Anthelmintic β-hydroxyketoamides (BKAs)

Lee, Byung H.; Clothier, Michael F.; Dutton, Fred E.; Conder, George A.; Johnson, Sandra S.

doi:10.1016/s0960-894x(98)00588-5

Cited by 67 publications

(42 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The structural type of coumarin enables its derivatives to interact readily with all kinds of enzymes and receptors in organisms through weak bond interactions. So they exhibit wide potentiality as medicinal drugs 23 with various biological and pharmacological activities such as antibacterial, antifungal 24 , antioxidant 25 , anti-inflammatory 26 , analgesic 27 , anticancer 28 , anthelmintic 29 , anti-HIV 30 and antiviral 31 activities. In recent studies, the coumarin heterocycles (Figure 2), as antimicrobial agents, have attracted extensive interest.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of novel 3-substituted amino-4-hydroxylcoumarin derivatives as chitin synthase inhibitors and antifungal agents

Chen

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

A series of novel 3-substituted amino-4-hydroxycoumarin derivatives have been designed and synthesized as chitin synthase (CHS) inhibitors. All the synthesized compounds have been screened for their CHS inhibition activity and antimicrobial activity in vitro. The enzymatic assay indicated that most of the compounds have good inhibitory activity against CHS, in which compound 6o with IC 50 of 0.10 mmol/L had stronger activity than that of polyoxins B, which acts as control drug with IC 50 of 0.18 mmol/L. As far as the antifungal activity is concerned, most of the compounds possessed moderate to excellent activity against some representative pathogenic fungi. Especially, compound 6b was found to be the most potent agent against Cryptococcus neoformans with minimal inhibitory concentration (MIC) of 4 lg/mL. Moreover, the results of antibacterial screening showed that these compounds have negligible actions to some tested bacteria. Therefore, these compounds would be promising to develop selective antifungal agents.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of novel 3-substituted amino-4-hydroxylcoumarin derivatives as chitin synthase inhibitors and antifungal agents

Chen

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

“…Heterocycles containing this important structural motif exhibit a wide range of pharmaceutical activities that include antibacterial, anti-HIV, antiviral, anticoagulant, antioxidant and anticancer activities [116][117][118][119][120]. Goswami [121] synthesized a wide range of 4-substituted coumarins (60) by the reaction of a wide range of structurally diverse phenols (59) and ethyl acetoacetate (17) or ethyl benzoyl acetate (17c) in the presence of nanocrystalline ZnO as catalyst and pyridine dicarboxylic acid as co-catalyst in acetonitrile under reflux conditions (Table 17).…”

Section: Synthesis Of Coumarinsmentioning

confidence: 99%

Recent developments on nano-ZnO catalyzed synthesis of bioactive heterocycles

Banerjee

2017

J Nanostruct Chem

View full text Add to dashboard Cite

Last decade has seen tremendous applications of nano-ZnO as a mild, cheap, efficient, commercially available, environmentally benign, non-toxic, reusable, heterogeneous catalyst for the various organic transformations. The present review summarizes the applications of nano-ZnO as an efficient heterogeneous catalyst for the synthesis of diverse biologically relevant heterocycles reported so far. Graphical abstract Nano

show abstract

“…Up to date, many synthetic methods have been developed for the construction of pyrroles, including the classical Knorr reaction, the Hantzsch reaction [4], Buchwald-Hartwig coupling [5] and the Paal-Knorr condensation reaction. Additionally, other new methodologies, such as transition-metal catalyzed cyclizations [6], cyclo-addition reactions [7] and MCRs were developed for preparing new pyrrole derivatives. However; some of these methods have significant limits such as boring workup procedures, harsh reaction conditions, low yields, long reaction times or the condition for an inert atmosphere.…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient and Eco-Friendly One-Pot Synthesis of Penta Substitute Pyrrole Derivatives under Catalyst-Free Conditions

Viradiya

Baria

Kakadiya

et al. 2014

ILCPA

View full text Add to dashboard Cite

An eco-friendly and efficient one-pot synthesis of penta-substituted pyrrole derivatives via a four-component reaction of maldrum's acid, arylglyoxal monohydrate, dimethyl but-2-yne-dioate and amines under catalyst-free conditions in an environmentally friendly medium is described. The simple experimental procedure, catalyst-free reaction conditions, short period of conversion, and excellent yields are the advantages of the present method. Good chemical yields have been achieved without the need for chromatography and recrystallization or other purification methods.

show abstract

Anthelmintic β-hydroxyketoamides (BKAs)

Cited by 67 publications

References 12 publications

Synthesis and biological evaluation of novel 3-substituted amino-4-hydroxylcoumarin derivatives as chitin synthase inhibitors and antifungal agents

Synthesis and biological evaluation of novel 3-substituted amino-4-hydroxylcoumarin derivatives as chitin synthase inhibitors and antifungal agents

Recent developments on nano-ZnO catalyzed synthesis of bioactive heterocycles

Highly Efficient and Eco-Friendly One-Pot Synthesis of Penta Substitute Pyrrole Derivatives under Catalyst-Free Conditions

Contact Info

Product

Resources

About