Anterior Chamber Angle and Trabecular Meshwork Measurements Made by Fourier-domain Optical Coherence Tomography in Healthy White Children

Fernández‐Vigo, José Ignacio; De‐Pablo‐Gómez‐de‐Liaño, Lucía; Fernández‐Vigo, Cristina; Arcos-Villegas, G.; Fernández-Pérez, Cristina; García‐Feijoó, Julián; Fernández‐Vigo, José Ángel

doi:10.1097/ijg.0000000000000724

Cited by 16 publications

(20 citation statements)

References 28 publications

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“…While an earlier study (Kagemann et al 2010) identified this hypo‐reflective region, shown in our study, as shadow of the TM interface, recent studies using high‐resolution ASOCT (Li et al 2017; Crowell et al 2018) confirm this to be the SC with histopathological corroboration. Fernandez‐Vigo et al (2017) also showed the anatomical variations of SC especially with age in healthy children but did not show a communication between the SC and the anterior chamber. Our finding of this communication of the SC with anterior chamber in eyes of healthy children and in some fellow eyes of PCG patients was accidental, and the study was not designed to evaluate this finding.…”

Section: Discussionmentioning

confidence: 97%

“…Embryologically, this communication could also be part of the development of the SC which originates as a radial vessel in the optic cup, another observation of Sondermann (1930). Earlier studies on AS OCT have also shown images of such a communication, though the authors did not comment on it (Asrani et al 2008; Hong et al 2013; Fernandez‐Vigo et al 2017). We confirmed this communication in multiple ultrathin (0.5 µm thick) histopathological sections (plastic embedded) which refute this direct communication to be an artefact of ASOCT that may have missed thin strands of TM.…”

Section: Discussionmentioning

confidence: 98%

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Differences in outflow channels between two eyes of unilateral primary congenital glaucoma

Gupta

Singh

Pandya

et al. 2020

Acta Ophthalmologica

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Purpose Primary congenital glaucoma (PCG) occurs in only one eye in some patients. We aimed to characterize anatomical features of the angle and Schlemm’s canal (SC) in vivo among fellow eyes of patients with unilateral primary congenital glaucoma. Methods Both eyes of 33 children with unilateral PCG and 30 healthy, age‐matched children, old enough to co‐operate were analysed using high‐resolution anterior segment spectral domain (SD) OCT. Subgroup analysis was done for the presence/absence of angle dysgenesis as defined by the presence of abnormal tissue/hyper‐reflective membrane within angle recess and/or the absence of SC. Other anatomical landmarks differentiating the fellow eyes from eyes with glaucoma were also evaluated and compared with healthy subjects. Results The presence of abnormal tissue at the angle and/or a hyper‐reflective membranous structure covering the meshwork was seen in all affected PCG eyes (100%) and in 21 (63%) unaffected fellow eyes; p = 0.001. The SC could be seen in 8 (24%) affected in comparison with 29 (88%) fellow unaffected eyes; p = 0.001. The ASOCT scans of 54 (90%) healthy eyes and 3 (9%) fellow PCG eyes revealed a direct communication of anterior portion of the SC with the anterior chamber. Among the fellow eyes, a communication of the supraciliary space with anterior chamber could be discerned in 26 eyes (79%). Conclusions Despite angle dysgenesis, outflow channels such as the uveoscleral or a direct communication of SC with the anterior chamber play a role in preventing the development of glaucoma in fellow eyes of unilateral PCG.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Differences in outflow channels between two eyes of unilateral primary congenital glaucoma

Gupta

Singh

Pandya

et al. 2020

Acta Ophthalmologica

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“…Fernandez et al examined 409 right eyes of 409 children with Fourier‐domain OCT proving Fourier‐domain OCT to be a successful non‐invasive tool for measurement of the trabecular‐iris angle and trabecular meshwork.…”

Section: Other Oct Applications/anterior Segment Octmentioning

confidence: 99%

Optical coherence tomography in paediatric clinical practice

Maccora

Sheth

Ruddle

2019

Clinical and Experimental Optometry

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Optical coherence tomography is a non-invasive ocular imaging technique that is frequently used in the diagnosis and monitoring of optic nerve or retinal disease. Advances in optical coherence tomography speed and image processing capability allow increased use of the modality in clinical practice, especially in younger children. This review outlines the challenges involved in imaging children, highlights the technological progress, the importance of acquiring normative data and, finally, focuses on the clinical applicability of optical coherence tomography in our paediatric population with various ocular conditions.

