2006
DOI: 10.1007/s00520-006-0097-7
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Anorexia–Cachexia syndrome in cancer: implications of the ubiquitin–proteasome pathway

Abstract: The ubiquitin-proteasome system is the most important pathway of protein degradation. As a regulatory system governing protein half-life, it is involved in the regulation of the cell cycle, signal transmission, immune system response, apoptosis, and oncogenesis. Knowledge of the molecular pathways involved in the induction of cancer-associated cachexia will favor a more rational approach to its treatment as well as possible quality of life and survival benefit for the patient.

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Cited by 30 publications
(26 citation statements)
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“…The ubiquitin proteasome pathway is a major protein degradation pathway involved in cancer cachexia (Camps et al 2006;Lecker et al 1999). The E1, E2, and E3 ubiquitin conjugating enzymes work to polyubiquitinate proteins for degradation by the proteasome complex.…”
Section: Discussionmentioning
confidence: 99%
“…The ubiquitin proteasome pathway is a major protein degradation pathway involved in cancer cachexia (Camps et al 2006;Lecker et al 1999). The E1, E2, and E3 ubiquitin conjugating enzymes work to polyubiquitinate proteins for degradation by the proteasome complex.…”
Section: Discussionmentioning
confidence: 99%
“…Aberrant immune system activity is a crucial aspect of the chronic systemic inflammation associated with CACS and it triggers a vicious cycle leading to further tumour growth and metastases. Although the interconnections between aberrant immune system activity and CACS are multifaceted, two specific pathways appear to be prominent; the ubiquitinproteasome pathway (Camps et al, 2006) and the vitamin D axis that includes vitamin D, the polymorphic vitamin D receptor (VDR), the vitamin D-binding protein (or Gc-protein) and its derivative, Gc protein-derived Macrophage Activating Factor (GcMAF), one of the most potent stimuli of the immune system (Strohle et al, 2010;Ruggiero and Pacini, 2011). As schematically illustrated in Fig.…”
Section: Introductionmentioning
confidence: 99%
“…Anorexia-cachexia syndrome affects up to 80% of patients with advanced cancer (Harman, 2009). This syndrome results in weight loss, anorexia, tissue wasting, weakness, impaired immune function and poor physical performance (Camps, Iranzo, Bremnes & Sirera, 2006;Esper & Harb, 2005;Laviano, Meguid, Inui, Muscaritoli, & Rossi-Fannelli, 2005). This, combined with anemia (which is often present), results in limitations in physical activities and the inhibition of protein synthesis.…”
Section: Anorexia-cachexia Syndromementioning
confidence: 99%
“…When anorexia is combined with cachexia: "it acts synergistically to impact on patients' morbidity, mortality and quality of life" (Laviano et al, 2005, p.159). According to the literature, 50% of patients express abnormalities of eating behavior at the time of initial diagnosis and in those with terminally ill cancer, the incidence increases to 65% (Camps et al, 2006Laviano et al, 2005. Patients with no weight loss at the initial cancer diagnosis had better survival rates, fewer treatment complications, and a better response to Artificial hydration at the end of life 14 chemotherapy than those with weight loss (Camps et al, 2006Laviano et al , 2005 present the optimal treatment is to cure the underlying cancer.…”
Section: Anorexia-cachexia Syndromementioning
confidence: 99%
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