Ankylosing spondylitis

Edavalath, Mukesh

doi:10.4103/0975-9476.72619

Cited by 12 publications

(8 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 1 Previous studies indicated a strong correlation of AS and genetic marker HLA-B27. 2 Rather than functional impairment, there is involvement of entheses, peripheral joints and extra-articular organs, reduction of health-related quality of life (HRQoL). 3 Stiffness, pain, progressive loss of spine mobility may be key contributors to physical limitations for AS patients.…”

Section: Introductionmentioning

confidence: 99%

“… 14 Exercises seem to play an important role in management AS patients, particularly when performed in an outpatient group supervised by a physiotherapist or intensively in inpatients who showed a short-term improvement. 15 , 16 Nowadays, all kinds of forms of exercises such as educational sessions, supervised exercise, home-based exercise, spa, swimming, the Global Posture Reeducation method, Tai Chi, McKenzie, Heckscher, and Pilates methods, 17 yoga 2 and so on had been embedded in rehabilitation program for AS patients. 11 Some studies evaluated the impact of exercises on AS patients who did not receive prescribed TNF inhibitors 17 – 19 and obtained consistent result that exercises improved the clinical outcomes of AS patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Concurrent Intervention With Exercises and Stabilized Tumor Necrosis Factor Inhibitor Therapy Reduced the Disease Activity in Patients With Ankylosing Spondylitis

Liang

Zhang

et al. 2015

Medicine

View full text Add to dashboard Cite

Since the use of tumor necrosis factor (TNF) inhibitor therapy is becoming wider, the effects of concurrent intervention with exercises and stabilized TNF inhibitors therapy in patients with ankylosing spondylitis (AS) are different. The study aimed to objectively evaluate whether concurrent intervention with exercises and stabilized TNF inhibitors can reduce the disease activity in patients with AS.A search from PubMed, Web of Science, EMBASE, and the Cochrane Library was electronically performed to collect studies which compared concurrent intervention with exercise and TNF inhibitor to conventional approach in terms of disease activity in patients with AS published from their inception to June 2015. Studies that measured the Bath Ankylosing Spondylitis Functional Index (BASFI), the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Metrology Index (BASMI), and chest expansion as outcomes were included. Two independent investigators screened the identified articles, extracted the data, and assessed the methodological quality of the included studies. Quantitative analysis was performed with Review Manager (RevMan) software (version 5.3.0).A total of 5 studies comprising 221 participants were included in the study. Meta-analyses showed that concurrent intervention with exercises and stabilized TNF inhibitors therapy significantly reduced the BASMI scores (MD, −0.99; 95% CI, −1.61 to −0.38) and BASDAI scores (MD, −0.58; 95% CI, −1.10 to −0.06), but the BASFI scores (MD, −0.31; 95% CI, −0.76 to 0.15) was not reduced, and chest expansion (MD, 0.80; 95% CI, −0.18 to 1.78) was not increased.Concurrent intervention with exercises and stabilized TNF inhibitors therapy can reduce the disease activity in patients with AS. More randomized controlled trials (RCTs) with high-quality, large-scale, and appropriate follow-up are warranted to further establish the benefit of concurrent intervention with exercises and TNF inhibitors for this given population due to some limitations impaired the power of our study.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Concurrent Intervention With Exercises and Stabilized Tumor Necrosis Factor Inhibitor Therapy Reduced the Disease Activity in Patients With Ankylosing Spondylitis

Liang

Zhang

et al. 2015

Medicine

View full text Add to dashboard Cite

show abstract

“…Various panchakama procedures and internal Ayurvedic medicines have been proved beneficial in the management of AS [4]. Previously published case reports has correlated AS with 'Asthi-majja gata vata', 'Amavata' according to Ayurveda and managed AS successfully with various panchakarma procedures and internal Ayurvedic medicines [4,5]. Here we are reporting a case of AS with 'Beta thalassemia' diagnosed as 'Asthi-majja gata vata' according to Ayurveda.…”

