Annexin A7 gene is an important factor in the lymphatic metastasis of tumors

Jin, Yanling; Wang, Zhiqiang; Qu, Hong; Wang, Huan-Xi; Ibrahim, Mohammed Mohammed; Zhang, Jun; Huang, Yühong; Wu, Jun; Bai, Lulu; Meng, Jinyi; Tang, Jianwu

doi:10.1016/j.biopha.2012.11.006

Cited by 19 publications

(24 citation statements)

References 41 publications

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“…These results indicated that ANXA7 could promote proliferation, and increase migration and invasion in mouse hepatocarcinoma cell line. The downregulating ANXA7 in the gene level by RNAi technique has been confirmed by our previous studies [4][5][6][7]9]. In this study, we showed a decreased expression of ANXA7 by using anti-ANXA7 antibody in the protein level.…”

Section: Discussionsupporting

confidence: 90%

“…Our previous studies showed that the downregulating ANXA7 could inhibit proliferation, and reduce migration and invasion in Hca-F cell line with high lymphatic metastatic potential [6,7]. In this study, we tested whether the proliferation, migration and invasion were also effected on in Hca-P cell line with low lymphatic metastatic potential.…”

Section: Discussionmentioning

confidence: 90%

“…Our previous studies have also indicated that 33 genes, such as ANXA7, Sorcin, Gelsolin showed different expressions in both gene and protein levels in Hca-F and Hca-P cell lines [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…A couple of cell lines with different lymphatic metastatic potentials, Hca-F cell line (lymphatic metastasis rate > 70%) and Hca-P cell line (lymphatic metastasis rate < 30%) have been set up in our lab from hepatocarcinoma in the mouse and have been proved to be ideal models for studying hepatocarcinoma lymphatic metastasis as described in our lab [2][3][4][5][6][7][8][9]. Our previous studies have also indicated that 33 genes, such as ANXA7, Sorcin, Gelsolin showed different expressions in both gene and protein levels in Hca-F and Hca-P cell lines [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of annexin A7 gene and protein induces the apotosis and decreases the invasion, migration of the hepatocarcinoma cell line

Huang¹,

Wang²,

Du³

et al. 2014

Biomedicine & Pharmacotherapy

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inhibition of annexin A7 gene and protein induces the apotosis and decreases the invasion, migration of the hepatocarcinoma cell line

Huang¹,

Wang²,

Du³

et al. 2014

Biomedicine & Pharmacotherapy

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“…Hca-P cell, a mouse hepatocarcinoma cell line, proved to be an ideal model has been established in our laboratory [1][2][3][4][5]. Annexin A7 (ANXA7) is a ubiquitous member of the multifunctional Ca/ Phospholipid-binding annexin family.…”

Section: Introductionmentioning

confidence: 99%

Down-regulated expression of Annexin A7 induces apoptosis in mouse hepatocarcinoma cell line by the intrinsic mitochondrial pathway

Huang¹,

Du²,

Zhang³

et al. 2015

Biomedicine & Pharmacotherapy

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Ezrin as a possible diagnostic and/or prognostic biomarker in mice lymphatic metastatic hepatocellular carcinoma in vivo

et al. 2017

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Hepatocellular carcinoma (HCC) ranks in the top of cancers leading to death. Early diagnosis is the big challenge in the case of HCC. Our in vitro study showed that Ezrin expression in lymphatic metastasis hepatocellular carcinoma (LNM-HCC) was associated with the metastatic rate. Here we aim to evaluate Ezrin expression as diagnostic and/or prognostic biomarker of LNM-HCC in mice. Chinese inbred 615 mice, Hca-F and Hca-P cell lines were used in the study. Histological changes were determined by Hematoxylin and Eosin, while Ezrin expression was assessed by qRT-PCR, western blot, immunohistochemistry, and enzyme-linked immunosorbent assay. Ezrin expression in this study gives credit to our in vitro study which Ezrin expression was positively correlated with LNM-HCC and negatively with Annexin7 (A7) expression. The highest histological changes were observed in high metastatic primary/secondary tumors combined with high Ezrin expression. Ezrin and A7 are higher in total primary tumors than in total secondary tumors (P = 0.0001, P = 0.021), respectively. Ezrin expression was enhanced in Hca-P A7 down-regulated primary/secondary tumors (P = 0.004), whereas, Ezrin expression was suppressed in Hca-F A7 upregulated primary/secondary tumors. Serum ELISA indicated differential expression of Ezrin among the study groups (P ≤ 0.0001). Ezrin expression was higher in NC-Hca-F than NC-Hca-P (P ≤ 0.0001), suppressed in Hca-F A7 upregulation (P ≤ 0.0001) and in enhanced in Hca-P A7 down-regulation (P = 0.0001). In conclusion, Ezrin level may serve as a differential diagnostic and/or prognostic biomarker for high and low LNM-HCC and may be beneficial in the diagnosis of HCC disease. © 2017 BioFactors, 43(5):662-672, 2017.

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Annexin A7 gene is an important factor in the lymphatic metastasis of tumors

Cited by 19 publications

References 41 publications

Inhibition of annexin A7 gene and protein induces the apotosis and decreases the invasion, migration of the hepatocarcinoma cell line

Inhibition of annexin A7 gene and protein induces the apotosis and decreases the invasion, migration of the hepatocarcinoma cell line

Down-regulated expression of Annexin A7 induces apoptosis in mouse hepatocarcinoma cell line by the intrinsic mitochondrial pathway

Ezrin as a possible diagnostic and/or prognostic biomarker in mice lymphatic metastatic hepatocellular carcinoma in vivo

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