Anhydrous microwave synthesis as efficient method for obtaining model advanced glycation end-products
Agnieszka Bronowicka-Szydełko,
Katarzyna Madziarska,
Aleksandra Kuzan
et al.
Abstract:IntroductionAdvanced glycation end-products (AGEs) are capable of stimulating oxidative stress and inflammation. This study investigates the synthesis of medium crosslinked AGEs (the most optimal form of AGEs because of soluble in water, used in many assays as markers) and their biochemical properties.MethodsOne of model protein–myoglobin from horse heart muscle (MB) and a chosen respective glycation factor – D-melibiose (mel), acrolein (ACR), D-glucose (glc), 4-hydroksynonenal (4HNE), trans-2-nonenal (T2N), m… Show more
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