Section: Non-steroidalmentioning

confidence: 95%

Ayurvedic Management of Ankylosing Spondylitis–A Case Report

Mamidi¹

2017

IJCAM

View full text Add to dashboard Cite

Ankylosing spondylitis (AS) is a chronic, systemic, inflammatory disease which affects primarily sacro-iliac joints and spine. AS is a gradually progressive condition over several years until structural damage manifests clinically as sacroiliitis, loss of spinal mobility, extra-articular symptoms, peripheral arthritis and reduced quality of life. Various panchakama procedures and internal Ayurvedic medicines have been proved beneficial in the management of AS. The present report deals with a case of ' Ankylosing spondylitis' with 'Beta thalassemia' came to our care for Ayurvedic treatment. Patient was diagnosed as having 'Asthi-majja gata vata' according to Ayurveda and treated with various panchakarma procedures and internal medicines for 6 months. A criterion of assessment was based on the scoring of 'Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)'. Total two assessments were carried out before and after 6 months of treatment. Patient has showed good improvement on BASDAI (80% relief). Improvement was found in signs and symptoms like, fatigue/tiredness, neck/ back/hip pain, tenderness and intensity as well as duration of morning stiffness. Ayurvedic treatment seems to be promising in the management of AS without causing any adverse effects.

show abstract

“…pondylitis belongs to a group of rheumatic diseases known as spondyloarthropathies (SpA) (1). It is believed that the primary mechanism of its occurrence is autoimmunity or autoinflammation (2); hat is, it is a chronic inflammatory autoimmune disease that primarily affects the axial spine, with the hallmark of sacroiliitis, involving the adjacent joints, tendons, and ligaments.…”

Section: Introductionmentioning

confidence: 99%

Serum levels of CXCL-8, IL-10, and TNF-alpha in ankylosing spondylitis patients

Karim¹

2021

Biomedicine

View full text Add to dashboard Cite

The mean age of AS patients was (35.0 ± 9.8) years.When the patients and control subjects were divided into different age groups (>40, 30-40, <30 years), the differences were not significantin terms of disease prevalence. The results also showed that the percentage of male patients is higher than that of females. There was no significant difference (P?0.05) between patients and controls in the distribution of males and females.Most of the patients had the disease for a period of 5 years or higher, with a disease severity of ? 2.1 and functional disability degree of I, II. The resultsshoweddifferent patterns of distribution for the three tested cytokines. A significant increase in the level of TNF-?, anon-significantincrease in the level of CXCL-8, and a significant decrease in the level of IL-10 were observed in the sera of patients with AS compared with the control.The patients also demonstrated significant decreases in the serum ALT and AST enzyme levels, hemoglobin (Hb) level, white blood cells (WBC) count, and erythrocyte sedimentation rate (ESR) (P?0.05).The percentage of HLA-B27-positive Iraqi patients was lower than that of the HLA-B27-negative patients. Some of these patterns were also exposed to changes related to some determinants in patients, which included age, sex, disease duration, disease severity, functional disability, and HLA-B27 positivity,along with association with clinical subtypes of AS.The area under the curve was determined for the parameters of ESR, IL-10, TNF-? and CXCL-8.The most significant factor was found to beESR, followed by IL-10, and then TNF-?, with the presence of significant differences, while there was no diagnostic significance for CXCL-8 ,which showed no significant difference (p?0.05).

show abstract

Ankylosing spondylitis

Cited by 12 publications

References 4 publications

Concurrent Intervention With Exercises and Stabilized Tumor Necrosis Factor Inhibitor Therapy Reduced the Disease Activity in Patients With Ankylosing Spondylitis

Concurrent Intervention With Exercises and Stabilized Tumor Necrosis Factor Inhibitor Therapy Reduced the Disease Activity in Patients With Ankylosing Spondylitis

Ayurvedic Management of Ankylosing Spondylitis–A Case Report

Serum levels of CXCL-8, IL-10, and TNF-alpha in ankylosing spondylitis patients

Contact Info

Product

Resources

About