Anorganic bone grafting

Hurley, Lloyd A.; Zeier, Francis G.; Stinchfield, Frank E.

doi:10.1016/0002-9610(60)90532-8

Cited by 10 publications

(3 citation statements)

References 12 publications

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“…Freezing, storage, and processing of such material reportedly only reduces the immune response (Burwell 1969, Brooks et al 1963, Hurley et al 1960, Ray & Holloway 1957, Musculo et al 1976, Elves 1976. 0,6 M HCl treated allografts in our series showed no appreciable local or systemic clinical evidence of immunogenicity, as also reported by other workers.…”

Section: Discussionmentioning

confidence: 99%

“…Many sophisticated methods devised since that of Inclan (1942) are impracticable in economically under-developed countries because of perpetual power failures and lack of sophisticated facilities. Besides, even the best preserved bone (deepfrozen or lyophilised) has varying degrees of antigenicity (Burwell 1969, Brooks et al 1963, Hurley et al 1960, Ray & Holloway 1957, Musculo et al 1976, Elves 1976, Friedlander et al 1976.…”

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confidence: 99%

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Osteoinductivity of Partially Decalcified Alloimplants in Healing of Large Osteoperiosteal Defects

Gupta

Tuli

1982

Acta Orthopaedica Scandinavica

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Osteoinductivity of Partially Decalcified Alloimplants in Healing of Large Osteoperiosteal Defects

Gupta

Tuli

1982

Acta Orthopaedica Scandinavica

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“…In their experimental studies Basset & Creighton (1962) and Karges et al (1963) arrived at the same result as Bauer-Aided by a grant from the Danish Science Foundation. meister, and favourable results were obtained by Hurley et al (1960) and Anderson et al (1963) in large clinical materials.…”

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confidence: 95%

Kiel Bone in the Treatment of Pseudarthrosis: An Experimental Study

Baadsgaard¹

1969

Acta Orthopaedica Scandinavica

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Bridging large bone defects with a xenograft composited with autologous bone marrow

Gupta

Khanna

Tuli

1982

International Orthopaedics

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We have investigated the role of defatted, decalcified xenogenic bone implants composited by impregnation with fresh autologous marrow in bridging large cortical defects. Diaphyseal cortical implants were obtained from orthopaedic operations on humans and from guinea pigs and prepared by treatment with acetone, 0.6 M HCl and ethanol. The composited graft was used to bridge a 3 cm defect in the diaphysis of the ulna of rabbits. Periodic investigations were made clinically, radiographically and histologically and by tetracycline, fluorescence studies up to 20 weeks. Abundant new bone formation was observed in 85.7% of composited human xeno-autografts and in 83.3% of composited guinea pig xeno-autografts. New bone formation was seen in 13.3% of noncomposited xeno-implants. No appreciable antigenicity was observed either clinically or histologically in the grafts. The high degree of success obtained justifies further studies on implants composited by fresh autologous marrow and offers hope for the enhancement of new bone formation clinically, particularly in reconstructive operations for significant skeletal defects. We feel that the osteo-inductive potential of autologous marrow was responsible for the healing of the defects aided by the better internal milieu provided by defatted decalcified xeno implant.

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Anorganic bone grafting

Cited by 10 publications

References 12 publications

Osteoinductivity of Partially Decalcified Alloimplants in Healing of Large Osteoperiosteal Defects

Osteoinductivity of Partially Decalcified Alloimplants in Healing of Large Osteoperiosteal Defects

Kiel Bone in the Treatment of Pseudarthrosis: An Experimental Study

Bridging large bone defects with a xenograft composited with autologous bone marrow

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