Angiotensin I-Converting Enzyme Insertion/Deletion Polymorphism and Cardiac Mortality and Morbidity After Coronary Artery Bypass Graft Surgery

Renin–angiotensin system and haemostasis gene polymorphisms and outcome after coronary artery bypass graft surgery

“…These gene-to-environment interactions may help to explain some discrepancies in the literature. While some studies [4,5] demonstrated certain variants of reninangiotensin system genes can be risk factors for cardiovascular diseases, other studies [21,22] found that the same variants were more common in the elderly and even among centenarians. As shown in Figs.…”

“…The haptoglobin 2-2 genotype has been shown to be associated with a shortened graft survival time in patients who had recurrent coronary artery bypass grafting [23] and a polymorphism of the interleukin-6 gene has been reported to be associated with the length of stay in the intensive care unit after coronary revascularization [24]. Recently, associations between gene polymorphisms of the renin-angiotensin system and certain outcome variables after coronary artery bypass graft operation have been described [4,25]. For example, a chymase gene variant has been reported to be associated with the degree of arteriosclerosis in venous coronary artery bypass grafts [25] and a gene polymorphism of the angiotensin I-converting enzyme gene has been found to be associated with the mid-term outcome after coronary artery bypass graft surgery [4].…”

“…Clinical, laboratory and angiographic data were obtained from medical records. Operation details have been described elsewhere [4].…”

“…Besides these variables, genetic factors may contribute to the outcome after coronary artery bypass graft surgery. Thus, we have recently shown that the angiotensin I-converting enzyme DD genotype is associated with an increased mid-term mortality and cardiac morbidity after coronary artery bypass graft surgery [4].…”

Outcome after coronary artery bypass graft surgery, coronary angioplasty and stenting

“…Diagnostic coronary catheterizations are also performed in three further clinics that transfer patients to the Heart Center Karlsburg in case of coronary findings requiring invasive treatment. Patient characteristics have been previously reported [11,12]. In brief, inclusion criteria were CAD requiring invasive treatment and main residency in Western Pomerania.…”