Annular elastolytic giant cell granuloma associated with diabetes mellitus: a case report and review of the Japanese literature

Y, Aso; Izaki, Seiichi; Teraki, Yuichi

doi:10.1111/j.1365-2230.2011.04094.x

Cited by 30 publications

(23 citation statements)

References 5 publications

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“…AEGCG can also be accompanied by systemic and dermatologic disorders such as diabetes mellitus, Hashimato's thyroiditis, stroke, temporal arteritis and vitiligo (5,8,(15)(16)(17). In our study diabetes mellitus, Hashimato's thyroiditis, hypertension, coronary artery disease, microscopic polyangiitis, Behçet's disease were found to be accompanying diseases to AEGCG.…”

Section: Discussionsupporting

confidence: 51%

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Clinicopathological Features of Annular Elastolytic Giant Cell Granuloma Patients

Erdoğan¹,

Arık²,

Acer³

et al. 2018

tdd

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Objective: Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous disease characterized by annular plaques. In this study, we aimed to describe the clinical and pathological features of the patients diagnosed with AEGCG. Methods: The demographic, clinical and pathological features of patients who diagnosed with AEGCG were recorded retrospectively. Results: Ten patients with AEGCG included in the study (nine females and one male). The mean age of the patients was 60±9.53 years. The mean duration of disease was 24.2±36.30 months. On dermatologic examination, multiple, well-demarcated, elevated borders and central atrophic erythematous annular plaques were seen in all patients. In the most of the patients (90%) lesions were on the sun-exposed regions. Six of the patients had accompanying diseases. Histopathologic examination of the punch biopsies revealed foreign body type multinucleated giant cells and lymphocytic cell infiltration in the dermis. There were intracellular elastic fiber fragments as sign of elastophagocytosis in the giant cells. Conclusion: AEGCG is a rare granulomatous disease which can accompany various diseases. There is debate on the terminology, classification and pathogenesis. Further studies are required to elucidate the unknowns.Amaç: Anüler elastolitik dev hücreli granülom (AEDHG), anüler plaklar ile karakterize, nadir granülomatöz bir hastalıktır. Bu çalışmada AEDHG tanısı konulan hastaların klinik ve patolojik özelliklerini tanımlamayı amaçladık. Yöntemler: AEDHG tanısı konulan hastaların demografik, klinik ve patolojik özellikleri retrospektif olarak kaydedildi. Bulgular: Çalışmaya AEDHG tanısı konulan 10 hasta dahil edildi (9 kadın, 1 erkek). Hastaların yaş ortalaması 60±9,53 yıldı. Ortalama hastalık süresi 24,2±36,30 aydı. Dermatolojik muayenede tüm hastalarda multipl, iyi sınırlı, sınırları kabarık ve ortası atrofik, eritemli anüler plaklar vardı. Hastaların çoğunda (%90) lezyonlar güneş gören bölgelerdeydi. Hastaların 6'sında eşlik eden hastalık mevcuttu. Punch biyopsilerin histopatolojik incelemesinde dermiste yabancı cisim tipi multinükleer dev hücreler ve lenfositik hücre infiltrasyonu görüldü. Dev hücrelerde elastofagositozun işareti olan intraselüler elastik lif parçaları vardı. Sonuç: AEGCG çeşitli hastalıklara eşlik edebilen, nadir granülomatöz bir hastalıktır. Terminoloji, sınıflandırma ve patogenezinde tartışma vardır. Bilinmeyenleri açıklığa kavuşturmak için daha ileri çalışmalara ihtiyaç vardır. Anahtar kelimeler: Anüler elastolitik dev hücreli granülom, elastofagositoz, granülomatöz hastalıklar, elastoliz, dev hücre, granüloma anülare Öz

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Section: Discussionsupporting

confidence: 51%

“…In our study diabetes mellitus, Hashimato's thyroiditis, hypertension, coronary artery disease, microscopic polyangiitis, Behçet's disease were found to be accompanying diseases to AEGCG. Aso et al (15) noticed that nearly 37% of Japanese AEGCG patients were found to have diabetes mellitus. This ratio was 20% in our study.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Features of Annular Elastolytic Giant Cell Granuloma Patients

Erdoğan¹,

Arık²,

Acer³

et al. 2018

tdd

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“…A recent Japanese report demonstrated the possible role of DM in the structural damage of the elastic fibers. This study indicated that 37% of Japanese patients with AEGCG who were evaluated for this metabolic disease were found to have definitive or latent DM [10]. …”

Section: Discussionmentioning

confidence: 99%

Hybrid Clinical and Histopathological Pattern in Annular Lesions: An Overlap between Annular Elastolytic Giant Cell Granuloma and Granuloma Annulare?

Oliveira

Silveira

Machado

et al. 2012

Case Reports in Dermatological Medicine

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Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of unclear pathogenesis which belongs to the group of disorders in the skin and elastic fibers with similar clinical features of granuloma annulare (GA). This case report is intended to describe a rare hybrid pattern in histopathology demonstrating coexistence of AEGCG and GA. An endocrine disease, such as diabetes mellitus (DM), could contribute to the coexistence of both lesions, and this possibility must be included in the medical investigation.

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“…13,48 This higher incidence may be explained by the damage of elastic fibers caused by the hyperglycemia, contributing to triggering the immune response. 25,48 The percentage of patients with diabetes is even higher among patients with the necrobiotic variant of AG. 13 For this reason, DM should be ruled out in patients diagnosed with EAGCG.…”

Section: Systemic Associationsmentioning

confidence: 99%

Elastolytic Actinic Giant Cell Granuloma

Gutiérrez‐González

Pereiro

Toribio

2015

Dermatologic Clinics

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Annular elastolytic giant cell granuloma associated with diabetes mellitus: a case report and review of the Japanese literature

Cited by 30 publications

References 5 publications

Clinicopathological Features of Annular Elastolytic Giant Cell Granuloma Patients

Clinicopathological Features of Annular Elastolytic Giant Cell Granuloma Patients

Hybrid Clinical and Histopathological Pattern in Annular Lesions: An Overlap between Annular Elastolytic Giant Cell Granuloma and Granuloma Annulare?

Elastolytic Actinic Giant Cell Granuloma

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