Anodized anisotropic titanium surfaces for enhanced guidance of gingival fibroblasts

Gulati, Karan; Moon, Hojin; Kumar, Pradeep; Han, Pingping; Ivanovski, Sašo

doi:10.1016/j.msec.2020.110860

Cited by 72 publications

(91 citation statements)

References 58 publications

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“…It is worth noting that the nanopores on the Zr wire are aligned in the direction of the underlying microfeatures of the substrate. Our group has shown that aligned TiO 2 nanopores on Ti can be used to mechanically stimulate cells [ 44 , 45 ]. Briefly, the activity of primary gingival fibroblasts and osteoblasts on aligned TiO 2 nanopores was enhanced and the cells aligned parallel to the nanopores, indicating a strong mechanotransduction effect [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…Further, such controlled dual micro–nanostructures on Zr implants have the potential to augment cell activity and local therapy. Previous studies suggest that such aligned dual micro–nanostructures can mechanically stimulate cells [ 44 ]. Therefore, future studies will focus on the evaluation of soft- and hard-tissue integration on the surface of nano-engineered Zr implants, with the current study providing important data that bridges the gap to clinical translation by evaluating clinically relevant implant surfaces.…”

Section: Resultsmentioning

confidence: 99%

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Towards Clinical Translation: Optimized Fabrication of Controlled Nanostructures on Implant-Relevant Curved Zirconium Surfaces

2021

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Anodization enables fabrication of controlled nanotopographies on Ti implants to offer tailorable bioactivity and local therapy. However, anodization of Zr implants to fabricate ZrO2 nanostructures remains underexplored and are limited to the modification of easy-to-manage flat Zr foils, which do not represent the shape of clinically used implants. In this pioneering study, we report extensive optimization of various nanostructures on implant-relevant micro-rough Zr curved surfaces, bringing this technology closer to clinical translation. Further, we explore the use of sonication to remove the top nanoporous layer to reveal the underlying nanotubes. Nano-engineered Zr surfaces can be applied towards enhancing the bioactivity and therapeutic potential of conventional Zr-based implants.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Towards Clinical Translation: Optimized Fabrication of Controlled Nanostructures on Implant-Relevant Curved Zirconium Surfaces

2021

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“…Para esta condição de anodização obteve-se nanotubos em formato ovalado e comprimento significativo recobrindo toda a superfície da amostra de maneira homogênea e regular. Sendo estes resultados próximos ao verificados por Allam, 2008 para o tântalo CP com tensão de 20V (Gulati et al, 2020). Figura 1.…”

Section: Resultsunclassified

Avaliação da biocompatibilidade do polímero PCL recobrindo a liga Ti-30Ta

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Silva

Ranieri

et al. 2020

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Nos últimos anos, diversas pesquisas têm sido realizadas buscando o desenvolvimento de materiais para aplicações biomédicas. E, um dos objetivos desses estudos, é otimizar o comportamento da interface material/meio biológico. Dentre os materiais mais utilizados, estão o titânio e suas ligas devido às suas propriedades como resistência à corrosão e biocompatibilidade. Estudos constataram que o comportamento celular pode ser influenciado por alterações na morfologia das superfícies. Dessa maneira, o objetivo deste estudo foi associar a deposição de fibras poliméricas de PCL com o crescimento de nanotubos de TiO2 na superfície da liga Ti-30Ta para aplicações biomédicas. O processo de eletrofiação foi usado para a produção de nanofibras de polímero com 200 nm, devido em grande parte, ao aumento do interesse em propriedades e tecnologias em nanoescala. O uso de polímeros biocompatíveis para a viabilidade do crescimento celular é uma alternativa promissora para melhorar a osseointegração. Técnicas de caracterização como microscopia eletrônica de varredura (MEV-FEG) foi usado para investigar a superfície das amostras. Também foram utilizadas células-tronco adultas derivadas de tecido adiposo humano (ADSC) para estudar a resposta celular desses biomateriais. A viabilidade celular foi determinada pelo ensaio Cell Titer-Blue após 1 e 7 dias. Os resultados indicaram que as alterações na nanoarquitetura das características morfológicas das nanoestruturas na micro-topografia, podem ser promissoras no campo biomédico devido à modulação da resposta celular.

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“…It appears to apply to substrates in complicated geometry which can be FIGURE 3 | Schematic representation of the nano-engineered titanium abutment with aligned TiO 2 nanopores/nanotubes toward augmented fibroblast attachment and aligning. Time-dependent attachment and spreading of fibroblasts on (A) conventional abutment and (B) electrochemically anodized abutment with aligned nanopores, (C) the proposed application of aligned nanopores toward augmenting the adhesion and alignment of fibroblasts at the transmucosal abutment-mucosa interface (yellow circle) (Gulati et al, 2020).…”

Section: Sol-gel Techniquementioning

confidence: 99%

A Brief Review on the Evolution of Metallic Dental Implants: History, Design, and Application

et al. 2021

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In recent years, significant advances in the field of medical materials have begun to emerge, especially in nanotechnology. The modern area of nanostructured implants possesses wide applications in various medical implants including their dental use. Nano-surface functions present substantial resolutions to medical obstacles through improved biomaterial proficiency, innovative dental-implant designs, and surface design procedures, such as nanoscale adhesive surfaces, bio-chemical anodization, and surface modification technique. This work covers dental implant history, nanotechnological advances, and its development that includes a description, basic properties, and the related results of composites and surface morphology, and the different types of nanomaterials used in dental implants. Significant attempts have been made over the last few decades to strengthen osteointegration and prevent bacterial attachment to the implant surfaces. The micro and nano-topography of the hierarchical surface orchestrate the biological reactions of implants and may solve the problems associated with implant-tissue issues. This research investigates the implant articles from 1964 to 2021, which offers a brief description of the nanostructured biomaterials to enhance dental implants’ performance and may open new frontiers in the advancement of implant technology.

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Anodized anisotropic titanium surfaces for enhanced guidance of gingival fibroblasts

Cited by 72 publications

References 58 publications

Towards Clinical Translation: Optimized Fabrication of Controlled Nanostructures on Implant-Relevant Curved Zirconium Surfaces

Towards Clinical Translation: Optimized Fabrication of Controlled Nanostructures on Implant-Relevant Curved Zirconium Surfaces

Avaliação da biocompatibilidade do polímero PCL recobrindo a liga Ti-30Ta

A Brief Review on the Evolution of Metallic Dental Implants: History, Design, and Application

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