Animal Model-Based Studies to Evaluate the Lipid-Based Drug Delivery Nanocarriers for Cancer Treatment

R, Jino Affrald; Narayan, Shoba

doi:10.1007/978-981-19-1282-5_52-1

Handbook of Animal Models and Its Uses in Cancer Research 2022

DOI: 10.1007/978-981-19-1282-5_52-1

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Animal Model-Based Studies to Evaluate the Lipid-Based Drug Delivery Nanocarriers for Cancer Treatment

Jino Affrald R¹,

Shoba Narayan²

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2024

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Cited by 1 publication

References 92 publications

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Advancements in immunotherapy for colorectal cancer treatment: a comprehensive review of strategies, challenges, and future prospective

Kaviyarasan,

Das,

Deka

et al. 2024

Int J Colorectal Dis

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Purpose Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Metastatic colorectal cancer (mCRC) continues to present significant challenges, particularly in patients with proficient mismatch repair/microsatellite stable (pMMR/MSS) tumors. This narrative review aims to provide recent developments in immunotherapy for CRC treatment, focusing on its efficacy and challenges. Methods This review discussed the various immunotherapeutic strategies for CRC treatment, including immune checkpoint inhibitors (ICIs) targeting PD-1 and PD-L1, combination therapies involving ICIs with other modalities, chimeric antigen receptor T-cell (CAR-T) cell therapy, and cancer vaccines. The role of the tumor microenvironment and immune evasion mechanisms was also explored to understand their impact on the effectiveness of these therapies. Results This review provides a comprehensive update of recent advancements in immunotherapy for CRC, highlighting the potential of various immunotherapeutic approaches, including immune checkpoint inhibitors, combination therapies, CAR-T therapy, and vaccination strategies. The results of checkpoint inhibitors, particularly in patients with MSI-H/dMMR tumors, which have significant improvements in survival rates have been observed. Furthermore, this review also addresses the challenges faced in treating pMMR/MSS CRC, which remains resistant to immunotherapy. Conclusion Immunotherapy plays a significant role in the treatment of CRC, particularly in patients with MSI-H/dMMR tumors. However, many challenges remain, especially in treating pMMR/MSS CRC. This review discussed the need for further research into combination therapies, biomarker development, CAR-T cell therapy, and a deeper understanding of immune evasion mechanisms for CRC treatment.

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Advancements in immunotherapy for colorectal cancer treatment: a comprehensive review of strategies, challenges, and future prospective

Kaviyarasan,

Das,

Deka

et al. 2024

Int J Colorectal Dis

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show abstract

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Animal Model-Based Studies to Evaluate the Lipid-Based Drug Delivery Nanocarriers for Cancer Treatment

Cited by 1 publication

References 92 publications

Advancements in immunotherapy for colorectal cancer treatment: a comprehensive review of strategies, challenges, and future prospective

Advancements in immunotherapy for colorectal cancer treatment: a comprehensive review of strategies, challenges, and future prospective

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