Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila

Strilbytska, Olha; Zayachkivska, Alina; Koliada, Alexander; Galeotti, Fabio; Volpi, Nicola; Storey, Kenneth B.; Vaiserman, Alexander; Lushchak, Oleh

doi:10.3389/fphys.2020.596729

Cited by 12 publications

(12 citation statements)

References 52 publications

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“…This extension affected not only the median but also the maximum lifespan. Thus, this study joins others that have already shown a positive effect of algae and plant extracts in the Drosophila model [ 22 , 31 – 34 ]. To ensure that this is a true pharmacological effect and not a confounder based on reduced food intake, we investigated whether the extract affects food intake.…”

Section: Discussionsupporting

confidence: 81%

An aqueous extract of the brown alga Eisenia bicyclis extends lifespan in a sex-specific manner by interfering with the Tor-FoxO axis

Tahanzadeh

Knop

Seidler

et al. 2022

Aging

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Food has a decisive influence on our health, to the extent where even lifespan can be directly affected by it. In the present work, we have examined the effects of an aqueous extract of the marine brown alga Eisenia bicyclis in terms of its potential to extend lifespan. For this purpose, we used the fruit fly Drosophila melanogaster as a model. The experiments showed that small amounts of Eisenia extract can extend lifespan by up to 40%. This effect is not only related to the median but also to the maximum lifespan. Interestingly, this life-extending effect is sex-specific, i.e. it occurs exclusively in females. Even under stressful nutritional conditions such as a high sugar diet, this effect is detectable. Mechanistic studies showed that this life-prolonging effect depends on a functional Tor and a functional FoxO signaling pathway. It can be concluded that components of the Eisenia extract prolong lifespan by interacting with the Tor-FoxO axis. This study may serve to stimulate further investigations, which on the one hand show such a life-prolonging effect also in other organisms and on the other hand identify the substances responsible for this effect. Finally, it may also encourage the increased use of arame as a health-promoting food supplement.

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Section: Discussionsupporting

confidence: 81%

An aqueous extract of the brown alga Eisenia bicyclis extends lifespan in a sex-specific manner by interfering with the Tor-FoxO axis

Tahanzadeh

Knop

Seidler

et al. 2022

Aging

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“…Excessive nutrition is linked with severe health conditions and an enhanced aging mechanism [ 1 , 6 ]. Although it did not investigate hormetic effects, one particular study showed that anise hyssop ( Agastache foeniculum ) leaf powder extended the lifespan in a sex- and genotype-independent manner, increased fecundity, resistance to oxidative stress and starvation, enzymatic activities of superoxide dismutase, and aconitase, as well as elevated protein in Drosophila [ 45 ]. These results are in line with those obtained in our study.…”

Section: Discussionmentioning

confidence: 99%

Curcuma longa L. Prevents the Loss of β-Tubulin in the Brain and Maintains Healthy Aging in Drosophila melanogaster

Rahman¹,

Noman²,

Hossain³

et al. 2022

Mol Neurobiol

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Loss of tubulin is associated with neurodegeneration and brain aging. Turmeric (Curcuma longa L.) has frequently been employed as a spice in curry and traditional medications in the Indian subcontinent to attain longevity and better cognitive performance. We aimed to evaluate the unelucidated mechanism of how turmeric protects the brain to be an anti-aging agent. D. melanogaster was cultured on a regular diet and turmeric-supplemented diet. β-tubulin level and physiological traits including survivability, locomotor activity, fertility, tolerance to oxidative stress, and eye health were analyzed. Turmeric showed a hormetic effect, and 0.5% turmeric was the optimal dose in preventing aging. β-tubulin protein level was decreased in the brain of D. melanogaster upon aging, while a 0.5% turmeric-supplemented diet predominantly prevented this aging-induced loss of β-tubulin and degeneration of physiological traits as well as improved β-tubulin synthesis in the brain of D. melanogaster early to mid-age. The higher concentration (≥ 1%) of turmeric-supplemented diet decreased the β-tubulin level and degenerated many of the physiological traits of D. melanogaster. The turmeric concentration-dependent increase and decrease of β-tubulin level were consistent with the increment and decrement data obtained from the evaluated physiological traits. This correlation demonstrated that turmeric targets β-tubulin and has both beneficial and detrimental effects that depend on the concentration of turmeric. The findings of this study concluded that an optimal dosage of turmeric could maintain a healthy neuron and thus healthy aging, by preventing the loss and increasing the level of β-tubulin in the brain.

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“…Two‐day‐old flies were used to measure concentrations of glucose in hemolymph, body glucose, and glycogen levels as described earlier (Strilbytska et al, 2020). Preweighed flies were decapitated, with further centrifugation (3000 g , 6 min, 4°C) to extract hemolymph.…”

Section: Methodsmentioning

confidence: 99%

“…For the determination of Triacylglycerides (TAG) flies were weighted, homogenized in 200 mM PBST (phosphate‐buffered saline containing 0.05% Triton X‐100), boiled, and centrifuged (13,000 g , 10 min) (Strilbytska et al, 2020). The resulting supernatants were used for TAG assay with the Liquick Cor‐TG Diagnostic Kit (Cormay).…”

Section: Methodsmentioning

confidence: 99%

Herbicide Roundup shows toxic effects in nontarget organism Drosophila

Strilbytska

Semaniuk

Strutynska

et al. 2022

Arch Insect Biochem Physiol

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Glyphosate‐based herbicide Roundup, as the most employed herbicide used for multiple purposes in agriculture, adversely affects nontarget organisms. We tested the effects of Roundup applied at larval and adult stages. Roundup caused developmental delay and increased larvae mortality. Roundup treatment reduced hemolymph glucose and glycogen levels in adult flies of both sexes at the highest concentration tested. Sex‐dependent diverse effects were found in catalase and Cu,Zn superoxide dismutase (Cu,Zn‐SOD) activities. Decreased aconitase activity, contents of thiols, and lipid peroxides were found after larval Roundup exposure. Furthermore, chronic exposure to adult flies decreased appetite, body weight, and shortened lifespan. Thus, our results suggest that high concentrations of Roundup are deleterious to both larvae and adults, resulting in a shift of the metabolism and antioxidant defense system in Drosophila melanogaster.

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Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila

Cited by 12 publications

References 52 publications

An aqueous extract of the brown alga Eisenia bicyclis extends lifespan in a sex-specific manner by interfering with the Tor-FoxO axis

An aqueous extract of the brown alga Eisenia bicyclis extends lifespan in a sex-specific manner by interfering with the Tor-FoxO axis

Curcuma longa L. Prevents the Loss of β-Tubulin in the Brain and Maintains Healthy Aging in Drosophila melanogaster

Herbicide Roundup shows toxic effects in nontarget organism Drosophila

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