2012
DOI: 10.1038/ki.2011.306
|View full text |Cite
|
Sign up to set email alerts
|

Angiotensin II-dependent persistent podocyte loss from destabilized glomeruli causes progression of end stage kidney disease

Abstract: Podocyte depletion is a major mechanism driving glomerulosclerosis. Progression is the process by which progressive glomerulosclerosis leads to End Stage Kidney Disease (ESKD). We therefore tested the hypothesis that progression to ESKD can be caused by persistent podocyte loss using the human diphtheria toxin transgenic rat model. After initial podocyte injury causing >30% loss of podocytes glomeruli became destabilized, resulting in continuous podocyte loss over time until global podocyte depletion (ESKD) oc… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

9
177
0

Year Published

2012
2012
2024
2024

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 132 publications
(186 citation statements)
references
References 58 publications
9
177
0
Order By: Relevance
“…These models have the disadvantage that it is not always possible to establish the exact dose to produce a specific degree of renal insufficiency, in addition to the possible occurrence of side effects that may compromise the experimental model. On the other hand, the surgical procedures, characterized by the removal of portions of the renal tissue, have been widely used because they have a high survival rate and a low cost, do not have side effects and can be used to produce progressive levels of renal failure, as shown in this study [11][12][13][14][15][16] .…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…These models have the disadvantage that it is not always possible to establish the exact dose to produce a specific degree of renal insufficiency, in addition to the possible occurrence of side effects that may compromise the experimental model. On the other hand, the surgical procedures, characterized by the removal of portions of the renal tissue, have been widely used because they have a high survival rate and a low cost, do not have side effects and can be used to produce progressive levels of renal failure, as shown in this study [11][12][13][14][15][16] .…”
Section: Discussionmentioning
confidence: 99%
“…The discrepancy of these results could be explained by the use of differente species and/or lineages of animals and due to differences in surgical protocols of renal tissue removal [11][12][13][14] .…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Recently, Fukuda et al . [99] provided a mechanistic explanation for the ā€œhyperfiltration hypothesisā€ demonstrating that local activation of the renin-angiotensin system within the glomerular tuft leads to an increase in angiotensin II concentration within the glomerulus. The first short-term effect of angiotensin is adaptive alterations in the podocyte cytoskeleton and increases in filtration pressures.…”
Section: A Lifeboat For the Glomerulus: The Renal Progenitor Cellsmentioning
confidence: 99%