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“…AOD 500 was measured as the perpendicular distance from the trabecular meshwork at 500 lm anterior to the scleral spur, to the anterior iris surface (Fern andez-Vigo et al 2017). The length and area of the TM were also measured: TM length was measured from the hyper-reflective point closest to the scleral spur to the hyper-reflective point closest to Schwalbe's line; TM area was measured by tracing the trapezoidal shape delineated by the hyper-reflective tissue not including the surrounding hypo-reflective arc, or TM interface shadow (Wong et al 2009;Kagemann et al 2010;Fern andez-Vigo et al 2017).…”

Section: Examination Proceduresmentioning

confidence: 99%

“…To date most of these angle studies, especially the larger ones, have been performed in adult Asian populations (Usui et al 2011;Shi et al 2012;Hong et al 2013), and only a few such studies have sought to assess the angle in children (Urbak 1999;Jin et al 2016;Fern andez-Vigo et al 2017;Tandon et al 2017). This lack of literature data also means that the possible effects of several factors such as gender, age, refractive error, angle or TM measurements on the size of the anterior chamber angle and its structures have yet to be addressed.…”

Section: Introductionmentioning

confidence: 99%

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

Fernández‐Vigo

Kudsieh²,

De‐Pablo‐Gómez‐de‐Liaño

et al. 2018

Acta Ophthalmologica

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Purpose To measure the Schlemm's canal (SC) in vivo by Fourier‐domain optical coherence tomography (FD‐OCT) in a Caucasian paediatric population. Methods Participants of this cross‐sectional study were 290 healthy children. In the right eye of each child, SC cross‐sectional diameter and area measurements were made with the FD‐OCT instrument RTVue® (Optovue Inc, Fremont, CA, USA) in the nasal and temporal quadrants. These SC variables were then assessed for correlation with the factors age, gender, refractive error, anterior chamber angle and trabecular meshwork (TM) metrics. Finally, the reproducibility of the SC measurements was assessed in 30 of the participants. Results Mean participant age was 10.7 ± 3.4 years (range 3–18). SC diameters could be measured in both quadrants in 70.6% and 70.4% of subjects, respectively. Mean SC diameters were similar (p = 0.125) for the temporal and nasal quadrants: 266.7 ± 84.1 μm (range 131–509) and 273.2 ± 77.3 μm (range 124–486), respectively. Mean SC areas were also similar (p = 0.167) for the two quadrants: 9975 ± 3514 μm2 (range 4000–23 000) versus 9688 ± 3297 μm2 (range 3000–24 000). No differences were detected in SC measurements according to gender, refractive error or angle and TM measurements (R ≤ 0.116; p ≥ 0.125). The exception was age which was directly correlated with SC size (p ≤ 0.041). The reproducibility of the SC measurements was excellent (intraclass correlation coefficients ≥0.936). Conclusion FD‐OCT allows the identification of the SC in children. Our data indicate an increase in SC size produced with age.

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Anterior Chamber Angle and Trabecular Meshwork Measurements Made by Fourier-domain Optical Coherence Tomography in Healthy White Children

Abstract: FD-OCT proved useful for the noninvasive measurement of TIA and TM metrics in children. Spherical error was the main determinant of TIA.

Cited by 16 publications

References 28 publications

Differences in outflow channels between two eyes of unilateral primary congenital glaucoma

Differences in outflow channels between two eyes of unilateral primary congenital glaucoma

Optical coherence tomography in paediatric clinical practice

Schlemm's canal measured by optical coherence tomography and correlation study in a healthy Caucasian child population

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