Anterior Circulation Acute Ischemic Stroke in the Plateau of China: Risk Factors and Clinical Characteristics

Yan, Yujia; Zhang, Xiqiang; Ren, Hecheng; An, Xingwei; Fan, Wanpeng; Liang, Jingbo; Huang, Ying

doi:10.3389/fneur.2022.859616

Cited by 1 publication

(2 citation statements)

References 61 publications

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“…Baseline clinical characteristics of patients in the plateau were significantly different compared to the plain patients, with a higher prevalence of hypertension, hyperlipidemia, erythrocytosis, and alcohol abuse, and lower diabetes. The epidemiological and metabolic characteristics of patients in the plateau have been reported in detail in our previous studies (5). The incidence of ICH is higher in the plateau of China, especially the Qinghai-Tibet Plateau, compared to the more medically and economically developed southeastern China.…”

Section: Discussionmentioning

confidence: 78%

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Clinical characteristics of spontaneous intracranial basal ganglia hemorrhage and risk factors for hematoma expansion in the plateaus of China

et al. 2023

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Background and purposeThe clinical features of intracranial cerebral hemorrhage (ICH) and the risk factors for hematoma expansion (HE) have been extensively studied. However, few studies have been performed in patients who live on a plateau. The natural habituation and genetic adaptation have resulted in differences in disease characteristics. The purpose of this study was to investigate the differences and consistency of clinical and imaging characteristics of patients in the plateaus of China compared with the plains, and to analyze the risk factors for HE of intracranial hemorrhage in the plateau patients.MethodsFrom January 2020 to August 2022, we undertook a retrospective analysis of 479 patients with first-episode spontaneous intracranial basal ganglia hemorrhage in Tianjin and Xining City. The clinical and radiologic data during hospitalization were analyzed. Univariate and multivariate logistic regression analyzes were used to assess the risk factors for HE.ResultsHE occurred in 31 plateau (36.0%) and 53 plain (24.2%) ICH patients, and HE was more likely to occur in the plateau patients compared with the plain (p = 0.037). The NCCT images of plateau patients also showed heterogeneity of hematoma imaging signs, and the incidence of blend signs (23.3% vs. 11.0%, p = 0.043) and black hole signs (24.4% vs. 13.2%, p = 0.018) was significantly higher than in the plain. Baseline hematoma volume, black hole sign, island sign, blend sign, and PLT and HB level were associated with HE in the plateau. Baseline hematoma volume and the heterogeneity of hematoma imaging signs were independent predictors of HE in both the plain and plateau.ConclusionCompared with the plain, ICH patients in the plateau were more prone to HE. The patients showed the same heterogeneous signs on the NCCT images as in the plain, and also had predictive value for HE.

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Section: Discussionmentioning

confidence: 78%

“…The highland resident population is different from the general population due to natural habituation, physiological compensation, and genetic adaptation to the unique environment (low oxygen, low atmospheric pressure, low temperature, and intense ultraviolet radiation, etc.) over a long period of time, which makes them unique (5).…”

Section: Introductionmentioning

confidence: 99%