2016
DOI: 10.1016/j.pt.2016.04.012
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Animal African Trypanosomiasis: Time to Increase Focus on Clinically Relevant Parasite and Host Species

Abstract: 16 Animal African trypanosomiasis (AAT), caused by Trypanosoma congolense and 17Trypanosoma vivax, remains one of the most important livestock diseases in sub-18 Saharan Africa, particularly affecting cattle. Despite this, our detailed knowledge 19 largely stems from the human pathogen T. brucei and mouse experimental 20 models. In the post-genomic era the genotypic and phenotypic differences 21 between the AAT-relevant species of parasite or host and their 'model organism' 22 counterparts are increasingly app… Show more

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Cited by 133 publications
(110 citation statements)
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“…Ultimately, the disease caused by T. vivax has a different clinical presentation with high pathogenicity [44], which might cause higher morbidity and mortality rates alongside T. evansi , which on some occasions is also known to be highly pathogenic in camels. It is worth mentioning that T. vivax infection is also transmitted mechanically, as occurs in the case of T. evansi , by several Tabanids and a range of biting flies [45, 46]. This makes the transmission and the spread of infection possible in a wide range of camel populations in Sudan.…”
Section: Discussionmentioning
confidence: 99%
“…Ultimately, the disease caused by T. vivax has a different clinical presentation with high pathogenicity [44], which might cause higher morbidity and mortality rates alongside T. evansi , which on some occasions is also known to be highly pathogenic in camels. It is worth mentioning that T. vivax infection is also transmitted mechanically, as occurs in the case of T. evansi , by several Tabanids and a range of biting flies [45, 46]. This makes the transmission and the spread of infection possible in a wide range of camel populations in Sudan.…”
Section: Discussionmentioning
confidence: 99%
“…Other trypanosome species infect both domestic and wild animals, causing animal African trypanosomiasis. The infection of livestock has a major impact on the African economy, limiting the production of milk and meat and the development of agriculture in areas otherwise amenable to animal husbandry 2 .…”
Section: Introductionmentioning
confidence: 99%
“…T. brucei causes a fatal disease, African trypanosomiasis, in human and livestock [13]. The disease is prevalent in sub-Saharan Africa as it is the habitat of the tsetse fly, the insect vector of this parasite.…”
Section: Introductionmentioning
confidence: 99%