Anterior Cervical Interbody Fusion Using Polyetheretherketone Cage Filled With Autologous and Synthetic Bone Graft Substrates for Cervical Spondylosis: Comparative Analysis Between PolyBone&lt;sup&gt;®&lt;/sup&gt; and Iliac Bone

Park, Jin Hoon; Roh, Sung Woo

doi:10.2176/nmc.53.85

Cited by 16 publications

(18 citation statements)

References 23 publications

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“…β-TCP has been a used widely graft material in dental, cranial, and spinal surgery [ 15 , 16 , 17 , 18 , 19 , 20 ]. In addition, cement type bone graft material, which is composed of β-TCP and polyphosphate, has been used to induce bone regeneration after cranial or spinal surgery [ 12 , 13 , 14 ]. It has also been used as a scaffold because of its high porosity that provides sufficient spaces for newly formed bone to grow after spinal surgery.…”

Section: Discussionmentioning

confidence: 99%

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Bone cement grafting increases implant primary stability in circumferential cortical bone defects

Shin

Kye

Chang

et al. 2015

J Periodontal Implant Sci

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PurposeImplant beds with an insufficient amount of cortical bone or a loss of cortical bone can result in the initial instability of a dental implant. Thus, the objective of this study was to evaluate the effect of bone cement grafting on implant initial stability in areas with insufficient cortical bone.MethodsTwo different circumferential defect depths (2.5 mm and 5 mm) and a control (no defect) were prepared in six bovine rib bones. Fourteen implants of the same type and size (4 mm×10 mm) were placed in each group. The thickness of the cortical bone was measured for each defect. After the implant stability quotient (ISQ) values were measured three times in four different directions, bone cement was grafted to increase the primary stability of the otherwise unstable implant. After grafting, the ISQ values were measured again.ResultsAs defect depth increased, the ISQ value decreased. In the controls, the ISQ value was 85.45±3.36 (mean±standard deviation). In circumferential 2.5-mm and 5-mm defect groups, the ISQ values were 69.42±7.06 and 57.43±6.87, respectively, before grafting. These three values were significantly different (P<0.001). After grafting the bone cement, the ISQ values significantly increased to 73.72±8.00 and 67.88±10.09 in the 2.5-mm and 5.0-mm defect groups, respectively (P<0.05 and P<0.001). The ISQ value increased to more than double that before grafting in the circumferential 5-mm defect group. The ISQ values did not significantly differ when measured in any of the four directions.ConclusionsThe use of bone cement remarkably increased the stability of the implant that otherwise had an insufficient level of stability at placement, which was caused by insufficient cortical bone volume.Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

“…After approximately seven weeks, the commencement of absorption can be identified. Bone cement is commonly employed in orthopedic surgery and neurosurgery [ 12 , 13 , 14 ]. The ideal hardening time of bone cement is less than 5 minutes, and this reaction is not an exothermic reaction.…”

Section: Introductionmentioning

confidence: 99%

Bone cement grafting increases implant primary stability in circumferential cortical bone defects

Shin

Kye

Chang

et al. 2015

J Periodontal Implant Sci

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“…Various materials have been proposed as interbody grafts for ACDF surgery to avoid the problems associated with autologous bone grafts12204345). The characteristics of an ideal graft material include immediate structural biomechanical stability and the capacity for subsequent osteogenesis 152835). Titanium, carbon fiber, and PEEK are the most commonly used materials for cervical interbody cages.…”

