Animal Models to Study Emerging Technologies Against SARS-CoV-2

Mullick, Jhinuk Basu; Simmons, Chelsey S.; Gaire, Janak

doi:10.1007/s12195-020-00638-9

Cited by 10 publications

(12 citation statements)

References 62 publications

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“…Mullick et al (Mullick et al 2020) emphasized the unique features of SARS-CoV-2 which limit the utility of traditional laboratory animals as mice (Mus musculus), rats (Rattus spp. ), rabbits and guinea pigs, since they do not have ACE2 receptors susceptible to SARS-CoV-2 binding.…”

Section: Micementioning

confidence: 99%

Bats, pangolins, minks and other animals - villains or victims of SARS-CoV-2?

et al. 2021

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is caused by the severe acute Respiratory syndrome coronavirus-2 (SARS-CoV-2), which has become unstoppable, spreading rapidly worldwide and, consequently, reaching a pandemic level. This review aims to provide the information available so far on the likely animal origin of SARS-CoV-2 and its possible hosts/reservoirs as well as all natural animal infections and experimental evidence using animal models. Horseshoe bats from the species Rhinolophus affinis seem to be a natural reservoir and pangolins (Manis javanica) appear to be an intermediate host of SARS-CoV-2. Humans remain the most likely spreading source of SARS-CoV-2 to other humans and also to domestic, zoo and farm animals. Indeed, human-to-animal transmission has been reported in cats, dogs, tigers, lions, a puma and minks. Animal-to-human transmission is not a sustained pathway, although mink-to-human transmission remains to be elucidated. Through experimental infections, other animals seem also to be susceptible hosts for SARS-CoV-2, namely ferrets, some non-human primate species, hamsters and transgenic mice, while dogs, pigs and poultry are resistant. A One Health perspective must be implemented in order to develop epidemiological surveillance and establish disease control mechanisms to limit zoonotic transmission. Moreover, research in this field is important to better understand SARS-CoV-2 and to obtain the long-awaited vaccine and specific treatment.

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Section: Micementioning

confidence: 99%

Bats, pangolins, minks and other animals - villains or victims of SARS-CoV-2?

et al. 2021

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“…In contrast, non-human primates, Syrian hamsters, ferrets, cats, and engineered chimeras, can mimic human infections and are promising animal models of SARS-CoV-2 infections. The challenges lie in the additional ethical justifications required to deal with non-human primate animal models, the scarcity of biosafety level III facilities, and the lack of trained personnel for executing such experiments [ 94 ].…”

Section: What Safety Challenges Do Anti-cov Nps Present?mentioning

confidence: 99%

COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles?

et al. 2021

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Every day, new information is presented with respect to how to best combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This manuscript sheds light on such recent findings, including new co-factors (i.e., neuropilin-1) and routes (i.e., olfactory transmucosal) allowing cell entry of SARS-CoV-2 and induction of neurological symptoms, as well as the new SARS-CoV-2 variants. We highlight the SARS-CoV-2 human–animal interfaces and elaborate containment strategies using the same vaccination (i.e., nanoparticle “NP” formulations of the BNT162b2 and mRNA-1273 vaccines) for humans, minks, raccoon dogs, cats, and zoo animals. We investigate the toxicity issues of anti-CoV NPs (i.e., plasmonic NPs and quantum dots) on different levels. Namely, nano–bio interfaces (i.e., protein corona), in vitro (i.e., lung cells) and in vivo (i.e., zebrafish embryos) assessments, and impacts on humans are discussed in a narrative supported by original figures. Ultimately, we express our skeptical opinion on the comprehensive administration of such antiviral nanotheranostics, even when integrated into facemasks, because of their reported toxicities and the different NP parameters (e.g., size, shape, surface charge, and purity and chemical composition of NPs) that govern their end toxicity. We believe that more toxicity studies should be performed and be presented, clarifying the odds of the safe administration of nanotoxocological solutions and the relief of a worried public.

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“…Os patógenos causadores de doenças infecciosas sofrem mutações e passam pelo salto de espécies, que permite que eles se adaptem e tenham as condições ambientais favoráveis para se reproduzirem no organismo humano. Como exemplo disso, pode-se citar a Síndrome Respiratória Aguda Grave (SARS), Síndrome Respiratória do Oriente Médio (MERS) e atualmente as Doenças do Coronavírus 2019 (COVID- 19), causada pelo Coronavírus SARS-2 ou mais comumente conhecida, SARS-CoV-2 (1).…”

Section: Introductionunclassified

Sars-Cov-2: Sua Relação Com Os Animais E Potencial Doença Zoonótica

Manzini

Rodrigues

Bertozzo

et al. 2021

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Os coronavírus (CoVs) estão em constante evolução e representam uma ameaça a saúde pública mundial por causarem surtos que podem ser fatais. Como exemplo, pode-se citar os vírus causadores das síndromes respiratórias SARS e MERS. O novo coronavírus SARS-CoV-2 que surgiu em 2019 em Wuhan, na China, é o terceiro surto de CoV em humanos e responsável por causar impactos negativos na saúde, como manifestações respiratórias, digestivas e sistemáticas. Diante da necessidade de maiores estudos acerca desta enfermidade, esta revisão objetivou reunir os dados sobre SARS-CoV-2 em animais, dada a grande probabilidade de salto de espécies associados aos morcegos, e também de estudos que demonstram que o SARS-CoV-2 pode ter tido origem em um reservatório animal, com destaque para os morcegos e pangolins. A vigilância deste microrganismo deve ser direcionada de modo a identificar os reservatórios do SARS-CoV-2 para melhor compreensão da patogênese e seus hospedeiros a fim de aumentar os conhecimentos a respeito deste vírus pandêmico.

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Animal Models to Study Emerging Technologies Against SARS-CoV-2

Cited by 10 publications

References 62 publications

Bats, pangolins, minks and other animals - villains or victims of SARS-CoV-2?

Bats, pangolins, minks and other animals - villains or victims of SARS-CoV-2?

COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles?

Sars-Cov-2: Sua Relação Com Os Animais E Potencial Doença Zoonótica

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