Ansiedade, depressão e qualidade de vida em pacientes com glomerulonefrite familiar ou doença renal policística autossômica dominante

The effect of disease severity markers on quality of life in autosomal dominant polycystic kidney disease: a systematic review, meta-analysis and meta-regression

“…From a total of 373 unique articles identified by our systematic search, 11 studies matched our inclusion criteria [13, 15, 16, 34–41]. Figure 1 shows the PRISMA flow diagram with specified reasons for exclusion.…”

“…There was excellent agreement between the two reviewers on study selection (Cohen’s Kappa 0.89). We found only two studies that investigated QoL in patients with ADPKD on dialysis ( n  = 108 and n  = 5 respectively), which prevented a reliable meta-analysis in this subgroup [15, 34]. We contacted eight authors for additional information that was not published in the original articles and received relevant data from six of them [15, 34–36, 38, 39].…”

“…We found only two studies that investigated QoL in patients with ADPKD on dialysis ( n  = 108 and n  = 5 respectively), which prevented a reliable meta-analysis in this subgroup [15, 34]. We contacted eight authors for additional information that was not published in the original articles and received relevant data from six of them [15, 34–36, 38, 39]. Four studies included a mixed population of patients with isolated polycystic liver disease (ADPLD) and polycystic liver disease as extrarenal manifestation of ADPKD [35, 36, 39, 40].…”

“…Table 1 describes the characteristics of the nine studies included in meta-analysis [13, 15, 16, 34–39]. The majority were longitudinal interventional studies ( n  = 7), including three randomized controlled trials.…”

“…Volumes are presented on a logarithmic scale. Barros et al, [34]; Hogan et al, [35]; Keimpema et al, [36]; Lee et al, [37]; Miskulin et al, [13] subgroup eGFR 20–44*; Miskulin et al, [13] subgroup eGFR 45–60; Miskulin et al, [13] subgroup eGFR ≥60; Rizk et al, [16]; Simms et al, [38] subgroup eGFR <30; Simms et al, [38] subgroup eGFR 30–60; Simms et al, [38] subgroup eGFR >60; Suwabe et al, [15]; Temmerman et al, [39]. *No kidney and liver imaging in this subgroup, not included in figures b - d …”