Anorexia in human and experimental animal models: physiological aspects related to neuropeptides

Yoshimura, Mitsuhiro; Uezono, Yasuhito; Ueta, Yoichi

doi:10.1007/s12576-015-0386-3

Cited by 14 publications

(11 citation statements)

References 132 publications

(153 reference statements)

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“…The results of our study as well as previous studies demonstrated that both central and peripheral administration of ghrelin induced Fos expression in various regions, including the hypothalamic nuclei [6, 21]. The hypothalamic nuclei are important sites that regulate feeding and energy metabolism [6, 21, 27–30]. The neurons located in the PVN, the Arc, and the LHA express GHSR [6, 21].…”

Section: Discussionsupporting

confidence: 79%

Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist

Hashimoto

Saito

et al. 2017

J Physiol Sci

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Orexin-A and -B, and ghrelin are potent orexigenic peptides. The effects of ACT462206, a novel dual orexin receptor antagonist (DORA), on ghrelin-induced feeding were examined in adult male Wistar rats. Hyperphagia induced by the intracerebroventricular (icv) administration of ghrelin was significantly suppressed for at least 2 h by pretreatment with icv administration of DORA. A marked increase was observed in the number of neurons showing Fos immunoreactivity in the paraventricular nucleus, arcuate nucleus and lateral hypothalamic area (LHA), 90 min after icv administration of ghrelin. Pretreatment with DORA significantly decreased the number of Fos-immunoreactive (IR) neurons; however, Fos immunoreactivity remained significantly increased. Double-immunostaining for Fos and orexin-A showed that many orexin-A-IR neurons in the LHA coexisted with Fos immunoreactivity after icv administration of ghrelin, but their number was reduced significantly by DORA pretreatment. These results suggest that centrally administered ghrelin may activate the orexinergic and non-orexinergic pathways responsible for the regulation of feeding.

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Section: Discussionsupporting

confidence: 79%

Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist

Hashimoto

Saito

et al. 2017

J Physiol Sci

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“…In anorexia nervosa, the suppression of appetite is because of the psychiatric need to adjust body image to unrealistic models . In fact, a part of patients suffering from anorexia nervosa may not lack appetite . In secondary anorexia, the suppression of the appetite is because of the function disruption of the neuronal pathways that regulate the physiological eating behaviour …”

Section: Anorexiamentioning

confidence: 99%

“…Anorexia nervosa is thought to be triggered by a combination of multiple biological and social factors . This condition is closely related to social pressure and media exposure and is not easy to treat …”

Section: Anorexiamentioning

confidence: 99%

Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia

Silva

Santos

Silva

et al. 2020

J cachexia sarcopenia muscle

238

191

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Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass, along with adipose tissue wasting, systemic inflammation and other metabolic abnormalities leading to functional impairment. Cancer cachexia has long been recognized as a direct cause of complications in cancer patients, reducing quality of life and worsening disease outcomes. Some related conditions, like sarcopenia (age‐related muscle wasting), anorexia (appetite loss) and asthenia (reduced muscular strength and fatigue), share some key features with cancer cachexia, such as weakness and systemic inflammation. Understanding the interplay and the differences between these conditions is critical to advance basic and translational research in this field, improving the accuracy of diagnosis and contributing to finally achieve effective therapies for affected patients.

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“…Currently, there are numerous presumptions that postulate the existence of a relationship between anxiety/AN pathogenesis and disturbances in brain peptidergic circuits (Cuesto et al 2017, Gorwood et al 2016, Yoshimura et al 2015. Despite the accumulating number of neurochemical studies, there is still insufficient evidence dealing with the influence of central peptidergic signaling on the course of anxiety and eating disorders.…”

Section: Introductionmentioning

confidence: 99%

The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa

Pałasz

Janas–Kozik

Borrow

et al. 2018

Neurochemistry International

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Due to the dynamic development of molecular neurobiology and bioinformatic methods several novel brain neuropeptides have been identified and characterized in recent years. Contemporary techniques of selective molecular detection e.g. in situ Real-Time PCR, microdiffusion and some bioinformatics strategies that base on searching for single structural features common to diverse neuropeptides such as hidden Markov model (HMM) have been successfully introduced. A convincing majority of neuropeptides have unique properties as well as a broad spectrum of physiological activity in numerous neuronal pathways including the hypothalamus and limbic system. The newly discovered but uncharacterized regulatory factors nesfatin-1, phoenixin, spexin and kisspeptin have the potential to be unique modulators of stress responses and eating behaviour. Accumulating basic studies revelaed an intriguing role of these neuropeptides in the brain pathways involved in the pathogenesis of anxiety behaviour. Nesfatin-1, phoenixin, spexin and kisspeptin may also distinctly affect the energy homeostasis and modulate food intake not only at the level of hypothalamic centres. Moreover, in patients suffered from anxiety and anorexia nervosa a significant, sex-related changes in the plasma neuropeptide levels occurred. It should be therefore taken into account that the targeted pharmacomodulation of central peptidergic signaling may be potentially helpful in the future treatment of certain neuropsychiatric and metabolic disorders. This article reviews recent evidence dealing with the hypothetical role of these new factors in the anxiety-related circuits and pathophysiology of anorexia nervosa.

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Anorexia in human and experimental animal models: physiological aspects related to neuropeptides

Cited by 14 publications

References 132 publications

Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist

Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist

Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia

The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa

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