Anterior segment changes in rabbits after experimental aqueous replacement with various amounts of different perfluorocarbon liquids

Abstract

Anterior segment damage caused by PFC liquids is a contact-dependent effect seen in the early observation period. Experimentally there was no difference between the products used or between 2 and 4 weeks' duration of the tamponade.

Clinical findings on the use of long-term heavy tamponades (semifluorinated alkanes and their oligomers) in complicated retinal detachment surgery

“…In most cases concerns were raised because of poor biological tolerance or severe inflammation, as with fluorosilicone or in eyes filled with liquid perfluorocarbons for an extended period [1,2,3,4,10,11,12].…”

Heavier-than-Water Silicone Oil Mixture as a Long-Term Tamponade Agent: A Pilot Study

“…Perfluorocarbons, however, do not appear to be tolerated well when left in the eye for extended periods of time [13,14,15,16,17]. Similarly, it is not clear whether fluorosilicones and semifluorinated alkanes are better tolerated, and both have been shown to incite an inflammatory response in the eye [18,19,20,21].…”

New substances for intraocular tamponades: perfluorocarbon liquids, hydrofluorocarbon liquids and hydrofluorocarbon-oligomers in vitreoretinal surgery

“…However, at present complete removal of the substance at the end of surgery is recommended because intraocular long-term tolerance is unsatisfactory as demonstrated in animal experiments or described in clinical reports after use in humans [7,12,13,14,16,22,32,35,41,46]. Intraocular droplet formation does occur within the first few days, demonstrated here in a rabbit eye 5 days after injection.…”