Angular gyrus connectivity at alpha and beta oscillations is reduced during tonic pain – Differential effect of eye state

Alhajri, Najah; Boudreau, Shellie; Graven‐Nielsen, Thomas

doi:10.1016/j.nicl.2021.102907

Cited by 10 publications

(16 citation statements)

References 84 publications

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“…Therefore, this study investigated how the DMN connectivity at alpha (but not beta) contributes to peak pain intensity. Additionally, our previous work (Alhajri et al, 2022b) along with other findings (Klimesch et al, 2006; Nir et al, 2012) have also shown that lower alpha (8–10 Hz) may be more involved in pain perception than upper alpha (11–13 Hz) oscillations. Therefore, the contribution of pain‐free DMN connectivity to pain intensity was examined at lower alpha (8–10 Hz).…”

Section: Methodssupporting

confidence: 61%

“…Using a discrete multiple source method (Scherg et al, 2019), EEG data were transformed in BESA to source space, and pre‐defined resting‐state source montages for the DMN were used focusing on four regions: mPFC, PCC, right and left angular gyrus (rAG and lAG) (Alhajri et al, 2022b). The locations of the DMN areas were determined by Montreal Neurological Institution based on the DMN system described by Power et al (Power et al, 2011).…”

Section: Methodsmentioning

confidence: 99%

“…Fifty-two healthy right-handed volunteers (26 women, age 26.2 ± 4.6 years, mean [M] ± standard deviation [SD]) were recruited online and through flyers posted at Aalborg University and participated in two studies where prospective data have already been published (Alhajri et al, 2022a(Alhajri et al, , 2022b, and the present report represents a secondary analysis based on baseline data. The volunteers who were involved in the initial study did not participate in the subsequent study.…”

Section: Participantsmentioning

confidence: 99%

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Pain‐free default mode network connectivity contributes to tonic experimental pain intensity beyond the role of negative mood and other pain‐related factors

Alhajri

Boudreau

Mouraux

et al. 2023

European Journal of Pain

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BackgroundAlterations in the default mode network (DMN) connectivity across pain stages suggest a possible DMN involvement in the transition to persistent pain.AimThis study examined whether pain‐free DMN connectivity at lower alpha oscillations (8‐10 Hz) accounts for a unique variation in experimental peak pain intensity beyond the contribution of factors known to influence pain intensity.MethodsPain‐free DMN connectivity was measured with electroencephalography prior to 1 h of capsaicin‐evoked pain using a topical capsaicin patch on the right forearm. Pain intensity was assessed on a (0–10) numerical rating scale and the association between peak pain intensity and baseline measurements was examined using hierarchical multiple regression in 52 healthy volunteers (26 women). The baseline measurements consisted of catastrophizing (helplessness, rumination, magnification), vigilance, depression, negative and positive affect, sex, age, sleep, fatigue, thermal and mechanical pain thresholds and DMN connectivity (medial prefrontal cortex [mPFC]‐posterior cingulate cortex [PCC], mPFC‐right angular gyrus [rAG], mPFC‐left Angular gyrus [lAG], rAG‐mPFC and rAG‐PCC).ResultsPain‐free DMN connectivity increased the explained variance in peak pain intensity beyond the contribution of other factors (ΔR2 = 0.10, p = 0.003), with the final model explaining 66% of the variation (R2 = 0.66, ANOVA: p < 0.001). In this model, negative affect (β = 0.51, p < 0.001), helplessness (β = 0.49, p = 0.007), pain‐free mPFC‐lAG connectivity (β = 0.36, p = 0.003) and depression (β = −0.39, p = 0.009) correlated significantly with peak pain intensity. Interestingly, negative affect and depression, albeit both being negative mood indices, showed opposing relationships with peak pain intensity.ConclusionsThis work suggests that pain‐free mPFC‐lAG connectivity (at lower alpha) may contribute to individual variations in pain‐related vulnerability.SignificanceThese findings could potentially lead the way for investigations in which DMN connectivity is used in identifying individuals more likely to develop chronic pain.

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Section: Methodssupporting

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

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Pain‐free default mode network connectivity contributes to tonic experimental pain intensity beyond the role of negative mood and other pain‐related factors

Alhajri

Boudreau

Mouraux

et al. 2023

European Journal of Pain

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“…Another interesting aspect of the AG in the process of sensemaking is the ability to integrate multimodal information. One can draw parallels with a similar AG role in the subjective nature of pain perception (Alhajri et al, 2021), as pain processing also depends on the integration of complex sensory, cognitive and emotional aspects in a personalized and contextdependent manner.…”

Section: Section 6: Outstanding Questions For Future Researchmentioning

confidence: 91%

Multiple functions of the angular gyrus at high temporal resolution

Seghier

2022

Brain Struct Funct

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Here, the functions of the angular gyrus (AG) are evaluated in the light of current evidence from transcranial magnetic/electric stimulation (TMS/TES) and EEG/MEG studies. 65 TMS/TES and 52 EEG/MEG studies were examined in this review. TMS/TES literature points to a causal role in semantic processing, word and number processing, attention and visual search, self-guided movement, memory, and self-processing.EEG/MEG studies reported AG effects at latencies varying between 32 ms and 800 ms in a wide range of domains, with a high probability to detect an effect at 300-350 ms poststimulus onset. A three-phase unifying model revolving around the process of sensemaking is then suggested: (1) early AG involvement in defining the current context, within the first 200 ms, with a bias toward the right hemisphere; (2) attention reorientation and retrieval of relevant information within 200-500 ms; and (3) cross-modal integration at late latencies with a bias toward the left hemisphere. This sensemaking process can favour accuracy (e.g. for word and number processing) or plausibility (e.g. for comprehension and social cognition). Such functions of the AG depend on the status of other connected regions. The much-debated semantic role is also discussed: (1) there is a strong TMS/TES evidence for a causal semantic role, (2) current EEG/MEG evidence is however weak, but (3) the existing arguments against a semantic role for the AG are not strong. Some outstanding questions for future research are proposed. This review recognizes that cracking the role(s) of the AG in cognition is possible only when its exact contributions within the default mode network are teased apart.

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“…As with Study I and II, the sensory-motor interaction between electrical stimuli and MVF-induced illusory movements investigated in Study III was related to the underlying neurophysiological oscillatory mechanism at the alpha frequency (alpha ERD/ERS), an EEG rhythm acknowledged for its role in motor and sensorynociceptive processes 89,120,123 as well as for its functional meaning within the core structures of the triple network (ECN, DMN, and SN) [239][240][241] . In Study III, the alpha ERD in the frontoparietal cortical areas reflects the activation of the executive efferent motor outputs enacted to interfere with the concomitant afferent sensory inputs.…”

Section: Role Of Attentional Triple Network In Pain Modulationmentioning

confidence: 87%

Spatial distribution and temporal evolution of EEG alpha rhythms related to sensory-motor tasks during Mirror Visual Feedback illusion

Rizzo¹

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Angular gyrus connectivity at alpha and beta oscillations is reduced during tonic pain – Differential effect of eye state

Cited by 10 publications

References 84 publications

Pain‐free default mode network connectivity contributes to tonic experimental pain intensity beyond the role of negative mood and other pain‐related factors

Pain‐free default mode network connectivity contributes to tonic experimental pain intensity beyond the role of negative mood and other pain‐related factors

Multiple functions of the angular gyrus at high temporal resolution

Spatial distribution and temporal evolution of EEG alpha rhythms related to sensory-motor tasks during Mirror Visual Feedback illusion

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