Section: Discussionmentioning

confidence: 99%

Surgical Outcomes of Anterior Cervical Fusion Using Deminaralized Bone Matrix as Stand-Alone Graft Material: Single Arm, Pilot Study

et al. 2016

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ObjectiveTo investigate the safety and efficacy of demineralized bone matrix (DBM) as a bone graft substitute for anterior cervical discectomy and fusion (ACDF) surgery.MethodsTwenty consecutive patients treated with ACDF using stand-alone polyestheretherketone (PEEK) cages (Zero-P) with DBM(CGDBM100) were prospectively evaluated with a minimum of 6 months of follow-up. Radiologic efficacy was evaluated with a 6-point scoring method for osseous fusion using plain radiograph and computed tomogrpahy scans. Clinical efficacy was evaluated using the visual analogue scale (VAS), Owestry disability index (ODI), and short-form health questionnaire-36. The safety of the bone graft substitute was assessed with vital sign monitoring and a survey measuring complications at each follow-up visit.ResultsThere were significant improvements in VAS and ODI scores at a mean 6-month follow-up. Six months after surgery, solid fusion was achieved in all patients. Mean score on the 6-point scoring system was 5.1, and bony formation was found to score at least 4 points in all patients. There was no case with implant-related complications such as cage failure or migration, and no complications associated with the use of CGDBM100.ConclusionACDF using CGDBM100 demonstrated good clinical and radiologic outcomes. The fusion rate was comparable with the published results of traditional ACDF. Therefore, the results of this study suggest that the use of a PEEK cage packed with DBM for ACDF is a safe and effective alternative to the gold standard of autologous iliac bone graft.

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“… 59 Sugawara et al 37 used cylindrical titanium cages packed with β-TCP in 57 patients and found no dislocation or material-related complications, in contrast to the study by Zagra et al 59 They reported that the fusion rate was significantly higher in the β-TCP compared with HA at 6-month (46% vs 24%) and 1-year follow-up (69% vs 49%); however, the fusion rate was similar between groups at 2-year follow-up (94% vs 90%). 37 Park and Roh 60 compared the efficacy of iliac autograft with PEEK cages filled with β-TCP. After 24 months, fusion had occurred in 22 of 24 patients treated with β-TCP and in 22 of 23 patients with iliac autograft.…”

Section: Tricalcium Phosphatementioning

confidence: 99%

Clinical Application of Ceramics in Anterior Cervical Discectomy and Fusion: A Review and Update

Zadegan

Abedi

Jazayeri

et al. 2017

Global Spine Journal

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Study Design:Narrative review.Objectives:Anterior cervical discectomy and fusion (ACDF) is a reliable procedure, commonly used for cervical degenerative disc disease. For interbody fusions, autograft was the gold standard for decades; however, limited availability and donor site morbidities have led to a constant search for new materials. Clinically, it has been shown that calcium phosphate ceramics, including hydroxyapatite (HA) and tricalcium phosphate (TCP), are effective as osteoconductive materials and bone grafts. In this review, we present the current findings regarding the use of ceramics in ACDF.Methods:A review of the relevant literature examining the clinical use of ceramics in anterior cervical discectomy and fusion procedures was conducted using PubMed, OVID and Cochrane.Result:HA, coralline HA, sandwiched HA, TCP, and biphasic calcium phosphate ceramics were used in combination with osteoinductive materials such as bone marrow aspirate and various cages composed of poly-ether-ether-ketone (PEEK), fiber carbon, and titanium. Stand-alone ceramic spacers have been associated with fracture and cracks. Metallic cages such as titanium endure the risk of subsidence and migration. PEEK cages in combination with ceramics were shown to be a suitable substitute for autograft.Conclusion:None of the discussed options has demonstrated clear superiority over others, although direct comparisons are often difficult due to discrepancies in data collection and study methodologies. Future randomized clinical trials are warranted before definitive conclusions can be drawn.

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Anterior Cervical Interbody Fusion Using Polyetheretherketone Cage Filled With Autologous and Synthetic Bone Graft Substrates for Cervical Spondylosis: Comparative Analysis Between PolyBone<sup>®</sup> and Iliac Bone

Cited by 16 publications

References 23 publications

Bone cement grafting increases implant primary stability in circumferential cortical bone defects

Bone cement grafting increases implant primary stability in circumferential cortical bone defects

Surgical Outcomes of Anterior Cervical Fusion Using Deminaralized Bone Matrix as Stand-Alone Graft Material: Single Arm, Pilot Study

Clinical Application of Ceramics in Anterior Cervical Discectomy and Fusion: A Review and Update

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