Rheumatological diseases causing systemic vasculitis are one the causes of stroke in young patients.AS is a systemic inflammatory rheumatological disorder that primarily involves axial skeleton. AS may cause premature atherosclerosis. In addition, small vessel inflammation may play a role in the pathogenesis of vascular disease in patients with AS. Association of AS and cerebrovascular disease is rare. Herein, we discussed the role of AS as an etiological factor for recurrent stroke in young patient.