Anisakis y pólipo en colon, una asociación infrecuente

Ruiz, Enrique Colás; Gausa, Manuel Alberto Lasala; García, Elena; Font, Juan Manuel Fernández; Cavanna, Jaime Martín; Cebrián, José María Fernández

doi:10.1016/j.gastrohep.2015.10.011

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…Infective L3 represent a public health risk for a zoonotic disease known as anisakidosis or anisakiasis [11], with an added theoretical risk of propagation of cetacean bacterial pathogens to human beings. Although a typical acute onset of anisakiasis in humans is usually caused by a single migrating larva, sometimes inferred only as an accidental finding during laparoscopy [12], recently, two cases in Europe have reported massive Anisakis spp. infection.…”

Section: Introductionmentioning

confidence: 99%

Microbiota and gut ultrastructure of Anisakis pegreffii isolated from stranded cetaceans in the Adriatic Sea

et al. 2019

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Background Inferring the microbiota diversity of helminths enables depiction of evolutionarily established ecological and pathological traits that characterize a particular parasite-host interaction. In turn, these traits could provide valuable information for the development of parasitosis control and mitigation strategy. The parasite Anisakis pegreffii (Nematoda: Anisakidae) realizes the final stage of its life-cycle within gastric chambers of aquatic mammals, causing mild-to-moderate granulomatous gastritis with eosinophilic infiltrate, to severe ulcerative gastritis with mixed inflammatory infiltrate, often associated with bacterial colonies. However, its interaction with the host microbiota remains unknown, and might reveal important aspects of parasite colonization and propagation within the final host. Methods MySeq Illumina sequencing was performed for the 16S rRNA gene from microbiota isolated from larvae, and uterus and gut of adult A. pegreffii parasitizing stranded striped dolphins ( Stenella coeruleoalba ). To assess the potential presence of Brucella ceti within isolated microbiota, Brucella -targeted real-time PCR was undertaken. In addition, TEM of the gastrointestinal tract of the infective third-stage (L3) and transitioning fourth-stage larvae (L4) was performed to characterize the morphological differences and the level of larval feeding activity. Results In total, 230 distinct operational taxonomic units (OTUs) were identified across all samples ( n = 20). The number of shared taxa was lower than the number of taxa found specifically in each parasite stage or organ. The dominant taxon was Mycoplasmataceae (genus Mycoplasma ) in the gut and uterus of adult A. pegreffii , whereas Fusobacteriaceae (genus Cetobacterium ) was the most abundant in 40% of larvae, alongside Mycoplasmataceae . No B. ceti DNA was detected in any of the microbiota isolates. TEM revealed differences in gut ultrastructure between L3 and L4, reflecting a feeble, most likely passive, level of feeding activity in L3. Conclusions Microbiota from L3 was more related to that of the gut rather than the uterus of adult A. pegreffii . Taxa of the larval microbiota showed qualitative and quantitative perturbations, likely reflecting the propagation through different environments during its life-cycle. This suggests an ontogenetic shift in the alpha and beta diversity of microbial communities from uterus-derived towards cetacean-derived microbiota. Although TEM did not reveal active L3 feeding, microbiota of the latter showed similar...

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Section: Introductionmentioning

confidence: 99%

Microbiota and gut ultrastructure of Anisakis pegreffii isolated from stranded cetaceans in the Adriatic Sea

et al. 2019

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Submucosal Necrotic Nodule of the Colon: An Enigmatic Entity Potentially Related to Anisakis Infection

González

Pastrián

Pyatibrat

et al. 2023

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Discrete submucosal necrotic nodules may rarely manifest as colon polyps. Objective.— To characterize the clinical and pathologic features of this lesion, which has been under-studied in the literature. Design.— We conducted an international search to compile a series. For each potential case, photomicrographs were centrally reviewed to confirm the diagnosis. We gathered clinical and pathologic information on each confirmed case. Results.— The final cohort included 25 patients, with 23 having 1 lesion and 2 having several (31 lesions total). Mean patient age was 62 years; 13 (52%) were male. Symptoms were nonspecific, although 4 patients (16%) had blood in stool; 14 patients were asymptomatic. Patient history and medications appeared noncontributory. Most cases were located in the right colon (n = 18; 58%). Mean size was 0.4 cm (range, 0.1–1.7 cm). Histology typically showed a centrally necrotic nodule with peripheral fibrosis, chronic inflammation, and sometimes palisading granulomatous inflammation. Percent necrosis ranged from 5% to 95% (average, 70%), and percent fibrosis ranged from 3% to 70% (average, 25%). In 3 cases, degenerated parasitic structures consistent with Anisakis could be seen on hematoxylin-eosin and trichrome special stain. No patient experienced disease recurrence. Conclusions.— Submucosal necrotic nodules can present as colon polyps. Most cases are unifocal, and patients do well on follow-up. At least some examples appear to be caused by Anisakis, implicating patient diet. Patients are often asymptomatic, and many cases show no histologic evidence of the causative agent.

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Anisakis y pólipo en colon, una asociación infrecuente

Cited by 2 publications

References 7 publications

Microbiota and gut ultrastructure of Anisakis pegreffii isolated from stranded cetaceans in the Adriatic Sea

Microbiota and gut ultrastructure of Anisakis pegreffii isolated from stranded cetaceans in the Adriatic Sea

Submucosal Necrotic Nodule of the Colon: An Enigmatic Entity Potentially Related to Anisakis Infection

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