Abstract:The objective was to determine the effect of treatment with an ACE inhibitor, enalapril (EN), on cardiac oxidative stress. Male Kyoto and SHR (15 wks) were treated for 10 weeks with EN or control (gavage, 10 mg/kg, n = 7/group). After treatment, blood pressure (BP) and heart rate were recorded from an arterial catheter (Windaq, 2KHz). Rats were euthanized with collection of heart with measurement of cardiac index (ventricle weight/body weight; mg/g), chemiluminescence (CL) and carbonyl assay. Akt and MAPK (Erk… Show more
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