Anomalies d’expression du complexe récepteur T de l’antigène/CD3 et déficits immunitaires

Deist, Françoise Le; Basile, Geneviève de Saint; Rieux-Laucat, Frédéric; Hivroz, Claire; Fischer, Alain

doi:10.1051/medsci/2007232161

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Igsf4 Localizes At the C-smac In The Immunological Synapse1

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2011

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“…IGSF4 predominantly colocalized with CD3, a key molecule of the c-SMAC, and was clearly distinguishable from LFA-1, a peripheral SMAC molecule. On the basis of these observations, we considered constituting the TCR complex, initiate a series of intracellular signaling cascades (Lin and Weiss, 2001;Le Deist et al, 2007). Surface antigens such as CD2, CD4, or CD8 and CD5, which are physically associated with the TCR complex (Beyers et al, 1992), are required for efficient signal transduction (Horejsí et al, 2004).…”

Section: Igsf4 Localizes At the C-smac In The Immunological Synapsementioning

confidence: 99%