Anomalous relation between axial length and retinal thickness in amblyopic children

Kok, Pauline H. B.; Kinkelder, Roy de; Braaksma-Besselink, Yvette; Kalkman, Jeroen; Prick, Liesbeth; Sminia, Marije L.; Mourits, Maarten P.; Verbraak, Frank D.

doi:10.1016/j.jaapos.2013.09.005

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…This was in disagreement with Araki et al; 52 they reported a significant correlation between the AL and CMT changes, which might be owing to the relatively small sample size (21 subjects with less difference in the mean SE among the study subjects). By contrast, Kok et al 53 concluded consistent results with our findings; they did not find an abnormal relation between the AL and CMT in amblyopic eyes. We did not find a significant relationship between refractive errors and the macular thickness or macular volume.…”

Section: Discussionsupporting

confidence: 83%

Changes in macular parameters in different types of amblyopia: optical coherence tomography study

Kasem¹,

Badawi²

2017

OPTH

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PurposeThe purposes of this study were to investigate the changes in macular parameters (thickness, volume) and peripapillary retinal nerve fiber layer (RNFL) thickness (RNFLT) in different cases of amblyopia versus the normal fellow eyes using optical coherence tomography (OCT) and to estimate the relationship of OCT changes with various defined patients’ parameters.DesignThis is a prospective, observational, cross-sectional case series.MethodsThe method involved measuring the peripapillary RNFLT, macular thickness, and macular volume via spectral domain (OCT) in different types of amblyopia and comparing with the other fellow eyes. This study was conducted at the Mansoura Ophthalmic Center.ResultsA total of 64 patients with different types of amblyopia were included. The mean central macular thickness (CMT) was 196.2±50.03 µm in the amblyopic eyes versus 167±12.76 µm in the fellow eyes (P=0.000), the mean average macular thickness was 265.80±12.77 µm in the amblyopic eyes versus 259.10±3.09 µm in the fellow eyes (P=0.000), the mean macular volume was 7.59±0.32 mm3 in the amblyopic eyes versus 7.34±0.071 mm3 in the fellow eyes (P=0.002), and the mean global RNFLT was 97.00±11.60 µm in the amblyopic eyes versus 78.50±13.05 µm in the fellow eyes (P=0.029). There was a discrepancy between the different amblyopic types. Age and the axial length were the only independent variables that statistically significantly correlated with the CMT.ConclusionThe unilateral amblyopic eyes were prone to have a higher CMT and thicker global RNFL compared to those of the sound fellow eyes. Retinal variations between different types of the amblyopia differ from one type to another. The age could be considered as a predictor of the disease worsening and treatment prognosis. Further studies are required to emphasize these results.

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Section: Discussionsupporting

confidence: 83%

Changes in macular parameters in different types of amblyopia: optical coherence tomography study

Kasem¹,

Badawi²

2017

OPTH

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“…We only pooled the data of persistent amblyopia, which can ensure the evaluation results were more comparable. Of the 28 enrolled publications, 8 studies compared the amblyopic eyes with those of normal control subjects (14, 26–30, 34, 35), and 2 studies compared anisometropic amblyopic patients with anisometropic nonamblyopic subjects (8, 17). These studies were performed in 16 countries and districts.…”

Section: Resultsmentioning

confidence: 99%

“…The results do not indicate that those outcome measures differ between strabismic and anisometropic amblyopia. The majority of previous studies have been limited by relatively small sample sizes, and few have healthy control subjects (14, 26–30, 34, 35). Because of insufficient statistical power in each study, our analysis containing a large number of patients increased the power to provide more convincing assessments.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, after time-domain OCT, newer spectral-domain OCT (SD-OCT) appeared with higher resolution. Numerous articles using OCT technology have been published in the recent years in which retinal nerve fiber layer (RNFL) thickness and macular structure have been evaluated in amblyopes (8, 10–36). However, these studies produced discordant results.…”

Section: Introductionmentioning

confidence: 99%

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Meta-Analysis of Retinal Changes in Unilateral Amblyopia using Optical Coherence Tomography

2015

European Journal of Ophthalmology

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“…Kok et al [ 31 ] observed that there is a relationship between the axial lengths and the pericentral retinal thickness in both amblyopic and their fellow eyes. In all participants or age groups, our findings are consistent with theirs ( R =.692, P <.0001; R =.883, P <.0001 in all participants, respectively).…”

Section: Discussionmentioning

confidence: 99%

The Assessment of Anterior and Posterior Ocular Structures in Hyperopic Anisometropic Amblyopia

Zararsız

2015

Med Sci Monit

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BackgroundThe aim of this study was to examine the relationship or differences in ocular structures of amblyopic eyes compared to fellow eyes in children and young adults with hyperopic anisometropic amblyopia.Material/MethodsHyperopic participants with anisometropic amblyopia, defined as the presence of best-corrected visual acuity differences of at least 2 Snellen lines and 1.5 diopters between amblyopic and fellow eyes, were studied. Using the IOL Master, Pentacam Scheimpflug imaging and Spectralis optical coherence tomography, the axial length, corneal curvature, and anterior chamber depth (ACD), as well as the thickness of the cornea, peripapillary retinal nerve fiber layer (RNFL), and macula, were compared between children and young adults and between their amblyopic and fellow eyes.ResultsIn 53 participants with hyperopic anisometropic amblyopia, there were significant differences in the anterior corneal curvature, ACD and axial length between the amblyopic and fellow eyes of all the patients. The mean central macular thickness in the amblyopic eyes was significantly thicker (P=.001) in the group aged 5 to 12 years; however, this was not the case in the group aged 13 to 42 years. There was no significant difference in average RNFL thickness in either group.ConclusionsWe found significantly greater mean central macular thickness in anisometropic amblyopic eyes among participants aged 5 to 12 years, but not among those who were older. Similarly, the interocular differences in axial length parameters seemed to be related to the central macular thickness differences between the amblyopic and fellow eyes in the younger group.

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Anomalous relation between axial length and retinal thickness in amblyopic children

Cited by 8 publications

References 19 publications

Changes in macular parameters in different types of amblyopia: optical coherence tomography study

Changes in macular parameters in different types of amblyopia: optical coherence tomography study

Meta-Analysis of Retinal Changes in Unilateral Amblyopia using Optical Coherence Tomography

The Assessment of Anterior and Posterior Ocular Structures in Hyperopic Anisometropic Amblyopia

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