Animal models of bone metastasis

Rosol, Thomas J.; Tannehill-Gregg, Sarah H.; LeRoy, Bruce E.; Mandl, Stefanie; Contag, Christopher H.

doi:10.1002/cncr.11150

Cited by 192 publications

(76 citation statements)

References 51 publications

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“…The role of retroviruses in the pathogenesis of human disease, however, is uncertain although proviral DNA, similar to MMTV, has been detected in a high percentage of human carcinomas [20]. Another major difference between human and spontaneous mouse mammary carcinoma is that approximately 50% of all human breast cancers are estrogen receptor positive whereas the vast majority of adenocarcinomas in mice rapidly loose their estrogen responsiveness [18,21]. Consequently, murine models of spontaneous mammary carcinoma do not precisely recapitulate steroid receptor signalling during neoplastic transformation [22].…”

Section: Spontaneous Mammary Carcinomamentioning

confidence: 99%

“…Overexpression of genes involved in mammary gland development is associated with mammary tumourigenesis and TGFa expression is upregulated in approximately 30-70% of breast cancers [21]. Several groups have established transgenic mice bearing TGFa under the control of MMTV-LTR, WAP or MT promoters [68][69][70][71].…”

Section: Transforming Growth Factor-alpha (Tgfa) Modelsmentioning

confidence: 99%

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From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies

Ottewell

Coleman

Holen

2005

Breast Cancer Res Treat

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Numerous mouse models of mammary cancer have been developed that mimic selective aspects of human disease. The use of these models has enabled preclinical chemotherapeutic, chemoprevention, and genetic therapy studies in vivo, the testing of gene delivery systems, and the identification of tumour and metastasis suppressor and inducer genes. This review has discussed the most abundantly used murine models of mammary cancer including: spontaneous tumours, chemically induced tumours, orthotopic and syngeneic tumour transplantation, injected tumours, and genetically engineered mice with a predisposition to neoplasia. Each model has been discussed with regards to its merits and limitations for investigating the genetic and phenotypic alterations involved in the human disease as well as its potential usefulness for the development of new treatment strategies. To date no single mouse model is available with the ability to replicate the entire disease process, however, existing models continue to provide invaluable insights into breast cancer induction and progression that would be impossible to obtain using in vitro models alone.

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Section: Spontaneous Mammary Carcinomamentioning

confidence: 99%

Section: Transforming Growth Factor-alpha (Tgfa) Modelsmentioning

confidence: 99%

From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies

Ottewell

Coleman

Holen

2005

Breast Cancer Res Treat

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“…However, in vivo models of spontaneous bone metastasis that arise in rodents or small mammals are uncommon [26]. Spontaneous development of mammary carcinomas can occur in mice and rats but most do not metastasize and metastasis to bone is very rare [27]. Therefore, the reliable and reproducible establishment of spinal metastases in experimental animal models requires either systemic or local inoculation of cancer cells.…”

Section: Establishment Of the Spinal Metastasismentioning

confidence: 99%

In vivo animal models of spinal metastasis

Cossigny

Quan

2011

Cancer Metastasis Rev

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The vertebral column is the commonest site for skeletal metastases, with breast, prostate and lung cancers being the most common primary sources. The spine has structural and neural-protective properties thus involvement by metastatic cancer often causes bony instability and fracture, intractable pain and neurological deficit. In vivo animal models which resemble the human condition are essential in order to improve understanding of the pathophysiology behind the spread of metastatic cancer to the spine and its subsequent local growth and invasion, to enable in-depth analysis of the interaction between host and tumour cells and the molecular processes behind local cancer invasion and barriers to invasion as well as to allow assessment of novel treatment modalities for spinal metastases. This review summarizes the current status of the animal models specifically used for the study of spinal metastasis, their relevance, advantages and limitations, and important considerations for the development of future in vivo animal models.

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“…Tibial injection of cancer cells [92] Genetically engineered mouse models [93] Intracardiac injection of cancer cells [94] models of bone metastasis, considering the roles of vascular transport and bone marrow endothelial cells in cancer cell transport and homing [103]. Several strategies have been developed to promote vascularization of engineered tissue following implantation, including biomaterial and scaffold modification, use of growth factors, and the use of co-culture systems [104].…”

Section: Bone Metastatic Diseasementioning

confidence: 99%

Human Bone Xenografts: from Preclinical Testing for Regenerative Medicine to Modeling of Diseases

Chong

Bao

et al. 2016

Curr Mol Bio Rep

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Xenografting involves the transplantation of human tissue or cells into animal models and is an important tool for regenerative medicine research. Implantation of engineered human bone tissues into animal models, for example, is performed in preclinical evaluations of product safety and efficacy. With the advent of improved experimental methodologies, these models are further being exploited to interrogate molecular mechanisms and physiological interactions in vivo. In parallel to these developments, patient-derived xenograft murine models of cancer are increasingly being studied for various applications in cancer research and therapy; it follows that xenograft models in tissue engineering may be adapted for such approaches. In this review, we first discuss the development of human bone xenograft models to recapitulate physiological states in regenerative medicine. Subsequently, we discuss the use of these techniques for applications in modeling pathological states in skeletal oncology, namely, hematopoietic malignancies, bone metastatic disease, and primary bone malignancy.

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Animal models of bone metastasis

Cited by 192 publications

References 51 publications

From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies

From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies

In vivo animal models of spinal metastasis

Human Bone Xenografts: from Preclinical Testing for Regenerative Medicine to Modeling of Diseases

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