Annexin A1 protects epidermal stem cells against ultraviolet-B irradiation-induced mitochondrial dysfunction

Ge, Lingzhi; Chen, Wenfang; Wei, Fangli

doi:10.1007/s00403-024-02875-8

Arch Dermatol Res

2024

DOI: 10.1007/s00403-024-02875-8

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Annexin A1 protects epidermal stem cells against ultraviolet-B irradiation-induced mitochondrial dysfunction

Lingzhi Ge,

Wenfang Chen,

Fangli Wei

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Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy

Cheng,

Wang,

Lin

et al. 2024

Advanced Science

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Four to eight percent of patients with head and neck cancer will develop osteoradionecrosis of the jaw (ORNJ) after radiotherapy. Various radiation‐induced tissue injuries are associated with reactive oxygen and nitrogen species (RONS) overproduction. Herein, Fe doping is used in VOx (Fe‐VOx) nanozymes with multienzyme activities for ORNJ treatment via RONS scavenging. Fe doping can induce structure reconstruction of nanozymes with abundant defect production, including Fe substitution and oxygen vacancies (OVs), which markedly increased multiple enzyme‐mimicking activity. Catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) enzyme‐like performance of Fe‐VOx can effectively reprogram jawbone microenvironment to restore mitochondrial dysfunction and enhance mitophagy. Moreover, the surface plasmon resonance (SPR) effect of Fe‐VOx made it a good photothermal nanoagents for inhibiting jaw infection. Thus, this work demonstrated that Fe‐VOx nanozymes can efficiently scavenge RONS, activate mitophagy, and inhibit bacteria, which is potential for ORNJ treatment.

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Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy

Cheng,

Wang,

Lin

et al. 2024

Advanced Science

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show abstract

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Annexin A1 protects epidermal stem cells against ultraviolet-B irradiation-induced mitochondrial dysfunction

Cited by 1 publication

References 40 publications

Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy

Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy

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