Ankylosing spondylitis in a nonhuman primate: a monkey tale

Adams, Ronita; Flinn, George S.; Douglas, Mike

doi:10.1002/art.1780300822

Cited by 19 publications

(12 citation statements)

References 10 publications

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“…Therefore, we determined the MHC type of 10 additional unrelated, unaffected gorillas and found that Gogo-B01 is expressed in nearly every animal (Table VIII). These results could account for the high rate of cross-reactivity between gorilla lymphocytes and human B27 heteroantisera previously observed by other groups (18,23). We also tested human B27 antisera against PBLs from ␤ and T cell blasts from another gorilla, Pattycake, and observed similar cross-reactivity (data not shown).…”

Section: Gogo-b01 Is Present In Nearly Every Gorillasupporting

confidence: 77%

“…Description of AS in Beta and ReA in Holli and Husani was reported previously (18,19). The clinical report of ReA in Harry is in preparation (D. Neiffer et al, manuscript in preparation).…”

Section: Animalsmentioning

confidence: 80%

“…The case description of Beta's AS was the first in a nonhuman primate (18) (Table I). She was initially diagnosed with arthritis in 1979 when radiographs were taken due to a stiffness in her gait.…”

Section: Gorillas That Develop Spas Express An Mhc Class I Molecule Wmentioning

confidence: 99%

“…Previously, other groups described AS in the gorilla, Beta (18), and post shigellosis ReA in Holli and Husani (19). Another gorilla, Harry, also developed ReA (D. Neiffer, manuscript in preparation).…”

mentioning

confidence: 94%

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Gorillas with Spondyloarthropathies Express an MHC Class I Molecule with Only Limited Sequence Similarity to HLA-B27 that Binds Peptides with Arginine at P2

Urvater

Hickman

Dzuris³

et al. 2001

The Journal of Immunology

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The human MHC class I gene, HLA-B27, is a strong risk factor for susceptibility to a group of disorders termed spondyloarthropathies (SpAs). HLA-B27-transgenic rodents develop SpAs, implicating HLA-B27 in the etiology of these disorders. Several nonhuman primates, including gorillas, develop signs of SpAs indistinguishable from clinical signs of humans with SpAs. To determine whether SpAs in gorillas have a similar HLA-B27-related etiology, we analyzed the MHC class I molecules expressed in four affected gorillas. Gogo-B01, isolated from three of the animals, has only limited similarity to HLA-B27 at the end of the α1 domain. It differs by several residues in the B pocket, including differences at positions 45 and 67. However, the molecular model of Gogo-B*0101 is consistent with a requirement for positively charged residues at the second amino acid of peptides bound by the MHC class I molecule. Indeed, the peptide binding motif and sequence of individual ligands eluted from Gogo-B*0101 demonstrate that, like HLA-B27, this gorilla MHC class I molecule binds peptides with arginine at the second amino acid position of peptides bound by the MHC class I molecule. Furthermore, live cell binding assays show that Gogo-B*0101 can bind HLA-B27 ligands. Therefore, although most gorillas that develop SpAs express an MHC class I molecule with striking differences to HLA-B27, this molecule binds peptides similar to those bound by HLA-B27.

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Section: Gogo-b01 Is Present In Nearly Every Gorillasupporting

confidence: 77%

“…Description of AS in Beta and ReA in Holli and Husani was reported previously (18,19). The clinical report of ReA in Harry is in preparation (D. Neiffer et al, manuscript in preparation).…”

Section: Animalsmentioning

confidence: 80%

Section: Gorillas That Develop Spas Express An Mhc Class I Molecule Wmentioning

confidence: 99%

mentioning

confidence: 94%

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Gorillas with Spondyloarthropathies Express an MHC Class I Molecule with Only Limited Sequence Similarity to HLA-B27 that Binds Peptides with Arginine at P2

Urvater

Hickman

Dzuris³

et al. 2001

The Journal of Immunology

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“…2,192 OA was present in spine and other joints when she died at 47 yo (Gorilla SSP data). Her son developed acute IA of the wrist.…”

Section: Arthritis In Captive Apesmentioning

confidence: 99%

Comparative Pathology of Aging Great Apes

2015

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The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives. Despite the many similarities, there are significant differences in aging among apes, including the human ape. Common to all are dental attrition, periodontitis, tooth loss, osteopenia, and arthritis, although gout is uniquely human and spondyloarthropathy is more prevalent in apes than humans. Humans are more prone to frailty, sarcopenia, osteoporosis, longevity past reproductive senescence, loss of brain volume, and Alzheimer dementia. Cerebral vascular disease occurs in both humans and apes. Cardiovascular disease mortality increases in aging humans and apes, but coronary atherosclerosis is the most significant type in humans. In captive apes, idiopathic myocardial fibrosis and cardiomyopathy predominate, with arteriosclerosis of intramural coronary arteries. Similar cardiac lesions are occasionally seen in wild apes. Vascular changes in heart and kidneys and aortic dissections in gorillas and bonobos suggest that hypertension may be involved in pathogenesis. Chronic kidney disease is common in elderly humans and some aging apes and is linked with cardiovascular disease in orangutans. Neoplasms common to aging humans and apes include uterine leiomyomas in chimpanzees, but other tumors of elderly humans, such as breast, prostate, lung, and colorectal cancers, are uncommon in apes. Among the apes, chimpanzees have been best studied in laboratory settings, and more comparative research is needed into the pathology of geriatric zoo-housed and wild apes. Increasing longevity of humans and apes makes understanding aging processes and diseases imperative for optimizing quality of life in all the ape species.

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Old world spondylarthropathy: the gorilla connection

Rothschild

Woods

1988

Arthritis & Rheumatism

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Ankylosing spondylitis in a nonhuman primate: a monkey tale

Cited by 19 publications

References 10 publications

Gorillas with Spondyloarthropathies Express an MHC Class I Molecule with Only Limited Sequence Similarity to HLA-B27 that Binds Peptides with Arginine at P2

Gorillas with Spondyloarthropathies Express an MHC Class I Molecule with Only Limited Sequence Similarity to HLA-B27 that Binds Peptides with Arginine at P2

Comparative Pathology of Aging Great Apes

Old world spondylarthropathy: the gorilla connection

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