Angiotensin II type 1 receptor blocker telmisartan suppresses superoxide production and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice

Bone Marrow Transplantation Reveals That Recipient AT1a Receptors Are Required to Initiate Angiotensin II–Induced Atherosclerosis and Aneurysms

“…29 Recent studies demonstrate that administration of the AT1 receptor antagonist, telmisartan, to ApoEϪ/Ϫ mice at a dose that did not lower blood pressure suppressed atherosclerotic lesion formation. 30 Collectively, these results suggest that reductions in blood pressure in AT1a receptor-deficient mice were not the primary mechanism for ablation of AngII-induced atherosclerosis and/or AAA formation in AT1a receptordeficient mice. Both AngII-induced atherosclerosis and AAAs are characterized by complex changes of many cell types that are both resident and infiltrates of the arterial wall.…”

Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy

“…Recent experimental studies have shown that telmisartan attenuates oxidative stress by downregulating NAD(P)H oxidase, a major superoxide-producing enzyme. 22,23 By contrast, the effect of telmisartan on a superoxide-scavenging enzyme, SOD, has not been clarified. Therefore, we next tested whether telmisartan treatment ameliorates the reduced SOD antioxidant defense capacity in the DN stage of microalbuminuria.…”

Effect of Telmisartan on Nitric Oxide–Asymmetrical Dimethylarginine System

“…13 Besides its effect on blood pressure, telmisartan reduces atherosclerosis in apolipoprotein Edeficient mice via decreased oxidative stress. 14 Moreover, telmisartan improves endothelial function in human 15 and animal 16,17 models by influencing the NO system. Recent studies have shown that telmisartan, in comparison to other ARBs when tested at concentrations that may be achievable in plasma after administration of doses used for the treatment of essential hypertension, activates also peroxisome proliferator activated receptor (PPAR) ␥, 18 a nuclear hormone receptor and a well-known target of antidiabetic drugs.…”