Anhedonia in depression: biological mechanisms and computational models

Cooper, Jessica A.; Arulpragasam, Amanda R.; Treadway, Michael T.

doi:10.1016/j.cobeha.2018.01.024

Cited by 133 publications

(101 citation statements)

References 65 publications

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“…Moreover, as suggested by preclinical research, stimulation at the left ear exerted stronger effects on vigor when food rewards were at stake. We conclude that taVNS may provide a promising brain stimulation technique to improve motivational syndromes characterized by a lack of vigor to pursue rewards such as apathy (Bonnelle et al, 2015;Husain & Roiser, 2018;Muhammed et al, 2016;Pessiglione, Vinckier, Bouret, Daunizeau, & Le Bouc, 2017) or anhedonia (Cooper, Arulpragasam, & Treadway, 2018;Treadway, Peterman, Zald, & Park, 2015;Treadway & Zald, 2011). These findings also add to the growing literature demonstrating the crucial role of peripheral interoceptive signals in tuning instrumental behavior according to metabolic needs.…”

Section: Discussionsupporting

confidence: 61%

Vagus nerve stimulation increases vigor to work for rewards

Neuser

Teckentrup

Kuehnel

et al. 2019

Preprint

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Interoceptive feedback transmitted via the vagus nerve plays a vital role in motivation by tuning actions according to physiological needs. Whereas vagus nerve stimulation (VNS) reinforces actions and enhances dopamine transmission in animals, motivational effects elicited by VNS in humans are still largely elusive. Here, we applied non-invasive transcutaneous auricular VNS (taVNS) on the left or the right ear using a randomized cross-over design (vs. sham). During stimulation, 81 healthy participants had to exert effort to earn food or monetary rewards. We reasoned that taVNS enhances motivation and tested whether it does so by increasing prospective benefits (i.e., vigor) or reducing costs of action (i.e., maintenance) compared to sham stimulation. In line with preclinical studies, taVNS generally enhanced invigoration of effort (p = .004, Bayes factor, BF10 = 7.34), whereas stimulation on the left side primarily facilitated vigor for food rewards (left taVNS: Stimulation × Reward Type, p = .003, BF10 = 11.80). In contrast, taVNS did not affect effort maintenance (ps ≥ .09, BF10 < 0.52). Critically, during taVNS, vigor declined less steeply with decreases in wanting (∆b = -.046, p = .031) indicating a boost in the drive to work for rewards. Collectively, our results suggest that taVNS enhances reward-seeking by boosting vigor, not effort maintenance and that the side of the stimulation affects generalization beyond food reward. We conclude that taVNS may enhance the pursuit of prospective rewards which may pave new avenues for treatment of motivational deficiencies. taVNS increases vigor Neuser et al.3

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Section: Discussionsupporting

confidence: 61%

Vagus nerve stimulation increases vigor to work for rewards

Neuser

Teckentrup

Kuehnel

et al. 2019

Preprint

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“…Apathy is described as diminished emotional responsiveness, lack of initiation, interest or participation in daily activities, as reviewed here from this current special issue [30]. Clearly this sounds similar to anhedonia in depression, as reviewed in this current special issue [31] and symptoms of amotivation across diagnostic boundaries [32,33]. Importantly, apathy can occur without the clinical emotional distress that is seen in depression [34] yet Levy and Dubois claim apathy in depression possibly arises from anhedonia which they describe as an insensitivity to pleasure [35].…”

Section: The Need For Anhedonia Specific Scales For Adolescentsmentioning

confidence: 90%

“…Furthermore advances have been made in understanding human behaviour during effort and motivational tasks by using computational modelling this has been reviewed recently here [58]** and in this current special issue [31,59]. This is a promising new approach able to disentangle processes that underpin the trade-off between effort and reward [58].…”

Section: Anhedonia and Physical Effort In Adolescent Depressionmentioning

confidence: 99%

Linking anhedonia symptoms with behavioural and neural reward responses in adolescent depression

