Anterior lens capsule: biomechanical properties and biomedical engineering perspectives

Huang, Dandan; Xu, Chenjia; Guo, Ruru; Ji, Jian; Liu, Wei

doi:10.1111/aos.14600

Cited by 10 publications

(8 citation statements)

References 56 publications

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“…Limbal cells are cultured and expanded in vitro using an amniotic membrane [ 50 ] or a tissue-engineered scaffold [ 51 , 52 ]. The anterior lens capsule (ALC) can be easily obtained during cataract surgery and, due to the optical transparency and widespread availability, proved to be an excellent scaffold for limbal stem cell proliferation and ocular surface restoration [ 53 , 54 ]. CLET shows fewer risks for the donor eye, avoiding the risk of running into iatrogenic LSCD, and adding the possibility to treat partial bilateral LSCD [ 55 ].…”

Section: Cell Therapiesmentioning

confidence: 99%

Corneal Epithelial Regeneration: Old and New Perspectives

Nuzzi

Giuffrida

Luccarelli

et al. 2022

IJMS

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Corneal blindness is the fifth leading cause of blindness worldwide, and therapeutic options are still often limited to corneal transplantation. The corneal epithelium has a strong barrier function, and regeneration is highly dependent on limbal stem cell proliferation and basement membrane remodeling. As a result of the lack of corneal donor tissues, regenerative medicine for corneal diseases affecting the epithelium is an area with quite advanced basic and clinical research. Surgery still plays a prominent role in the treatment of epithelial diseases; indeed, innovative surgical techniques have been developed to transplant corneal and non-corneal stem cells onto diseased corneas for epithelial regeneration applications. The main goal of applying regenerative medicine to clinical practice is to restore function by providing viable cells based on the use of a novel therapeutic approach to generate biological substitutes and improve tissue functions. Interest in corneal epithelium rehabilitation medicine is rapidly growing, given the exposure of the corneal outer layers to external insults. Here, we performed a review of basic, clinical and surgical research reports on regenerative medicine for corneal epithelial disorders, classifying therapeutic approaches according to their macro- or microscopic target, i.e., into cellular or subcellular therapies, respectively.

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Section: Cell Therapiesmentioning

confidence: 99%

Corneal Epithelial Regeneration: Old and New Perspectives

Nuzzi

Giuffrida

Luccarelli

et al. 2022

IJMS

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“…Additionally, SC and TM are also subjected to the ocular pulse generated from either cardiac pulsation in the retina and choroid or the pressure oscillations in the episcleral vessels ( 14 ). The lens capsule completely encloses the crystalline lens, with its thicker and more durable anterior capsule (toward aqueous humor) accommodating to the IOP ( 15 ), and the posterior capsule (toward vitreous cavity) facing the intravitreal pressure ( 16 ). The viscosity and elasticity properties of the capsule membrane exhibit high resistance to extrinsic mechanical strength and intrinsic deformative stress occurring in the lens shape alterations ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Biomechanical homeostasis in ocular diseases: A mini-review

Cheng

Ren

Wang

2023

Front. Public Health

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Diabetes mellitus-induced hyperglycemia is responsible for multiple pathological ocular alternations from vasculopathy to biomechanical dyshomeostasis. Biomechanical homeostasis is crucial to maintain the normal physiological condition of the eyes. Biomechanical features vary in eye tissues regarding different anatomical positions, tissue components, and cellular functions. The disturbance in biomechanical homeostasis may result in different ocular diseases. In this review, we provide a preliminary sketch of the latest evidence on the mechano-environment of the eyeball and its possible influencing factors, thereby underscoring the relationship between the dyshomeostasis of ocular biomechanics and common eye diseases (e.g., diabetic retinopathy, keratoconus, glaucoma, spaceflight-associated neuro-ocular syndrome, retinal vein occlusion and myopia, etc.). Together with the reported evidence, we further discuss and postulate the potential role of biomechanical homeostasis in ophthalmic pathology. Some latest strategies to investigate the biomechanical properties in ocular diseases help unveil the pathological changes at multiple scales, offering references for making new diagnostic and treatment strategies targeting mechanobiology.

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“…This intrinsic morphological adjustment of the lens to fulfill changing visual demands has prompted numerous studies on the mechanical properties of the lens and its suspension system, which includes the capsular bag, ciliary muscles, zonules, and choroids ( Beers and Van Der Heijde, 1994 ; Pedrigi et al, 2007 ; Weeber and van der Heijde, 2007 ; Ronci et al, 2011 ; Sharma et al, 2011 ). In particular, the role of the lens capsule in the accommodative function as well as in cataract surgery, is associated with its biomechanical properties ( Huang et al, 2021 ). The progressive change in capsular mechanical strength due to aging alters the dynamic interaction between the capsule and lens and could lead to changes in the accommodation process.…”

Section: Introductionmentioning

confidence: 99%

The lens capsule significantly affects the viscoelastic properties of the lens as quantified by optical coherence elastography

Mekonnen

Zevallos-Delgado²,

Zhang³

et al. 2023

Front. Bioeng. Biotechnol.

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The crystalline lens is a transparent, biconvex structure that has its curvature and refractive power modulated to focus light onto the retina. This intrinsic morphological adjustment of the lens to fulfill changing visual demands is achieved by the coordinated interaction between the lens and its suspension system, which includes the lens capsule. Thus, characterizing the influence of the lens capsule on the whole lens’s biomechanical properties is important for understanding the physiological process of accommodation and early diagnosis and treatment of lenticular diseases. In this study, we assessed the viscoelastic properties of the lens using phase-sensitive optical coherence elastography (PhS-OCE) coupled with acoustic radiation force (ARF) excitation. The elastic wave propagation induced by ARF excitation, which was focused on the surface of the lens, was tracked with phase-sensitive optical coherence tomography. Experiments were conducted on eight freshly excised porcine lenses before and after the capsular bag was dissected away. Results showed that the group velocity of the surface elastic wave, V, in the lens with the capsule intact (V=2.55±0.23 m/s) was significantly higher (p < 0.001) than after the capsule was removed (V=1.19±0.25 m/s). Similarly, the viscoelastic assessment using a model that utilizes the dispersion of a surface wave showed that both Young’s modulus, E, and shear viscosity coefficient, η, of the encapsulated lens (E=8.14±1.10 kPa,η=0.89±0.093 Pa∙s) were significantly higher than that of the decapsulated lens (E=3.10±0.43 kPa,η=0.28±0.021 Pa∙s). These findings, together with the geometrical change upon removal of the capsule, indicate that the capsule plays a critical role in determining the viscoelastic properties of the crystalline lens.

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Anterior lens capsule: biomechanical properties and biomedical engineering perspectives

Cited by 10 publications

References 56 publications

Corneal Epithelial Regeneration: Old and New Perspectives

Corneal Epithelial Regeneration: Old and New Perspectives

Biomechanical homeostasis in ocular diseases: A mini-review

The lens capsule significantly affects the viscoelastic properties of the lens as quantified by optical coherence elastography

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