Antenna system applicable to microwave non-invasive hyperthermia lipolysis

Park, Sangbok; Hwang, Joosung; Kwon, Youngwoo; Cheon, Changyul

doi:10.1049/el.2012.2010

Cited by 9 publications

(9 citation statements)

References 3 publications

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“…Nevertheless, the low energy associated with NIR light, the weak PS activation ability and obvious side effects to normal tissues of X-ray, as well as the unsatisfactory energy transfer from internal light to PS remain challenging tasks. Recently, several new PDT excitation sources, including microwaves 130 , radio-waves 131 , ultrasound 132 , electrical fields (EF) 133 , and magnetic fields (MF) 134 , have emerged and made some progress. Microwave irradiation can cause local hyperthermia and increase the blood supply to the tumor.…”

Section: Light Sourcementioning

confidence: 99%

Recent advances in innovative strategies for enhanced cancer photodynamic therapy

et al. 2021

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Photodynamic therapy (PDT), a non-invasive therapeutic modality, has received increasing attention owing to its high selectivity and limited side effects. Although significant clinical research progress has been made in PDT, the breadth and depth of its clinical application have not been fully realized due to the limitations such as inadequate light penetration depth, non-targeting photosensitizers (PSs), and tumor hypoxia. Consequently, numerous investigations put their emphasis on innovative strategies to overcome the aforementioned limitations and enhance the therapeutic effect of PDT. Herein, up-to-date advances in these innovative methods for PDT are summarized by introducing the design of PS systems, their working mechanisms and application examples. In addition, current challenges of these innovative strategies for clinical application, and future perspectives on further improvement of PDT are also discussed.

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Section: Light Sourcementioning

confidence: 99%

Recent advances in innovative strategies for enhanced cancer photodynamic therapy

et al. 2021

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“…The NIR light can penetrate into the tissues when exposed to an alternating current(for generating a magnetic field) than when not exposed to an alternating current. The resultant deeper penetration shows an effective cellular uptake and obvious production of 1 O 2 in vitro . Tedesco and co‐workers found an increase in diffusional flux for Foscan when coupled with a magnetic nanoemulsion, which improved in vivo drug penetration in the skin layers.They found that a higher penetration of photosensitizers in skin layer due to the presence of MF resulted in accumulation of the drug (Foscan) in the skin tumor .…”

Section: Magnetic Fields (Mf)mentioning

confidence: 99%

Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors

2019

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The viable use of photodynamic therapy (PDT) in cancer therapy has never been fully realized because of its undesirable effects on healthy tissues. Herein we summarize some physicochemical factors that can make PDT a more viable and effective option to provide future oncological patients with better‐quality treatment options. These physicochemical factors include light sources, photosensitizer (PS) carriers, microwaves, electric fields, magnetic fields, and ultrasound. This Review is meant to provide current information pertaining to PDT use, including a discussion of in vitro and in vivo studies. Emphasis is placed on the physicochemical factors and their potential benefits in overcoming the difficulty in transitioning PDT into the medical field. Many advanced techniques, such as employing X‐rays as a light source, using nanoparticle‐loaded stem cells and bacteriophage bio‐nanowires as a photosensitizer carrier, as well as integration with immunotherapy, are among the future directions.

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“…However, one of the urgent problems of aesthetic surgery, which is to develop an effective and safe method of removing unwanted fat, remains unresolved. There are many contemporary wave‐based methods of fat cell lipolysis and liposuction, such as ultrasonic , radiofrequency and laser technologies. The wave method is associated with radiation in a certain range of wavelengths (frequencies), which is effectively absorbed by the tissue, that is, optical, microwave or ultrasonic radiation.…”

Section: Introductionmentioning

confidence: 99%

Skin and subcutaneous fat morphology alterations under the LED or laser treatment in rats in vivo

Yanina

Navolokin

Bucharskaya

et al. 2019

Journal of Biophotonics

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The main objective of this work is to quantify the impact of photodynamic/photothermal treatment by using visible LED and NIR laser irradiation through the skin of subcutaneous fat in vivo followed up by tissue sampling and histology. The optical method may provide reduction of regional or site‐specific accumulations of abdominal or subcutaneous adipose tissue precisely and least‐invasively by inducing cell apoptosis and controlled necrosis of fat tissue. As photodynamic/photothermal adipose tissue sensitizers Brilliant Green (BG) or Indocyanine Green (ICG) dyes were injected subcutaneously in rats. The CW LED device (625 nm) or CW diode laser (808 nm) were used as light sources, respectively. Biopsies of skin together with subcutaneous tissues were taken for histology. The combined action BG‐staining and LED‐irradiation (BG + LED) or ICG‐staining and NIR‐laser irradiation (ICG + NIR) causes pronounced signs of damage of adipose tissue characterized by a strong stretching, thinning, folding and undulating of cell membranes and appearance of necrotic areas. As a posttreatment after 14 days only connective tissue was observed at the site of necrotic areas. The data obtained are important for safe light treatment of site‐specific fat accumulations, including cellulite. This work provides a basis for the development of fat lipolysis technologies and to move them to clinical applications. Schematics of animal experiment.

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Antenna system applicable to microwave non-invasive hyperthermia lipolysis

Cited by 9 publications

References 3 publications

Recent advances in innovative strategies for enhanced cancer photodynamic therapy

Recent advances in innovative strategies for enhanced cancer photodynamic therapy

Enhancement of Photodynamic Cancer Therapy by Physical and Chemical Factors

Skin and subcutaneous fat morphology alterations under the LED or laser treatment in rats in vivo

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