Our patient is a 61-year-old, male, heavy smoker, and diagnosed with diabetes mellitus (DM) who sought medical intervention due to complaints of painful lesions on the left and right corners of the mouth. The patient lost a lot of teeth, only two remained intact and has never used dentures. We present a case of angular cheilitis in an elderly patient with DM and a decrease of vertical dimensions. Clinical management includes anamnesis, clinical examination, treatment and elimination of predisposing factors through integrated multidisciplinary treatment.