Angiotensin II induces human placental lactogen and pregnancy-specific β1-glycoprotein secretion via an angiotensin AT1 receptor

Kalenga, M K; Gasparo, Marc de; Thomas, Karl; Hertogh, R. De

doi:10.1016/0922-4106(94)90193-7

Cited by 23 publications

(14 citation statements)

References 10 publications

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“…The specific localisation to the apical microvillous membrane of the syncytiotrophoblast is consistent with the inhibition of the system A amino acid transporter (Shibata et al 2006), and the stimulation of placental lactogen and 17b-estradiol synthesis by exogenous Ang II (Kalenga et al 1994(Kalenga et al , 1995 This study has demonstrated that high concentrations of Ang II significantly increase villous cytotrophoblast proliferation (assessed by BrdU incorporation and Ki67 immunostaining), but do not affect apoptosis (measured by CK-18 cleavage and TUNEL). Blockade of AGTR1 and AGTR2 together reduces cytotrophoblast proliferation index.…”

Section: Discussionsupporting

confidence: 77%

Differential expression of angiotensin II type 1 and type 2 receptors at the maternal–fetal interface: potential roles in early placental development

Tower

Liu²,

Charlesworth

et al. 2010

Reproduction

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Angiotensin II (Ang II) is locally generated in the placenta and regulates syncytial transport, vascular contractility and trophoblast invasion. It acts through two receptor subtypes, AGTR1 and AGTR2 (AT1 and AT2), which typically mediate antagonising actions. The objectives of this study are to characterise the cellular distribution of AGTR1 and AGTR2 at the maternal-fetal interface and explore the effects on cytotrophoblast turnover. Low levels of AGTR2 mRNA were detected in first trimester placental homogenates using real-time PCR. Immunohistochemistry using polyclonal antibodies against AGTR1 and AGTR2 detected the receptors in first trimester placenta, decidua basalis and villous tip outgrowths in culture. Serial staining with cytokeratin-7 was used to identify extravillous trophoblasts (EVTs). AGTR1 was found in the syncytiotrophoblast microvillous membrane, in a subpopulation of villous cytotrophoblasts, and in Hofbauer cells. AGTR1 was strongly upregulated in cytotrophoblasts in cell columns and villous tip outgrowths, but was absent in interstitial and endovascular EVTs within the decidua. AGTR2 immunostaining was present in Hofbauer cells and villous cytotrophoblasts, but was absent from syncytiotrophoblast. Faint staining was detected in cell column cytotrophoblasts and villous outgrowths, but not in EVTs within the decidua. Both receptors were detected in placental homogenates by western blotting. Ang II significantly increased proliferation of cytotrophoblasts in both villous explants and villous tip outgrowths, but did not affect apoptosis. Blockade of AGTR1 and AGTR2 together abrogated this effect. This study shows specific expression patterns for AGTR1 and AGTR2 in distinct trophoblast populations at the maternal-fetal interface and suggests that Ang II plays a role in placental development and generation of EVTs.Reproduction (2010) 140 931-942

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Section: Discussionsupporting

confidence: 77%

Differential expression of angiotensin II type 1 and type 2 receptors at the maternal–fetal interface: potential roles in early placental development

Tower

Liu²,

Charlesworth

et al. 2010

Reproduction

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“…As shown in Figure 8, we found no binding of 125 I-[Sar 1 -Ile 5 -Ile 8 ]-Ang II to the bovine placental lactogen-producing binucleate and trinucleate cells situated in the trophoblast cell layer and maternal uterine epithelium [27]. This finding suggests that Ang II does not regulate the secretion of placental lactogen in the bovine placenta, in contrast to the findings in the humans [12].…”

Section: Discussioncontrasting

confidence: 55%

“…Recent in vitro studies using human trophoblast cells have demonstrated that Ang II stimulated human placental lactogen and specific ␤1-glycoprotein secretion through the AT 1 receptor [12]. As shown in Figure 8, we found no binding of 125 I-[Sar 1 -Ile 5 -Ile 8 ]-Ang II to the bovine placental lactogen-producing binucleate and trinucleate cells situated in the trophoblast cell layer and maternal uterine epithelium [27].…”

Section: Discussionmentioning

confidence: 50%

“…In humans and in ewes, Ang II is one of the factors that regulate the blood flow in the uteroplacental unit, and it thereby indirectly influences the fetal volume homeostasis and oxygenation [8][9][10]. Ang II also stimulates placental lactogen, pregnancy-specific ␤ 1 -glycoprotein, and estradiol secretion in human trophoblast cells via AT 1 receptors [11][12][13]. The physiological effects of the AT 2 receptor are presently much less characterized.…”

Section: Introductionmentioning

confidence: 99%

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Autoradiographic Localization and Characterization of Angiotensin II Receptors in the Bovine Placenta and Fetal Membranes1

Schauser¹,

Nielsen²,

Winther³

et al. 1998

Biology of Reproduction

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Autoradiography and angiotensin (Ang) II receptor binding studies showed that all parts of the bovine placenta and fetal membranes contained high densities of Ang II receptors throughout gestation. The receptors were predominantly subtype 2 (AT2) receptors in the fetal and subtype 1 (AT1) receptors in the maternal compartment. In the allantoamnionic membrane, Ang II receptors were evenly distributed in the mesenchymal tissue, with the highest expression around the few arteries. In the intercotyledonary and cotyledonary allantochorionic membrane, AT2 receptors as well as the less-expressed AT1 receptors were located on mesenchymal cells, especially adjacent to the allantoic endoderm, trophoblast cell layer, and arteries. In the mesenchymal tissue of the placentome, Ang II receptors were mostly expressed at the main branches of the fetal villi of the cotyledons. In the maternal part of the placentome, mainly AT1 receptors but also low densities of AT2 receptors and non-AT1/non-AT2 Ang II binding sites were found close to the stalk and at the main branches of the maternal crypts. Autoradiography revealed no changes in the pattern of distribution of the Ang II receptors throughout gestation. It is suggested that Ang II has an effect on regulatory as well as growth processes in these tissues.

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“…Ang II induces HPL secretion by placental explants and isolated trophoblastic cells via an angiotensin AT1 receptor [19]. Thus, the correlation observed between reduced placental AT1 expression and reduced Ang II-evoked HPL secretion by extracorporeally perfused placental lobules in IUGR seems to be reasonable.…”

Section: Discussionmentioning

confidence: 80%

Angiotensin II (Ang II) evoked secretion of the human placental lactogen (HPL) in intrauterine growth retardation: Examination of the relationship with Ang II receptor type 1 (AT1) expression

Szukiewicz

Maślińska

Gujski

et al. 2008

International Immunopharmacology

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Angiotensin II induces human placental lactogen and pregnancy-specific β1-glycoprotein secretion via an angiotensin AT1 receptor

Cited by 23 publications

References 10 publications

Differential expression of angiotensin II type 1 and type 2 receptors at the maternal–fetal interface: potential roles in early placental development

Differential expression of angiotensin II type 1 and type 2 receptors at the maternal–fetal interface: potential roles in early placental development

Autoradiographic Localization and Characterization of Angiotensin II Receptors in the Bovine Placenta and Fetal Membranes1

Angiotensin II (Ang II) evoked secretion of the human placental lactogen (HPL) in intrauterine growth retardation: Examination of the relationship with Ang II receptor type 1 (AT1) expression

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