Ankaferd blood stopper accelerates deep second degree burn wound healing in rats

Topal, Ayşe; Satar, Nihal Y. Gul; Cangül, I. Taci; Oktay, M. Ayberk; Inan, Kivanc; Çeçen, Göksen; Akarsu, Emre; Can, Hakcahan

doi:10.2754/avb201887030261

Cited by 5 publications

(5 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[14] The comparison between the groups in our study showed that ABS was statistically significantly superior with respect to histopathological evaluation and recovery duration compared with the previously proven SSD. Kaya et al [16] and Topal et al [17] have previously demonstrated that even though the ABS and control groups are similar with respect to wound healing on day 7, ABS is statistically superior on day 14. In contrast, Topal et al [17] could not determine any difference between ABS and SSD in burn wounds.…”

Section: Discussionmentioning

confidence: 99%

“…Kaya et al [16] and Topal et al [17] have previously demonstrated that even though the ABS and control groups are similar with respect to wound healing on day 7, ABS is statistically superior on day 14. In contrast, Topal et al [17] could not determine any difference between ABS and SSD in burn wounds. On the other hand, in our study, ABS had a shorter recovery time than SSD based on 50% and 80% of re-epithelization rates.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Ankaferd Blood Stoper and Silver Sulfadiazine use in burn wounds: Experimental study.

Ünlü

2019

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

BACKGROUND: The present study was designed to compare the effectiveness of topical silver sulfadiazine (SSD) and Ankaferd Blood Stopper ® (ABS) usage in experimental partial-thickness burns in rats. METHODS: Twenty-one male Wistar albino rats weighing 250-290 (range: 270±19) g were used in the present study. A round brass probe that was specifically designed (3×3 cm diameter) was used to induce the burns in rats. After the presence of partial-thickness burns was confirmed, the rats were divided into three groups: Group 1 (ABS group) Ankaferd Blood Stopper ® pad, Group 2 (SSD group) silver sulfadiazine (Silverdin ®), and Group 3 (Control group) 1% isotonic saline solution-impregnated pad. The healing period was followed up clinically and histopathologically. The day on which 50% and 80% of re-epithelization at first were detected for each rat was also recorded. RESULTS: The mean times of 50% and 80% of re-epithelization at first were 10.8 days, 13.8 days, and 16.8 days in Groups 1, 2, and 3, respectively (p<0.001), and 16.4 days, 19.7 days, and 25.2 days, respectively (p<0.001). The mean inflammatory scores were also found to be better in the ABS group than in other groups (p<0.05). CONCLUSION: Our study showed that ABS has better results for the healing of the burn wound than SSD in experimental partialthickness burns in rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of Ankaferd Blood Stoper and Silver Sulfadiazine use in burn wounds: Experimental study.

Ünlü

2019

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

show abstract

“…They reported that the mean percentage of wound contraction in the ABS and SSD groups was significantly higher at 14, 21 and 28 days than in the control group. They reported that, wound healing is characterized by a decrease in neutrophil count and an increase in vascular count, and that ABS, as well as SSD, can be successfully used in burn wound healing [24]. In a study by Akalin et al, they created a full-thickness wound defect and applied ABS.…”

Section: Kido Et Al Created Diabetes By Applying Streptozotocin Tomentioning

confidence: 99%

The effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper on the diabetic and nondiabetic gingival wound healing: an experimental study

Gul¹,

Dündar²,

Artaş³

et al. 2021

Turk J Med Sci

View full text Add to dashboard Cite

Background/aim Healthy wound healing is very important for patient comfort. Diabetes is one of the factors that negatively affect wound healing. Ankaferd Blood Stopper (ABS) and caffeic acid phenethyl ester (CAPE) are antiinflammatory and antimicrobial agents and may have positive effects on wound healing. Materials and methods In this study, 72 male Wistar albino rats were used. Rats; control, CAPE, ABS, diabetes + control, diabetes + ABS and diabetes + CAPE groups were divided into 6 groups. A healthy 36 rats created diabetes using streptozotocin (STZ). A gingival wound was created using a 4-mm punch biopsy in the gingival tissue under the lower anterior incisors of the rats. Results The comparison between the nondiabetic groups had a statistically significant positive effect compared to the control group of CAPE and ABS (P ˂ 0.05). In the comparison between ABS and diabetes + ABS groups and in the comparison between CAPE and diabetes + CAPE groups, a decrease in vascularization in diabetes + CAPE groups was observed and it was statistically significant (P ˂ 0.005). Conclusion ABS and CAPE have been found to have positive effects on gingival wound healing in the nondiabetic group. We think that this situation is caused by its antiinflammatory and antimicrobial properties.

show abstract

“…They showed that the mean percentage of wound contraction in the ABS and SSD groups was significantly higher than in the control group on days 14, 21, and 28 and suggested that ABS could be successfully used for burn wound healing besides (SSD). 52 ABS can improve the wound-healing process via providing inhibition of extra cellular matrix-degrading enzymes during wound repair. Moreover, ABS enhanced the stimulated migration of 3T3 fibroblasts to an artificial wounded area.…”

Section: Ankaferd Hemostat (Abs) In Wound Healingmentioning

confidence: 99%

Pharmacobiological management of hemostasis within clinical backgrounds via Ankaferd hemostat (Ankaferd blood stopper)

et al. 2020

View full text Add to dashboard Cite

Ankaferd hemostat (Ankaferd blood stopper [ABS], Istanbul, Turkey) is a hemostatic agent affecting red blood cell-fibrinogen interactions. ABS has been traditionally used in Anatolia as a hemostatic agent for centuries. ABS contains a standardized combination of the plants namely Glycyrrhiza glabra, Thymus vulgaris, Alpinia officinarum, Vitis vinifera, and Urtica dioica. The hemostatic effect of ABS depends upon the quick promotion of a protein network, particularly fibrinogen gamma, in relation to the erythrocyte aggregation. The aim of this review is to indicate pharmacobiological basis and clinical backgrounds of ABS. Current perspective for using ABS is to provide hemostasis and accelerating wound healing particularly in cases which are difficult to manage. Future controlled trials are needed to elucidate the actions of ABS with in hemostasis, antithrombotic, anti-inflammatory, anti-infective, antifungal, and anti-oxidative effects.

show abstract

Ankaferd blood stopper accelerates deep second degree burn wound healing in rats

Cited by 5 publications

References 22 publications

Comparison of Ankaferd Blood Stoper and Silver Sulfadiazine use in burn wounds: Experimental study.

Comparison of Ankaferd Blood Stoper and Silver Sulfadiazine use in burn wounds: Experimental study.

The effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper on the diabetic and nondiabetic gingival wound healing: an experimental study

Pharmacobiological management of hemostasis within clinical backgrounds via Ankaferd hemostat (Ankaferd blood stopper)

Contact Info

Product

Resources

About