Anicteric Hepatitis in Korea

Chung, Whan-Kook

doi:10.1001/archinte.1964.00280100034007

Cited by 16 publications

(2 citation statements)

References 6 publications

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“…Among them, the dissociation of CH50 titers be tween serum and plasma of more than 10 U/ml (group A), 5-10 U/ml (group B) and less than 5 U/ml (group C) were ob served in 10, 6 and 23 cases, respectively. In group A, 6 patients were liver cirrhosis including 1 patient accompanied with hepa toma, 2 were chronic hepatitis and 1 was nonspecific reactive hepatitis [2], Group B included 3 patients with liver cirrhosis, 1 with chronic hepatitis, 1 with nonspecific reactive hepatitis and 1 patient with system ic lupus erythematosus (SLE). The CH50 ti ters of all plasma samples in group A and B were higher than those of the corresponding serum samples.…”

Section: Resultsmentioning

confidence: 99%

Nonparticipation of C1q in the Decrease of Complement Activity in the Cold in Sera of Patients with Chronic Liver Diseases

Yoshida

Morito

Onizawa

et al. 1980

Int Arch Allergy Immunol

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Serum and plasma samples taken simultaneously from 560 patients with various diseases were examined for hemolytic complement activity (CH50) after incubation at 4 °C for 20 h. Serum CH50 titers less than 20 U/ml were observed in 39 cases and among them, a difference between serum and plasma CH50 of more than 5 U/ml were observed in 16 cases. Diagnosis of most of them were chronic liver diseases. To analyze the dissociation of CH50 titers between serum and plasma, sequential estimations of CH50 were performed on serum and plasma samples which showed the dissocation incubated at 4 and 37 °C. Marked decrease in CH50 titers was obtained in sera but not in plasma incubated at 4 °C. In such sera, however, no significant decrease of protein amount and agglutinating activity of C1q was observed. The result could indicate that C1q would not participate in the decrease of serum hemolytic activity in the cold, suggesting an activation of complement other than the classical pathway.

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Section: Resultsmentioning

confidence: 99%

Nonparticipation of C1q in the Decrease of Complement Activity in the Cold in Sera of Patients with Chronic Liver Diseases

Yoshida

Morito

Onizawa

et al. 1980

Int Arch Allergy Immunol

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“…In Dr. Alfred M. Prince most of these, transaminase levels remained abnormal over a 3-month follow-up period [1]. Histologic examination revealed chronic active hepatitis in 18 of the 32 subjects which progressed to cirrhosis in 4 of these [2], The immunofluorescence studies revealed nu clear and cytoplasmic antigen(s) in groups of liver cells in 9 cases [3], As the antigens did not stain with convalescent serum from cases thought to represent hepatitis A, and were stained with serum from convalescent cases of what was then called 'serum hepa titis', we postulated that antigens specific for a serum hepatitis virus had been identified. This interpretation was confirmed many years later when the availability of tests for the hepatitis B surface antigen (HBsAg) in serum made it possible to confirm that the cases with antigen demonstrable by immu nofluorescence in liver were indeed chronic carriers of HBsAg and that the antiserum used in these studies indeed contained anti body to HBsAg (anti-HBs) and antibody to the core antigen (anti-HBc) [4],…”

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confidence: 99%