Anthelmintic resistance in India

Gill, B. S.

doi:10.1016/0304-4017(95)00884-5

Cited by 38 publications

(25 citation statements)

References 5 publications

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“…Reduced efficacies of the fenbendazole and levamisole drugs against GI nematode parasites in goats have been documented earlier by several workers (Yadav and Uppal 1992;Singh et al 2002;Waruiru et al 2003;Ram et al 2007). Ivermectin showed 98.11% potency against the GI nematode parasites in goats which is in line with earlier reports (Gill 1996;Ram et al 2007). The between group differences in ivermectin (Gr-C) treated animals were significant (p \ 0.05) in comparison with fenbendazole (Gr-A), levamisole (Gr-B) and untreated controls (Gr-D).…”

Section: Resultssupporting

confidence: 90%

Efficacy of fenbendazole, levamisole and ivermectin against gastrointestinal nematodes in Jamunapari goats

Godara¹,

Sharma²,

Sodhi³

2011

J Parasit Dis

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Efficacy of fenbendazole, levamisole and ivermectin was checked in comparison to untreated controls in twenty Jamunapari goats, naturally infected with gastrointestinal nematode parasites. Faecal examination at day 0 revealed an egg per gram of 930 ± 175.1, 1350 ± 421.1, 1060 ± 224.9 and 800 ± 279.7 in group A, B, C and D, respectively having five animals each. The results of larval culture examination revealed the presence of Haemonchus, Trichostrongylus, Oesophagostomum, Bunostomum and Strongyloides spp. in these animals. Faecal egg counts of the animals treated with fenbendazole (group A), levamisole (group B) and ivermectin (group C) were reduced by 23.66, 63.70 and 98.11%, respectively on day 14 post-treatment.

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Section: Resultssupporting

confidence: 90%

Efficacy of fenbendazole, levamisole and ivermectin against gastrointestinal nematodes in Jamunapari goats

Godara¹,

Sharma²,

Sodhi³

2011

J Parasit Dis

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“…The trend continued with the introduction of a new generation of drugs in the same class as well as other classes like imidathiazole and macrocyclic lactones. This has led to the development of multiple drug resistant (MDR) strains of H. contortus in many parts of the world viz., South America (Nari et al 1996), South Africa (van Wyk et al 1999, Malaysia (Chandrawathani et al 2003), Southeast USA (Mortensen et al 2003), Australia (Besier and Love 2003), New Zealand (Leathwick et al 2001) and India (Gill 1996;Swarnkar et al 1999;Easwaran et al 2009). In Tiwari et al (2006) reported the prevalence rate of BZ resistance in H. contortus of Indian isolates by RFLP-PCR technique.…”

Section: Discussionmentioning

confidence: 99%

Genotyping of benzimidazole resistant and susceptible isolates of Haemonchus contortus from sheep by allele specific PCR

et al. 2016

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Extensive and indiscriminate use of the benzimidazole class of drugs has led to the onset of anthelmintic resistance. In tropical countries like India, Haemonchus contortus is the most pathogenic parasite infecting sheep and goats. The widespread presence of resistant helminths (especially H. contortus) threatens the livestock farming. The use of various drugs has led to single nucleotide polymorphism that causes specific amino acid substitutions in b-tubulin protein of H. contortus to confer resistance. This emphasizes the need for a survey on the present status of resistance in India. In this study, allele specific PCR was employed to screen the presence of a SNP, a thymine-toadenine transversion which leads to substitution of amino acid in codon 200 of b-tubulin gene that is correlated specifically with BZ resistance. Third stage larvae (L3) from pooled faecal cultures of four organized sheep farms served as a source of genomic DNA for identification of H. contortus and further genotype analysis. A total of 1000 larvae was screened, out of which 673 larvae were identified as H. contortus. Among 673 H. contortus larvae, 539 larvae (80 %) were genotyped as homozygous resistant (rr) and remaining 134 (20 %) were heterozygous susceptible (Sr) by allele specific PCR. The concluded resistance status reasons out the failure of anthelmintic drug in treating ruminants. Immediate steps are needed to avoid further aggravation of the problem. Target selective treatment by reviewing the resistance status of individual drugs, appropriate use of anthelmintic drugs and other control strategies will provide a pragmatic option for delaying the further spread of anthelmintic resistance.

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“…Esse fato fortalece a proposta de Fernandes et al (2004), que o pastejo rotacionado e consorciado com bovinos é eficaz na redução da infecção parasitária em ovinos. A resistência dos helmintos em relação ao Albendazol também foi registrada por Gill (1996), Soccol et al (1996) e Molento (2004). Com relação à molécula Ivermectina, não diferem do descrito por Soccol et al (1996), Molento (2004) e Rosalinski-Moraes et al (2007).…”

Section: Discussionunclassified

“…E inferiores aos relatados por Gill (1996), Farias et al (1997) e Traversa et al (2007, onde a resistência foi relatada, respectivamente, em 100%; 95,7% e 100% dos rebanhos.…”

Section: Quadro 4 Percentuais Da Condição De Resistência (R) Baixa unclassified

Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul

Sczesny-Moraes

Bianchin²,

Silva³

et al. 2010

Pesq. Vet. Bras.

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ABSTRACT.-Sczesny-Moraes E.A., Bianchin I., Silva K.F., Catto J. Among the methods of control of gastrointestinal worms in sheep, the use of chemicals is the most common. However, the continued, and indiscriminate, use of these products has selected populations of resistant helminths to anthelmintics, a phenomenon reported in the whole world. This study aimed to identify the species of gastrointestinal parasites and diagnose the status of anthelmintic resistance in sheep in the State of Mato Grosso do Sul Brazil. Feacal egg count reduction tests (FECRT) were performed in flocks of sixteen farms, and the seven formulations used contained the following pharmacological bases: Albendazole, Ivermectin, Levamizol, Trichlorfon, Moxidectin, Closantel and one containing the first three in association. The species identified at necropsy, in adult sheep, were: Haemonchus contortus, Trichostrongylus colubriformis, Cooperia curticei, C. punctata, C. pectinata and Oesophagostomum columbianum, in order of prevalence. The formulations containing Albendazole and Ivermectin did not show efficacy in reducing the EPG in the flocks tested, with average reductions of 0.7 and -19.6%, respectively. Closantel presented an average efficacy of 6.7%; Levamisolee, Moxidectin and Trichlorfon, 28.7, 26.8 and 65% respectively, the combination of three bases (Albendazole, Ivermectin and Levamizol), an average efficacy of 55.8 %. The average percentages of infective larvae recovered in the faecal cultures, pre and post treatment were similar, indicating that resistance to the bases tested is present in all species cited, to a greater or lesser degree. The two genera predominantly resistant are Haemonchus sp., with 86.9%, followed by Trichostrongylus sp., with an average of 47.5%, Strongyloides sp. 33.6%, Oesophagostomum sp.

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Anthelmintic resistance in India

Cited by 38 publications

References 5 publications

Efficacy of fenbendazole, levamisole and ivermectin against gastrointestinal nematodes in Jamunapari goats

Efficacy of fenbendazole, levamisole and ivermectin against gastrointestinal nematodes in Jamunapari goats

Genotyping of benzimidazole resistant and susceptible isolates of Haemonchus contortus from sheep by allele specific PCR

Resistência anti-helmíntica de nematóides gastrintestinais em ovinos, Mato Grosso do Sul

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