McCabe

2018

Current Opinion in Behavioral Sciences

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Adolescence is a period of change that crucially increases vulnerability to depression. Studies report blunted neural responses to reward that relate to positive affect and depression symptoms in adolescents. However how these results relate to the symptom of anhedonia in adolescents is not entirely clear. Anhedonia is not a unitary construct, but is described as having different processes (e.g. wanting vs. liking) each underpinned by different neurobiological pathways. Current studies report inconsistencies in findings when trying to relate reward processing at the behavioural and neural level with symptoms. One reason for this is the lack of specificity of clinical, behavioural and neural tasks for measuring reward in depression. Links between the experience of anhedonia in adolescent depression and the behavioural and neural measures of reward could be improved with more detailed questionnaires, more detailed measurements of the components of reward for e.g. decreased motivation/effort and more ecologically valid tasks relevant to adolescents, in the MRI scanner. Prevalence of adolescent depression Major Depressive Disorder (MDD) is characterized by persistent sadness, loss of interest or pleasure, feelings of worthlessness or guilt, sleep disturbances, poor concentration and suicidal thoughts. The World Health Organisation reports that depression is the predominant cause of illness and disability for both boys and girls aged 10 to 19 years [1]. As adolescence is a time of physical, social and psychological change, it is easy to see how this could contribute to mental health problems. Early-onset adolescent depression has a detrimental impact on normal development and leads to poorer outcomes in adulthood. Harrington et al., found that 60% of adults with adolescent onset depression experienced one or more episodes of MDD in adulthood compared to 27% in the control group [2]. Additionally a significant increased risk of later anxiety disorder, nicotine dependence,

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“…Anhedonia, defined as the diminished ability to experience pleasure or enjoy previously pleasurable activities, is a diagnostic feature of depression and shown to be a predictor of antidepressant nonresponse [73,74]. Validated self-reported measures for anhedonia used in clinical research include the Snaith-Hamilton Pleasure Scale (SHAPS), the Fawcett-Clark Pleasure Capacity Scale (FCPS), the Revised Chapman Physical Anhedonia Scale (CPAS) and the Chapman Social Anhedonia Scale (CSAS) [75].…”

Section: Depression In Psoriatic Arthritis Is Multi-dimensional With mentioning

confidence: 99%

Depression in Psoriatic Arthritis: Dimensional Aspects and Link with Systemic Inflammation

Mathew

Chandran

2020

Rheumatol Ther

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Studying comorbidities in patients with psoriatic arthritis (PsA) provides a better understanding of the extended burden of the disease. Depression and anxiety are well recognized but understudied comorbidities in patients with PsA. The prevalence of depression is significantly higher in this patient population than in the general population, with far reaching consequences in terms of long-term quality of life. Over the past few years there has been an increasing interest in the link between inflammation and depression, with several novel studies being conducted. Recent evidence suggests a significant improvement of depression in PsA patients treated with biologic disease-modifying anti-rheumatic drugs (bDMARDs) as compared to conventional DMARDs. Depression in PsA is multidimensional, with recognized phenotypes, including cognitive disorder, alexithymia and anhedonia. The paucity of standardized, validated tools to screen these dimensional phenotypes remains an unmet need. Prevalence studies on depression in patients with PsA, mostly based on patient-reported outcomes, are only able to highlight the tip of the iceberg. A comprehensive, multidisciplinary approach addressing the subdomains of depression is imperative for a better understanding of depression in PsA patients, as well as to find a way forward for improving their quality of life. In this scoping review, we explore existing evidence on the burden of depression in PsA patients, the link between inflammation and depression in these patients and the screening tools used to evaluate the subdomains of depression.

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Anhedonia in depression: biological mechanisms and computational models

Cited by 133 publications

References 65 publications

Vagus nerve stimulation increases vigor to work for rewards

Vagus nerve stimulation increases vigor to work for rewards

Linking anhedonia symptoms with behavioural and neural reward responses in adolescent depression

Depression in Psoriatic Arthritis: Dimensional Aspects and Link with Systemic Inflammation

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