Ankylosing Spondylitis in Association With Mitral Stenosis, Mitral Regurgitation, and Aortic Regurgitation: A Case Report and Review of the Literature

Abstract

We report on a patient with ankylosing spondylitis in association with mitral stenosis, mitral regurgitation, and aortic regurgitation. Despite extensive search of literature, we could not find association of mitral stenosis with ankylosing spondylitis. This report is the first to describe this association. Our findings are based on clinical and echocardiographic findings.

Ventricular Diastolic Function of Ankylosing Spondylitis Patients by Using Conventional Pulsed Wave Doppler, Myocardial Performance Index and Tissue Doppler Imaging

“…The most commonly encountered valve disease in ankylosing spondylitis patients are the aortic and mitral insufficiency. 31,44 Valvular disease, especially aortic stenosis, may contribute to the impairment of diastolic functions. 45 In our study mild valvular abnormalities were observed in only few subjects, both in the patient and control groups.…”

“…The most commonly encountered valve disease in ankylosing spondylitis patients are the aortic and mitral insufficiency 31, 44 . Valvular disease, especially aortic stenosis, may contribute to the impairment of diastolic functions 45 .…”

Severe Mitral and Aortic Regurgitation in Association with Ankylosing Spondylitis

“…Mitral stenosis in association with ankylosing spondylitis has been reported on a single occasion. 10 This occurred in association with mitral and aortic regurgitation and was postulated to relate to fibrous thickening of the mitral valve leaflets resulting in restricted opening. It is impossible, however, to exclude intercurrent rheumatic fever as a cause of the valvular abnormalities in this report.…”