Anionic Polysaccharides From Phototrophic Microorganisms Exhibit Antiviral Activities to Vaccinia Virus

Radonić, Aleksandar; Thulke, Stefanie; Achenbach, John; Kurth, Andreas; Vreemann, Anna

doi:10.4172/jaa.1000023

Cited by 56 publications

(39 citation statements)

References 29 publications

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“…Radonic et al [36] and Chen et al [56] have reviewed the antiviral effects of several sPS on different host cell-lines. Calcium-Spirulan, an intracellular polysaccharide produced by A. platensis , inhibited the replication of several viruses in vitro by inhibiting the penetration of the virus into the different host cells used [40,43].…”

Section: The Polysaccharides From Marine Microalgae: From the Sourmentioning

confidence: 99%

“…Calcium-Spirulan, an intracellular polysaccharide produced by A. platensis , inhibited the replication of several viruses in vitro by inhibiting the penetration of the virus into the different host cells used [40,43]. Radonic and co-workers [36] also showed that the polysaccharide released into medium by A. platensis and P. purpureum exhibited antiviral activity in vitro and in vivo against two strains of Vaccinia virus and an Ectromelia virus.…”

Section: The Polysaccharides From Marine Microalgae: From the Sourmentioning

confidence: 99%

See 1 more Smart Citation

Bioactivity and Applications of Sulphated Polysaccharides from Marine Microalgae

2013

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Marine microalgae have been used for a long time as food for humans, such as Arthrospira (formerly, Spirulina), and for animals in aquaculture. The biomass of these microalgae and the compounds they produce have been shown to possess several biological applications with numerous health benefits. The present review puts up-to-date the research on the biological activities and applications of polysaccharides, active biocompounds synthesized by marine unicellular algae, which are, most of the times, released into the surrounding medium (exo- or extracellular polysaccharides, EPS). It goes through the most studied activities of sulphated polysaccharides (sPS) or their derivatives, but also highlights lesser known applications as hypolipidaemic or hypoglycaemic, or as biolubricant agents and drag-reducers. Therefore, the great potentials of sPS from marine microalgae to be used as nutraceuticals, therapeutic agents, cosmetics, or in other areas, such as engineering, are approached in this review.

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Section: The Polysaccharides From Marine Microalgae: From the Sourmentioning

confidence: 99%

Section: The Polysaccharides From Marine Microalgae: From the Sourmentioning

confidence: 99%

Bioactivity and Applications of Sulphated Polysaccharides from Marine Microalgae

2013

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“…A high therapeutic index (TI), or selectivity index (SI), is preferable for a drug to have a favorable safety and e cacy pro le. Radonic et al (2010) evaluate the effect of sulphur-containing exopolysaccharides from A. platensis (TKV3). According to their study, anionic polysaccharides from Arthrospira showed antiviral activity against enveloped virus such as VACV (EC 50 (TK V3) = 0.78 µg.mL -1 ) via interactions with viral membrane glycoproteins and thus inhibition of virus binding to host cells.…”

Section: Algae and Antiviral Activitiesmentioning

confidence: 99%

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Petit¹,

VERNES²,

Cadoret³

2020

Preprint

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Abstract A course is currently being launched as a result of the international health situation. This race aims to find, by various means, weapons to counter the Covid-19 pandemic now widespread on all continents. The aquatic world and in particular that of photosynthetic organisms is regularly highlighted but paradoxically little exploited in view of the tremendous possibilities it offers. Computational tools allow not only to clear the existence and activity of many molecules, but also to model their relationships with receptors identified in potential hosts. On a routine basis, our laboratory carries out a research activity on functionalities of molecules derived from algae, using in silico tools. We have implemented our skills, in algae biology and in modeling, as tests in order to identify molecules expressed by the genus Arthrospira showing an antiviral potential and more particularly anti SARS-CoV-2. Using Autodock Vina, we were able to identify 3 molecules: phycocyanobilin, phycoerythrobilin and folic acid. These 3 compounds showed binding energies able to compete with the SARS-CoV-2/ACE2 complex. Toxicity prediction as well as current regulations support their use as potential candidates for the fight against Covid-19.

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“…Similar to a rational drug design process in which drug-protein interactions are modeled in the computer, the rational probe design described here uses a set of criteria and publicly available bioinformatics software to select the desired probe molecules from libraries comprised of hundreds of thousands of probe molecules [44].Summary data from recent studies provide overwhelming evidence that bioinformatics tools are useful in protein interactions [45] microorganisms provide a large pool of bioactive compounds, and the intensive search for new drugs leads to the identification and structure determination of many novel compounds from these organisms [46].…”

Section: Bioinformaticsmentioning

confidence: 99%

J Microbial Biochem Technol

Srilatha¹

2011

J Microbial Biochem Technol

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Genomic investigations into the diversity of environmental microbes are leading to insights into ecological dynamics, the evolution of new forms of biological systems, and the discovery of new functions that might be exploited for biotechnological and biomedical purposes. It is now clear that an understanding of the community structure, function and evolution of bacteria in their natural environments is required to meet the promise of microbial biotechnology. To meet these new challenges, microbiologists are applying the tools of genomics and related highthroughput technologies to both cultured microbes and environmental samples. This work will lead to new views on ecosystems and biological function together with the biotechnology enabled by this science.

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Anionic Polysaccharides From Phototrophic Microorganisms Exhibit Antiviral Activities to Vaccinia Virus

Abstract: doi:10.4172/jaa.100002

Cited by 56 publications

References 29 publications

Bioactivity and Applications of Sulphated Polysaccharides from Marine Microalgae

Bioactivity and Applications of Sulphated Polysaccharides from Marine Microalgae

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

J Microbial Biochem Technol

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