Antagonistic effect of d-myo-inositol-1,2,6-trisphosphate (PP56) on neuropeptide Y-induced vasoconstriction in the feline dental pulp

Differential expression of neuropeptide Y Y1 receptors during pulpal inflammation

“…2005, 2007). Y1R is the target receptor for NPY, a neuropeptide that is mainly released from sympathetic nerve terminals and a potent vasoconstrictor in the dental pulp (Kim et al. 1996).…”

“…NPY has several different functions such as vasoconstriction, angiogenesis, modulation of inflammation and pain (Wahlestedt et al. 1990, Kim et al. 1996, Bedoui et al.…”

Quantification of neuropeptides (calcitonin gene‐related peptide, substance P, neurokinin A, neuropeptide Y and vasoactive intestinal polypeptide) expressed in healthy and inflamed human dental pulp

“…It has been demonstrated that variations in adrenergic activity could induce changes in dentinogenesis through blood vascular changes or modulation of odontoblast metabolism (Avery et al 1980, Rodd & Boissonade 2002. Although sympathetic fibres do not reach the odontoblastic layer, during the inflammatory process, NPY expression increases as it plays an important role in sympathetic vasoregulation, enhancing noradrenaline-evoked vasoconstriction at the postsynaptic level as a response of intense vasodilation produced by neuropeptides released from sensory fibres (Kim et al 1996).…”

“…NPY was found to be a potent inhibitor of vasodilation induced by acetylcholine and SP, playing an important role in sympathetic vasoregulation (Fallgren et al 1989). Administration of NPY to dental pulp reduces pulpal blood flow via vasoconstriction similar in magnitude to that produced by electrical stimulation of the sympathetic fibres that innervate the pulp (Kim et al 1996).…”

An overview of the dental pulp: its functions and responses to injury

“…38,[59][60][61][62] Pulp blood flow in anaesthetized animals of several species is under the influence of local nerve impulses unrelated to systemic haemodynamics. 63 Perivascular sympathetic nerve fibres liberate noradrenaline and possible neuropeptide Y causing a reduction of pulp blood flow, [64][65][66][67] whereas intradental sensory nerves liberate neuropeptides causing an increase in pulp blood flow. 50,[68][69][70][71] Reflex excitation of the sympathetic nervous system causes pulp vasoconstriction and a reduction in pulp blood flow.…”