Ankaferd Blood Stopper: Does it have a role in fracture healing?

Abstract

High-pressure and ultrahigh-pressure metamorphic rocks crop out widely in the northern Aegean. In many instances their ages and tectonic setting are poorly constrained. Here we report newly discovered high-pressure rocks of continental crustal origin and of Late Cretaceous age southwest of the Marmara Sea. Th ey occur at the contact between the Rhodope-Strandja Zone in the north and the Sakarya Zone in the south.Th e Kemer Metamorphic Complex is composed mainly of mica schist, calcschist and marble with minor metabasite and serpentinite. Th e mica schists contain garnet, phengite (3.30-3.44 c.p.f.u), (±) paragonite, albite, epidote, calcite, chlorite and titanite. Th e high-pressure metamorphic origin of the mica schists is shown by the high silica contents of the white micas and by glaucophane inclusions in garnet. In the metabasites the mineral assemblage is garnet, barroisite, epidote, albite, titanite, quartz, phengite and chlorite; no evidence is left for the former presence of high-pressure minerals. Metamorphic conditions are constrained by mineral equilibria: a 560-640°C temperature at a minimum pressure of 10 kbar. Th e metamorphism is dated at 64-84 Ma by the Rb-Sr phengite-whole rock method.Th e Kemer Metamorphic Complex is in tectonic contact with an accretionary ophiolitic mélange consisting of limestone, basalt, serpentinite, greywacke, radiolarian chert and metabasite. Some of the metabasites in the mélange contain Na-amphibole and lawsonite, indicating a subduction origin. Th e ages of the limestone blocks in the mélange range from Late Triassic to Late Cretaceous and that of the radiolarite blocks from Middle Jurassic to Early Cretaceous, indicating an oceanic domain dating back to Late Triassic at least. Th e Kemer Metamorphic Complex and the Çetmi Mélange are intruded by a granodiorite of Early Eocene (52 Ma) age and are unconformably covered by a Late Eocene volcano-sedimentary succession.Th e lithology of the Kemer Metamorphic Complex resembles a continental margin rather than an oceanic accretionary complex. Th is and the presence of a Late Cretaceous magmatic arc in the north (Sredna-Gora-Pontide) suggest that the Kemer metamorphic rocks were initially deposited on the northern passive margin of the Sakarya Zone, which was subducted under the Rhodope-Strandja continental domain.

Investigation of the effect of combined use of alloplastic-based tricalcium phosphate bone graft and antihemorrhagic plant extract (ABS) on bone regeneration in surgically induced bone defects in nondiabetic rats: an experimental animal study

“…A statistically significant difference between the ABS and control groups indicates that ABS is effective both in early and late bone healing. This is not consistent with the studies of Şimşek et al (24) and Günay et al (28). In our study, histologic scores of nondiabetic rats on day 56 were compared.…”

Structural properties of fracture haematoma: current status and future clinical implications

“…Furthermore, in a sheep tibial osteotomy model, when fracture haematomas were removed at 4 and 7 days, the result was a significant delay of early fracture healing (Peters and Duda, ). These findings are clear indications that a stable haematoma is crucial for initial bone healing (Günay et al ., ; Van der Ende et al ., ).…”

Manipulating fibrin structure of hematomas enhances large bone defects healing

“…Similarly, delayed bone healing ensued when the hematomas in open osteotomies in the middle tibia of rabbits were repeatedly removed by irrigation and debridement (Park et al, 2002). These and similar findings indicate that stable hematomas are crucial for initial bone healing (GÜNAY et al, 2013;Van der Ende et al, 2013).…”

“…Furthermore, in a sheep tibial osteotomy model, when fracture hematomas were removed at 4 and 7 days the result was a significant delay of early fracture healing (Peters et al, 2012). These findings are clear indications that a stable hematoma is crucial for the initial bone healing (GÜNAY et al, 2013;Van der Ende et al, 2013).…”