Angiotensin II activates different calcium signaling pathways in adipocytes

Dolgacheva, Lyudmila P.; Turovskaya, M. V.; Дынник, В. В.; Зинченко, В. П.; Гончаров, Н. В.; Davletov, Bazbek; Turovsky, Egor A.

doi:10.1016/j.abb.2016.02.001

Cited by 18 publications

(17 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Signaling through the AT 1 Rs/AT 2 Rs, ANG II activates different calcium signaling pathways in adipocytes, an area of investigation that still remains poorly characterized (237). This study first demonstrated that ANG II initiates periodic Ca 2ϩ oscillations and transient responses by activating AT 1 Rs/AT 2 Rs and involving branched signaling cascades.…”

Section: B Roles Of Ang II Receptor Signaling In Adipose Tissuementioning

confidence: 82%

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

Forrester

Booz

Sigmund

et al. 2018

Physiological Reviews

821

780

View full text Add to dashboard Cite

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology and pathophysiology. However, many of the signaling mechanisms have been unclear. The angiotensin II (ANG II) type 1 receptor (ATR) is believed to mediate most functions of ANG II in the system. ATR utilizes various signal transduction cascades causing hypertension, cardiovascular remodeling, and end organ damage. Moreover, functional cross-talk between ATR signaling pathways and other signaling pathways have been recognized. Accumulating evidence reveals the complexity of ANG II signal transduction in pathophysiology of the vasculature, heart, kidney, and brain, as well as several pathophysiological features, including inflammation, metabolic dysfunction, and aging. In this review, we provide a comprehensive update of the ANG II receptor signaling events and their functional significances for potential translation into therapeutic strategies. ATR remains central to the system in mediating physiological and pathophysiological functions of ANG II, and participation of specific signaling pathways becomes much clearer. There are still certain limitations and many controversies, and several noteworthy new concepts require further support. However, it is expected that rigorous translational research of the ANG II signaling pathways including those in large animals and humans will contribute to establishing effective new therapies against various diseases.

show abstract

Section: B Roles Of Ang II Receptor Signaling In Adipose Tissuementioning

confidence: 82%

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

Forrester

Booz

Sigmund

et al. 2018

Physiological Reviews

821

780

View full text Add to dashboard Cite

show abstract

“…; Dolgacheva et al . ). To present the time course of nitric oxide production rate, we calculated discrete derivative [d( F / F 0 )/d t ] traces.…”

Section: Methodsmentioning

confidence: 97%

Acetylcholine released by endothelial cells facilitates flow‐mediated dilatation

Wilson

Lee

McCarron

2016

The Journal of Physiology

106

124

View full text Add to dashboard Cite

Key points The endothelium plays a pivotal role in the vascular response to chemical and mechanical stimuli.The endothelium is exquisitely sensitive to ACh, although the physiological significance of ACh‐induced activation of the endothelium is unknown.In the present study, we investigated the mechanisms of flow‐mediated endothelial calcium signalling.Our data establish that flow‐mediated endothelial calcium responses arise from the autocrine action of non‐neuronal ACh released by the endothelium. AbstractCirculating blood generates frictional forces (shear stress) on the walls of blood vessels. These frictional forces critically regulate vascular function. The endothelium senses these frictional forces and, in response, releases various vasodilators that relax smooth muscle cells in a process termed flow‐mediated dilatation. Although some elements of the signalling mechanisms have been identified, precisely how flow is sensed and transduced to cause the release of relaxing factors is poorly understood. By imaging signalling in large areas of the endothelium of intact arteries, we show that the endothelium responds to flow by releasing ACh. Once liberated, ACh acts to trigger calcium release from the internal store in endothelial cells, nitric oxide production and artery relaxation. Flow‐activated release of ACh from the endothelium is non‐vesicular and occurs via organic cation transporters. ACh is generated following mitochondrial production of acetylCoA. Thus, we show ACh is an autocrine signalling molecule released from endothelial cells, and identify a new role for the classical neurotransmitter in endothelial mechanotransduction.

show abstract

“…In contrast, mature adipocytes demonstrate regular calcium oscillations in response to AngII addition. These oscillations are induced by AT 1 R‐dependent activation of PLC and IP 3 production and are supported by phosphoinositide 3‐kinase (PI3K)/Akt‐dependent potentiation of ryanodine receptors . After receptor stimulation, the βγ subunits of G q protein dissociate and activate a number of signalling cascade characteristic for tyrosine kinases, including PLC gamma/Ca 2+ , PI3K/Akt and extracellular signal‐regulated kinase 1/2 (ERK1/2) mitogen‐activated protein (MAP) kinases .…”

Section: Ras In the Regulation Of White Adipose Tissue Functioningmentioning

confidence: 99%

Angiotensin receptor subtypes regulate adipose tissue renewal and remodelling

et al. 2020

View full text Add to dashboard Cite

Obesity is often associated with high systemic and local renin–angiotensin system (RAS) activity in adipose tissue. Adipose‐derived mesenchymal stem/stromal cells (ADSCs), responsible for adipose tissue growth upon high‐fat diet, express multiple angiotensin II receptor isoforms, including angiotensin II type 1 receptor (AT1R), angiotensin II type 2 receptor (AT2R), Mas and Mas‐related G protein‐coupled receptor D. Although AT1R is expressed on most ADSCs, other angiotensin receptors are co‐expressed on a small subpopulation of the cells, a phenomenon that results in a complex response pattern. Following AT1R activation, the effects are transient due to rapid receptor internalisation. This short‐lived effect can be prevented by heteromerisation with AT2R, a particularly important strategy for the regulation of ADSC differentiation and secretory activity. Heteromeric AT2R might be especially important for the generation of thermogenic beige adipocytes. This review summarises current data regarding the regulation of adipose tissue renewal and particularly ADSC adipogenic differentiation and secretory activity by RAS, with an emphasis on AT2R and its effects. We reveal a new scheme that implicates AT2R into the regulation of ADSC hormonal sensitivity.

show abstract

Angiotensin II activates different calcium signaling pathways in adipocytes

Cited by 18 publications

References 55 publications

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

Acetylcholine released by endothelial cells facilitates flow‐mediated dilatation

Angiotensin receptor subtypes regulate adipose tissue renewal and remodelling

Contact Info

Product

Resources

About