Anmeldelse: Migrationslitteratur

Simonsen, Karen‐Margrethe

doi:10.7146/kok.v39i112.15750

Cited by 3 publications

(4 citation statements)

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“…The full screening was conducted with the UHPLC-TOF-MS method described in this paper, together with the UHPLC-MS/MS THC method. All positive findings were further verified and quantified with in-house developed LC-MS/MS methods [26][27][28]. The re-sults were compared to the Danish fixed limits (https://www.…”

Section: Analysis Of Duid Casesmentioning

confidence: 99%

Screening for illicit and medicinal drugs in whole blood using fully automated SPE and ultra‐high‐performance liquid chromatography with TOF‐MS with data‐independent acquisition

Pedersen

Dalsgaard

Rode

et al. 2013

J of Separation Science

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A broad forensic screening method for 256 analytes in whole blood based on a fully automated SPE robotic extraction and ultra-high-performance liquid chromatography (UHPLC) with TOF-MS with data-independent acquisition has been developed. The limit of identification was evaluated for all 256 compounds and 95 of these compounds were validated with regard to matrix effects, extraction recovery, and process efficiency. The limit of identification ranged from 0.001 to 0.1 mg/kg, and the process efficiency exceeded 50% for 73 of the 95 analytes. As an example of application, 1335 forensic traffic cases were analyzed with the presented screening method. Of these, 992 cases (74%) were positive for one or more traffic-relevant drugs above the Danish legal limits. Commonly abused drugs such as amphetamine, cocaine, and frequent types of benzodiazepines were the major findings. Nineteen less frequently encountered drugs were detected e.g. buprenorphine, butylone, cathine, fentanyl, lysergic acid diethylamide, m-chlorophenylpiperazine, 3,4-methylenedioxypyrovalerone, mephedrone, 4-methylamphetamine, p-fluoroamphetamine, and p-methoxy-N-methylamphetamine. In conclusion, using UHPLC-TOF-MS screening with data-independent acquisition resulted in the detection of common drugs of abuse as well as new designer drugs and more rarely occurring drugs. Thus, TOF-MS screening of blood samples constitutes a practical way for screening traffic cases, with the exception of δ-9-tetrahydrocannabinol, which should be handled in a separate method.

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Section: Analysis Of Duid Casesmentioning

confidence: 99%

Screening for illicit and medicinal drugs in whole blood using fully automated SPE and ultra‐high‐performance liquid chromatography with TOF‐MS with data‐independent acquisition

Pedersen

Dalsgaard

Rode

et al. 2013

J of Separation Science

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“…The mean recoveries of zopiclone were 63.9 [5], 50.6 [17] and 38.8% [23], and the mean recovery of zaleplon was 6.0% [24]. In some previously published methods slightly wider accuracy limits for determination of zaleplon of -14.6 to 23.8% [6] and -11.7 to 4.0% [10], and for zopiclone -5.0 to 14.0% [6] and -12.7 to 16.6% [24] have been presented. However, some methods published previously have shown quite high LOQs: 5 [8,12], 10 [11,24] or 20 ng/mL [10] for zaleplon, while 10 ng/mL [11,12,24] or 20 ng/g [17] for zopiclone.…”

Section: Validation Of the Methodsmentioning

confidence: 99%

“…Determination of the analytes in human plasma by RP HPLC with UV [4] or fluorescence detection [5] has been demonstrated. Finally, LC-MS/MS [6] or atmospheric pressure chemical ionization MS [7,8] determination of both analytes have been reported. Several methods have been described for the detection of the analytes by GC with electron impact MS [9,10] or electron capture ionization techniques [11], and GC with negative-ion chemical ionization (NICI) MS [12].…”

Section: Introductionmentioning

confidence: 99%

“…The standard procedure for extracting both analytes is based on a liquid-liquid extraction before alkalinization with 0.63 M borate buffer [6], 2.0 M sodium hydroxide solution [7] or 0.5 M phosphate buffer [10][11][12]. A variety of organic solvents, such as, ethyl acetate [6,7], a mixture of diethyl ether and ethyl acetate (1:1 v/v) [8] or n-butyl acetate [10][11][12] were used for liquid-liquid extraction with sufficient extraction efficiency (≥80%). When insufficient extraction [5,17] was applied, the extraction efficiency for zopiclone was found to be low (≤65%).…”

Section: Introductionmentioning

confidence: 99%

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Development of an SPE method for the determination of zaleplon and zopiclone in hemolyzed blood using fast GC with negative-ion chemical ionization MS

2014

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An SPE procedure for the determination of zaleplon and zopiclone in low-volume human hemolyzed blood using fast GC with negative-ion chemical ionization MS has been developed and validated. Both analytes were well retained on Oasis MCX and HLB columns, and sufficient extraction efficiency was achieved at pH 9.0. For further study a hydrophilic-lipophilic sorbent Oasis HLB was selected due to the polarity of sorbent surface and its large surface area in order to achieve efficient extraction of both analytes in a single step. Special attention has been paid to choosing washing and eluting solvents, resulting in a particularly/extremely clean and moisture-free extract. The mean extraction efficiency was higher than 90.1% for zaleplon and 82.9% for zopiclone. The precision for zaleplon and zopiclone was between 3.04-10.58% and 4.08-9.52%, respectively. Whereas the accuracy was in the range from -5.73 to 6.00%, and from -7.00 to 6.32% for zaleplon and zopiclone, respectively. The results show that the developed method is accurate, selective, precise, and very fast with excellent recovery and low LOD and LOQ.

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Research Progress on Sprouting Regeneration of Woody Plants

范¹

2021

IJE

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Anmeldelse: Migrationslitteratur

Abstract: Anmeldelse af SØREN FRANK, 2008Migration and Literature(New York: Palgrave MacMillan, 248sider)

Cited by 3 publications

References 0 publications

Screening for illicit and medicinal drugs in whole blood using fully automated SPE and ultra‐high‐performance liquid chromatography with TOF‐MS with data‐independent acquisition

Screening for illicit and medicinal drugs in whole blood using fully automated SPE and ultra‐high‐performance liquid chromatography with TOF‐MS with data‐independent acquisition

Development of an SPE method for the determination of zaleplon and zopiclone in hemolyzed blood using fast GC with negative-ion chemical ionization MS

Research Progress on Sprouting Regeneration of Woody Plants

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