1 D/D genotype was an independent risk factor for severe COVID-19 among studied patients (adjusted OR: 2.6; [95% CI: 1.6–9.7]; P < 0.001. Conclusions The ACE1 insertion/deletion polymorphism may confer susceptibility to SARS-CoV-2 infection in Egyptian children and adolescents. Impact Recent studies suggested a crucial role of renin-angiotensin system and its biological effector molecules ACE1 and ACE2 in the pathogenesis and progression of COVID-19. To our knowledge, ours is the first study to investigate the association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Caucasian children and adolescents. The presence of the ACE1 D/D genotype or ACE1 Deletion allele may confer susceptibility to SARS-CoV-2 infection and being associated with higher ACE serum levels; may constitute independent risk factors for severe COVID-19. The ACE1 I/D genotyping help design further clinical trials reconsidering RAS-pathway antagonists to achieve more efficient targeted therapies.

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